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Chemical Compound Review

Diocaine     2-diethylaminoethyl 3-amino-4-propoxy...

Synonyms: Alcaine, Kainair, Ophthaine, Ophthetic, Paracaine, ...
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Disease relevance of C07383


High impact information on C07383


Chemical compound and disease context of C07383


Biological context of C07383


Anatomical context of C07383

  • Topically applied eledoisin did not pharmacologically stimulate lacrimal secretion but rather increased lacrimal gland secretion only in non-anesthetized eyes through a sensory reflex mechanism that is blocked by proparacaine [15].
  • All coadministered drugs except proparacaine reduced intraocular timolol concentrations by varying extents depending on the sampling time, while increasing the timolol concentrations in the conjunctiva and sclera [16].
  • Does 0.5% proparacaine result in an alteration in corneal thickness due to changes in the corneal epithelium [17]?
  • We postulate that one mechanism by which proparacaine inhibits corneal epithelial migration and adhesion is through alteration of the actin cytoskeleton [18].
  • The local anesthetic proparacaine modifies sodium transport in toad skin and perturbs the structures of model and cell membranes [14].

Associations of C07383 with other chemical compounds


Gene context of C07383

  • Instillation of one drop of 0.5% proparacaine caused a significant, but gradual, increase in epithelial cell sloughing rate over a period of hours, as indicated by subsequent BTS irrigations of the cornea [22].

Analytical, diagnostic and therapeutic context of C07383


  1. Dilute topical proparacaine for pain relief after photorefractive keratectomy. Shahinian, L., Jain, S., Jager, R.D., Lin, D.T., Sanislo, S.S., Miller, J.F. Ophthalmology (1997) [Pubmed]
  2. Relief of trigeminal neuralgia by proparacaine. Vassilouthis, J. J. Neurol. Neurosurg. Psychiatr. (1994) [Pubmed]
  3. Allergic contact fingertip dermatitis secondary to proxymetacaine in an ophthalmologist. Riddell, C.E., Reed, J., Shaw, S., Duvall-Young, J. Eye (London, England) (2000) [Pubmed]
  4. The effect of corneal hypesthesia on the duration of proparacaine anesthetic eyedrops. Weiss, J.S., Goren, M.B. Am. J. Ophthalmol. (1991) [Pubmed]
  5. The survival of herpes simplex virus in multidose office ophthalmic solutions. Romanowski, E.G., Barnhorst, D.A., Kowalski, R.P., Gordon, Y.J. Am. J. Ophthalmol. (1999) [Pubmed]
  6. Factors affecting therapeutic concentration of topical aminocaproic acid in traumatic hyphema. Ehlers, W.H., Crouch, E.R., Williams, P.B., Riggs, P.K. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  7. Corneal endothelial toxicity of topical anesthesia. Judge, A.J., Najafi, K., Lee, D.A., Miller, K.M. Ophthalmology (1997) [Pubmed]
  8. Flap suturing with proparacaine for recurrent epithelial ingrowth following laser in situ keratomileusis surgery. Spanggord, H.M., Epstein, R.J., Lane, H.A., Candal, E.M., Klein, S.R., Majmudar, P.A., Dennis, R.F. Journal of cataract and refractive surgery. (2005) [Pubmed]
  9. Comparative toxicity of tetracaine, proparacaine and cocaine evaluated with primary cultures of rabbit corneal epithelial cells. Grant, R.L., Acosta, D. Exp. Eye Res. (1994) [Pubmed]
  10. Inhibition of pilocarpine-induced aqueous humor flare, hypotony, and miosis by topical administration of anti-inflammatory and anesthetic drugs to dogs. Krohne, S.G., Gionfriddo, J., Morrison, E.A. Am. J. Vet. Res. (1998) [Pubmed]
  11. Visual acuity after topical application of proparacaine. Bossart, P.J., Stephen, R.L., Herr, R.D., Berndt, D. Annals of emergency medicine. (1997) [Pubmed]
  12. Toxicity of topical anesthetic agents to human keratocytes in vivo. Moreira, L.B., Kasetsuwan, N., Sanchez, D., Shah, S.S., LaBree, L., McDonnell, P.J. Journal of cataract and refractive surgery. (1999) [Pubmed]
  13. A fatal case involving proparacaine. Reed, D., Cravey, R.H. J. Forensic Sci. (1976) [Pubmed]
  14. The local anesthetic proparacaine modifies sodium transport in toad skin and perturbs the structures of model and cell membranes. Suwalsky, M., Schneider, C., Norris, B., Villena, F., Cárdenas, H., Cuevas, F., Sotomayor, C.P. Z. Naturforsch., C, J. Biosci. (2002) [Pubmed]
  15. Eledoisin and lacrimal secretion in the rabbit. Rossi, S.R., Dartt, D.A., Gilbard, J.P. Curr. Eye Res. (1990) [Pubmed]
  16. Ocular drug interactions involving topically applied timolol in the pigmented rabbit. Luo, A.M., Sasaki, H., Lee, V.H. Curr. Eye Res. (1991) [Pubmed]
  17. Short-term effects of proparacaine on human corneal thickness. Herse, P., Siu, A. Acta ophthalmologica. (1992) [Pubmed]
  18. Effects of proparacaine on actin cytoskeleton of corneal epithelium. Dass, B.A., Soong, H.K., Lee, B. Journal of ocular pharmacology. (1988) [Pubmed]
  19. Topical anesthesia: Proxymetacaine versus Amethocaine for clear corneal phacoemulsification. Hamilton, R., Claoué, C. Journal of cataract and refractive surgery. (1998) [Pubmed]
  20. A comparison of Fluoracaine and Fluorox on corneal epithelial cell desquamation after Goldmann Applanation Tonometry. Yeung, K.K., Kageyama, J.Y., Carnevali, T. Optometry (St. Louis, Mo.) (2000) [Pubmed]
  21. The effects of topical and general anesthesia on ocular drug levels and intraocular pressure lowering activity of topically applied carbonic anhydrase inhibitors. Bar-Ilan, A., Pessah, N.I. Journal of ocular pharmacology. (1988) [Pubmed]
  22. Investigation of sloughed corneal epithelial cells collected by non-invasive irrigation of the corneal surface. Fullard, R.J., Wilson, G.S. Curr. Eye Res. (1986) [Pubmed]
  23. Topical proparacaine and suture removal after blepharoplasty. Glatt, H.J., Putterman, A.M., Farber, M.D. Arch. Ophthalmol. (1990) [Pubmed]
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