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Chemical Compound Review

Capramol     6-aminohexanoic acid

Synonyms: Caprocid, Caproamin, Epsamon, Capralense, Epsikapron, ...
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Disease relevance of Capralense


High impact information on Capralense


Chemical compound and disease context of Capralense


Biological context of Capralense


Anatomical context of Capralense

  • To analyze the possible involvement of JH in the central integration of the female-produced sex pheromone, we investigated the pheromone response of olfactory antennal lobe (AL) interneurons in male A. ipsilon as a function of age and JH status by using intracellular recordings [19].
  • The antibody content of mouse serum was assessed by (a) its ability to inhibit rosetting of 2,4,6-trinitro-phenyl-sheep red blood cells around MOPC 315 myeloma cells, and (b) by a solid phase antigen-binding plate assay based on reactivity with 125I-Protein A and inhibition in the presence of dinitrophenyl aminocaproic acid [20].
  • 6-Aminohexanoic acid similarly enhanced HMBA-induced differentiation of HL60 cells [21].
  • Ascitic fluid of tum or-bearing animals reacted specifically with MOPC 315 IgA and the reaction was inhibited by DNP- aminocaproic acid, indicating that the monoclonal antibody was directed against the hapten-binding site of MOPC 315 IgA [22].
  • Fusion apo(a) KIV37 was isolated from the inclusion bodies and purified by lysine-Sepharose affinity chromatography by eluting with 0.2 M epsilon-aminocaproic acid [23].

Associations of Capralense with other chemical compounds


Gene context of Capralense

  • Furthermore, the degradation of t-PA was not influenced by 10 mM 6-aminohexanoic acid, a lysine analogue [29].
  • The relevance of the modifications of the fibrinolytic balance of mouse microvascular endothelium in bFGF-induced angiogenesis was validated in vivo by a gelatin-sponge assay in which the plasmin inhibitors tranexamic acid and epsilon-aminocaproic acid given to mice in the drinking water inhibited neovascularization induced by the growth factor [30].
  • This increase in invasion could in turn be abolished by antibodies directed to uPA and uPAR and by the plasmin inhibitors epsilon-aminocaproic acid and aprotinin [31].
  • Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent [32].
  • Laminin degradation by Co115 cells was completely inhibited by 100 micrograms/ml of polyclonal anti-t-PA IgG, by the plasmin inhibitors aprotinin (100 micrograms/ml) or epsilon-aminocaproic acid (EACA; at 0.3 M), but not by antibodies against u-PA or u-PAR nor by nonimmune IgG [33].

Analytical, diagnostic and therapeutic context of Capralense


  1. Treatment of bleeding in hereditary hemorrhagic telangiectasia with aminocaproic acid. Korzenik, J.R., Topazian, M.D., White, R. N. Engl. J. Med. (1994) [Pubmed]
  2. Epsilon aminocaproic acid for hereditary angioedema. Frank, M., Gelfand, J.A., Alling, D.W., Sherins, R.J. N. Engl. J. Med. (1977) [Pubmed]
  3. Evolutionary adaptation of plasmid-encoded enzymes for degrading nylon oligomers. Okada, H., Negoro, S., Kimura, H., Nakamura, S. Nature (1983) [Pubmed]
  4. Aminocaproic acid. Use in control of hemorrhage in patients with amegakaryocytic thrombocytopenia. Gardner, F.H., Helmer, R.E. JAMA (1980) [Pubmed]
  5. Myoglobinuria following aminocaproic acid administration. Rizza, R.A., Sclonick, S., Conley, C.L. JAMA (1976) [Pubmed]
  6. The influence of the nature of the asparagine 289-linked oligosaccharide on the activation by urokinase and lysine binding properties of natural and recombinant human plasminogens. Davidson, D.J., Castellino, F.J. J. Clin. Invest. (1993) [Pubmed]
  7. Transforming growth factor beta regulation of migration in wounded rat intestinal epithelial monolayers. Ciacci, C., Lind, S.E., Podolsky, D.K. Gastroenterology (1993) [Pubmed]
  8. Epsilon-aminocaproic acid in the treatment of patients with acute promyelocytic leukemia and acquired alpha-2-plasmin inhibitor deficiency. Schwartz, B.S., Williams, E.C., Conlan, M.G., Mosher, D.F. Ann. Intern. Med. (1986) [Pubmed]
  9. Novel degradation pathway of glycated amino acids into free fructosamine by a Pseudomonas sp. soil strain extract. Gerhardinger, C., Marion, M.S., Rovner, A., Glomb, M., Monnier, V.M. J. Biol. Chem. (1995) [Pubmed]
  10. Intracranial aneurysms and subarachnoid hemorrhage. A cooperative study. Antifibrinolytic therapy in recent onset subarachnoid hemorrhage. Nibbelink, D.W., Torner, J.C., Henderson, W.G. Stroke (1975) [Pubmed]
  11. Combination of aminocaproic acid and nicardipine in treatment of aneurysmal subarachnoid hemorrhage. Beck, D.W., Adams, H.P., Flamm, E.S., Godersky, J.C., Loftus, C.M. Stroke (1988) [Pubmed]
  12. Early thrombus formation on heparin-bonded pulmonary artery catheters in patients receiving epsilon aminocaproic acid. Dentz, M.E., Slaughter, T.F., Mark, J.B. Anesthesiology (1995) [Pubmed]
  13. Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli. Tilley, L.D., Mellbye, B.L., Puckett, S.E., Iversen, P.L., Geller, B.L. J. Antimicrob. Chemother. (2007) [Pubmed]
  14. Is epsilon-aminocaproic acid as effective as aprotinin in reducing bleeding with cardiac surgery?: a meta-analysis. Munoz, J.J., Birkmeyer, N.J., Birkmeyer, J.D., O'Connor, G.T., Dacey, L.J. Circulation (1999) [Pubmed]
  15. Plasminogen interactions with platelets in plasma. Adelman, B., Rizk, A., Hanners, E. Blood (1988) [Pubmed]
  16. Characterization of plasminogen as an adhesive ligand for integrins alphaMbeta2 (Mac-1) and alpha5beta1 (VLA-5). Lishko, V.K., Novokhatny, V.V., Yakubenko, V.P., Skomorovska-Prokvolit, H.V., Ugarova, T.P. Blood (2004) [Pubmed]
  17. Proton magnetic resonance study of kringle 1 from human plasminogen. Insights into the domain structure. Motta, A., Laursen, R.A., Rajan, N., Llinás, M. J. Biol. Chem. (1986) [Pubmed]
  18. A novel method of activation of cross-linked agaroses with 1,1'-carbonyldiimidazole which gives a matrix for affinity chromatography devoid of additional charged groups. Bethell, G.S., Ayers, J.S., Hancock, W.S., Hearn, M.T. J. Biol. Chem. (1979) [Pubmed]
  19. Effect of juvenile hormone on the central nervous processing of sex pheromone in an insect. Anton, S., Gadenne, C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  20. Induction of cytotoxic factors by immunization of mice with Freund's adjuvant components. Baumal, R., Marks, A., Mahony, J., Bose, A. Cancer Res. (1980) [Pubmed]
  21. Induction of differentiation of human promyelocytic leukemia cells (HL60) by metabolites of hexamethylene bisacetamide. Snyder, S.W., Egorin, M.J., Geelhaar, L.A., Hamburger, A.W., Callery, P.S. Cancer Res. (1988) [Pubmed]
  22. A monoclonal antiidiotypic antibody to MOPC 315 IgA inhibits the growth of MOPC 315 myeloma cells in vitro. Mahony, J., Bose, A., Cowdrey, D., Nusair, T., Lei, M., Harris, J., Marks, A., Baumal, R. J. Immunol. (1981) [Pubmed]
  23. Cloning, expression, and characterization of human apolipoprotein(a) kringle IV37. LoGrasso, P.V., Cornell-Kennon, S., Boettcher, B.R. J. Biol. Chem. (1994) [Pubmed]
  24. Plasmin-mediated fibrinolysis by variant recombinant tissue plasminogen activators. Urano, S., Metzger, A.R., Castellino, F.J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  25. Metabolism of hexamethylene bisacetamide and its metabolites in leukemic cells. Egorin, M.J., Snyder, S.W., Cohen, A.S., Zuhowski, E.G., Subramanyam, B., Callery, P.S. Cancer Res. (1988) [Pubmed]
  26. Thrombospondin forms complexes with single-chain and two-chain forms of urokinase. Silverstein, R.L., Nachman, R.L., Pannell, R., Gurewich, V., Harpel, P.C. J. Biol. Chem. (1990) [Pubmed]
  27. Isolation of a human plasmin-derived, functionally active, light (B) chain capable of forming with streptokinase an equimolar light (B) chain-streptokinase complex with plasminogen activator activity. Summaria, L., Robbins, K.C. J. Biol. Chem. (1976) [Pubmed]
  28. S epsilon S mu and S epsilon S gamma switch circles in human nasal mucosa following ex vivo allergen challenge: evidence for direct as well as sequential class switch recombination. Cameron, L., Gounni, A.S., Frenkiel, S., Lavigne, F., Vercelli, D., Hamid, Q. J. Immunol. (2003) [Pubmed]
  29. Demonstration of a specific clearance receptor for tissue-type plasminogen activator on rat Novikoff hepatoma cells. Nguyen, G., Self, S.J., Camani, C., Kruithof, E.K. J. Biol. Chem. (1992) [Pubmed]
  30. Basic fibroblast growth factor-induced angiogenic phenotype in mouse endothelium. A study of aortic and microvascular endothelial cell lines. Bastaki, M., Nelli, E.E., Dell'Era, P., Rusnati, M., Molinari-Tosatti, M.P., Parolini, S., Auerbach, R., Ruco, L.P., Possati, L., Presta, M. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  31. Regulation of urokinase plasminogen activator/plasmin-mediated invasion of melanoma cells by the integrin vitronectin receptor alphaVbeta3. Khatib, A.M., Nip, J., Fallavollita, L., Lehmann, M., Jensen, G., Brodt, P. Int. J. Cancer (2001) [Pubmed]
  32. Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent. Doyle, M.E., Greig, N.H., Holloway, H.W., Betkey, J.A., Bernier, M., Egan, J.M. Endocrinology (2001) [Pubmed]
  33. Human Co115 colon carcinoma cells potentiate the degradation of laminin mediated by tissue-type plasminogen activator. Tran-Thang, C., Vouillamoz, D., Kruithof, E.K., Sordat, B. J. Cell. Physiol. (1994) [Pubmed]
  34. Prevention of early recurrence of spontaneous subarachnoid haemorrhage by epsilon-aminocaproic acid. Chowdhary, U.M., Carey, P.C., Hussein, M.M. Lancet (1979) [Pubmed]
  35. Mini-plasminogen: a mechanism for leukocyte modulation of plasminogen activation by urokinase. Moroz, L.A. Blood (1981) [Pubmed]
  36. Cutaneous vascular fibrinolytic activity in the local Shwartzman reaction. Bergstein, J.M. Am. J. Pathol. (1977) [Pubmed]
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