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Disease relevance of Thrombelastography


High impact information on Thrombelastography

  • Comparative in vitro efficacy of different platelet glycoprotein IIb/IIIa antagonists on platelet-mediated clot strength induced by tissue factor with use of thromboelastography: differentiation among glycoprotein IIb/IIIa antagonists [5].
  • In the present study, the in vitro efficacy of different platelet glycoprotein IIb/IIIa (GPIIb/IIIa) antagonists on platelet-fibrin-mediated clot strength under shear was compared with the antiaggregatory efficacy by using tissue factor (TF) thromboelastography (TEG) [5].
  • Thrombelastography for the monitoring of lipopolysaccharide induced activation of coagulation [6].
  • In vitro comparison of the effect of fondaparinux and enoxaparin on whole blood tissue factor-triggered thromboelastography profile [7].
  • RESULTS: Thrombelastography revealed a hypercoagulable state in non-cirrhotic patients with PBC/PSC, but not in those with HCV (ma-value: 6.54[6.25-6.92, 95%CI] vs. 5.39[5.11-5.58], P < 0.05) possibly due to higher fibrinogen levels in PBC/PSC patients (369[329-418]mg/dl vs. 263[250-275]mg/dl, P < 0.05) [8].

Chemical compound and disease context of Thrombelastography


Biological context of Thrombelastography


Anatomical context of Thrombelastography

  • Thirty-eight patients (29 undergoing coronary artery bypass grafting and 9 undergoing valve replacement) were studied with activated clotting time, thromboelastography, and coagulation profiles during three periods: before bypass, during bypass, and after protamine administration [15].

Associations of Thrombelastography with chemical compounds


Gene context of Thrombelastography

  • We determined that peroxynitrite decreased tPA activity via thrombelastography [20].
  • Thrombelastography was used to quantitatively compare the clot-lysing efficiency of 6 different plasminogen activators, using human whole blood, pooled normal plasma, and platelet rich plasma [21].
  • Because thromboelastography has proven useful in this regard, we evaluated the use of celite or tissue factor (TF) activation and heparinase modification of blood samples to allow rapid determination of thromboelastogram data in children younger than 2 yr undergoing CPB [22].
  • Thrombelastography (TEG) and Sonoclot analysis (SCT) are measures of viscoelastic properties of blood which allow rapid intraoperative evaluation of coagulation factor and platelet activity as well as overall clot integrity from a single blood sample [23].
  • Viscoelastic analysis of anticoagulation reversal was performed by adding protamine or PF4 at reversal ratios of 1.3:1 protamine:heparin, and 3.2:1 PF4:heparin using thromboelastography (n = 12) [24].

Analytical, diagnostic and therapeutic context of Thrombelastography


  1. Comparison of coagulation and blood loss during anaesthesia with inhaled isoflurane or intravenous propofol. Law, N.L., Ng, K.F., Irwin, M.G., Man, J.S. British journal of anaesthesia. (2001) [Pubmed]
  2. Hemostatic analysis of a patient undergoing off-pump coronary artery bypass surgery with argatroban anticoagulation. Kieta, D.R., McCammon, A.T., Holman, W.L., Nielsen, V.G. Anesth. Analg. (2003) [Pubmed]
  3. Assessment of blood coagulation in severe liver disease using thromboelastography: use of citrate storage versus native blood. Mancuso, A., Fung, K., Cox, D., Mela, M., Patch, D., Burroughs, A.K. Blood Coagul. Fibrinolysis (2003) [Pubmed]
  4. The effect of low-dose heparin on hypercoagulability following abdominal aortic surgery. Gibbs, N.M., Bell, R. Anaesthesia and intensive care. (1998) [Pubmed]
  5. Comparative in vitro efficacy of different platelet glycoprotein IIb/IIIa antagonists on platelet-mediated clot strength induced by tissue factor with use of thromboelastography: differentiation among glycoprotein IIb/IIIa antagonists. Mousa, S.A., Khurana, S., Forsythe, M.S. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  6. Thrombelastography for the monitoring of lipopolysaccharide induced activation of coagulation. Zacharowski, K., Sucker, C., Zacharowski, P., Hartmann, M. Thromb. Haemost. (2006) [Pubmed]
  7. In vitro comparison of the effect of fondaparinux and enoxaparin on whole blood tissue factor-triggered thromboelastography profile. Gerotziafas, G.T., Chakroun, T., Samama, M.M., Elalamy, I. Thromb. Haemost. (2004) [Pubmed]
  8. Platelet function rather than plasmatic coagulation explains hypercoagulable state in cholestatic liver disease. Pihusch, R., Rank, A., Göhring, P., Pihusch, M., Hiller, E., Beuers, U. J. Hepatol. (2002) [Pubmed]
  9. Anaphylaxis with associated fibrinolysis, reversed with tranexamic acid and demonstrated by thrombelastography. De Souza, R.L., Short, T., Warman, G.R., Maclennan, N., Young, Y. Anaesthesia and intensive care. (2004) [Pubmed]
  10. Epsilon-aminocaproic acid for treatment of fibrinolysis during liver transplantation. Kang, Y., Lewis, J.H., Navalgund, A., Russell, M.W., Bontempo, F.A., Niren, L.S., Starzl, T.E. Anesthesiology (1987) [Pubmed]
  11. The detection of changes in heparin activity in the rabbit: a comparison of anti-xa activity, thrombelastography, activated partial thromboplastin time, and activated coagulation time. Nielsen, V.G. Anesth. Analg. (2002) [Pubmed]
  12. The effect of potato starch derived and corn starch derived hydroxyethyl starch on in vitro blood coagulation. Jamnicki, M., Zollinger, A., Seifert, B., Popovic, D., Pasch, T., Spahn, D.R. Anaesthesia. (1998) [Pubmed]
  13. The effects of ropivacaine hydrochloride on coagulation and fibrinolysis. An assessment using thromboelastography. Porter, J.M., McGinley, J., O'Hare, B., Shorten, G.D. Anaesthesia. (1999) [Pubmed]
  14. Perioperative monitoring of primary and secondary hemostasis in coronary artery bypass grafting. Hertfelder, H.J., Bös, M., Weber, D., Winkler, K., Hanfland, P., Preusse, C.J. Semin. Thromb. Hemost. (2005) [Pubmed]
  15. Thromboelastography as an indicator of post-cardiopulmonary bypass coagulopathies. Spiess, B.D., Tuman, K.J., McCarthy, R.J., DeLaria, G.A., Schillo, R., Ivankovich, A.D. Journal of clinical monitoring. (1987) [Pubmed]
  16. Bacterial infection in cirrhosis impairs coagulation by a heparin effect: a prospective study. Montalto, P., Vlachogiannakos, J., Cox, D.J., Pastacaldi, S., Patch, D., Burroughs, A.K. J. Hepatol. (2002) [Pubmed]
  17. In vitro evaluation of the effect of profound haemodilution with hydroxyethyl starch 6%, modified fluid gelatin 4% and dextran 40 10% on coagulation profile measured by thromboelastography. Mortier, E., Ongenae, M., De Baerdemaeker, L., Herregods, L., Den Blauwen, N., Van Aken, J., Rolly, G. Anaesthesia. (1997) [Pubmed]
  18. In vitro effects of local anaesthetics on the thromboelastographic profile of parturients. Siau, C., Ng, H.P., Tan, G.M., Ho, B.S., Pua, H.L. British journal of anaesthesia. (2005) [Pubmed]
  19. Low-dose oral contraceptive effects on thromboelastogram criteria and relationship to hypercoagulability. Zahn, C.M., Gonzalez, D.I., Suto, C., Kennedy, S., Hines, J.F. Am. J. Obstet. Gynecol. (2003) [Pubmed]
  20. Peroxynitrite inactivates tissue plasminogen activator. Nielsen, V.G., Crow, J.P., Zhou, F., Parks, D.A. Anesth. Analg. (2004) [Pubmed]
  21. In vitro comparison of fibrinolytic activity of plasminogen activators using a thrombelastographic method: in vivo evaluation of the B-chain-streptokinase complex in the dog model using pre-titered doses. Summaria, L., Sandesara, J., Yang, G., Vagher, J.P., Caprini, J.A. Thromb. Haemost. (1986) [Pubmed]
  22. Rapid evaluation of coagulopathies after cardiopulmonary bypass in children using modified thromboelastography. Miller, B.E., Guzzetta, N.A., Tosone, S.R., Levy, J.H. Anesth. Analg. (2000) [Pubmed]
  23. Comparison of viscoelastic measures of coagulation after cardiopulmonary bypass. Tuman, K.J., Spiess, B.D., McCarthy, R.J., Ivankovich, A.D. Anesth. Analg. (1989) [Pubmed]
  24. Heparin neutralization by recombinant platelet factor 4 and protamine. Levy, J.H., Cormack, J.G., Morales, A. Anesth. Analg. (1995) [Pubmed]
  25. Endogenous heparin-like substances significantly impair coagulation in patients undergoing orthotopic liver transplantation. Kettner, S.C., Gonano, C., Seebach, F., Sitzwohl, C., Acimovic, S., Stark, J., Schellongowski, A., Blaicher, A., Felfernig, M., Zimpfer, M. Anesth. Analg. (1998) [Pubmed]
  26. Thromboxane B2 blood levels and incipient system clotting in heparin free hemodialysis. Keller, F., Hericks, K., Schuller, I., Passfall, J., Joerres, A., Meinhold, H. ASAIO journal (American Society for Artificial Internal Organs : 1992) (1995) [Pubmed]
  27. Intraoperative anticoagulation during arterial reconstructive procedures. Lee, B.Y., Thoden, W.R., Mc Cann, W.J., Madden, J.L., Del Guercio, L.R., Berkowitz, P. Surgery, gynecology & obstetrics. (1982) [Pubmed]
  28. Blood coagulation abnormalities in the Schönlein-Henoch syndrome in adults. Boros, G., Gofman, L., Sámsik, J., Nagy, J., Hámori, A., Deák, G. Acta medica Academiae Scientiarum Hungaricae. (1979) [Pubmed]
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