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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Eye Banks

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Disease relevance of Eye Banks


High impact information on Eye Banks

  • CONCLUSIONS: Retinal tissue RNA can be analyzed within the time constraints of current eye bank tissue processing, whereas analysis of RPE necessitates either rapid processing or use of RNAlater [4].
  • METHODS: Proteins from microdissected eye bank ocular ciliary body tissue were used to identify the corresponding ANCA antigen [5].
  • METHODS: Eight-millimeter-diameter macular discs from 88 unpaired human eye bank eyes were obtained within 72 hours of death, fixed in 10% neutral buffered formalin, and hemisected horizontally [6].
  • METHODS: The VISX Star (Santa Clara, CA) 193-nm argon fluoride excimer laser was used to ablate the cornea in human eye bank eyes under clinical conditions [7].
  • In 8 of 10 samples taken from patients during cataract surgery and in 7 of 10 eye bank eyes the amount of IL-6 was significantly lower (mean, 10 pg/ml and 136 pg/ml, respectively) [8].

Anatomical context of Eye Banks


Associations of Eye Banks with chemical compounds

  • METHODS: Scleral tissue from 97 human eye bank eyes was tested individually in a two-chamber Ussing apparatus with the following hydrophilic radiolabeled compounds on one side of the chamber: 5-fluorouracil, sucrose, dexamethasone, methotrexate, inulin, and three separate dextran polymers (MWt = 10,000, 40,000, and 70,000) [13].
  • Corneal penetration of sulfonamide carbonic anhydrase inhibitors for topical treatment of glaucoma has been tested in human eye bank and rabbit tissue [14].
  • The concentration of P-choline in 53 clear human lenses was 0.94 mM (+/- 0.31 S.D.) and was relatively unaffected by age, eye bank storage, or freezing [15].
  • Air bubble endothelial damage during phacoemulsification in human eye bank eyes: the protective effects of Healon and Viscoat [16].
  • METHODS: The Sovereign phacoemulsification unit (Allergan) was used in 3 modes in conjunction with the Olson irrigating chopper (ASICO) in 6 fresh human cadaver eye-bank eyes to determine the temperature at which a wound burn would occur [17].

Gene context of Eye Banks

  • Lenses from 42 eye bank eyes were assayed for glutathione peroxidase and glutathione reductase activities [18].
  • METHODS: Twenty-two human whole globes not suitable for transplantation were obtained from an eye bank (San Diego Eye Bank, San Diego, California) and used for study [19].
  • As EGF overcomes H2O2-induced rises in [Ca2+]i, its presence during eye bank storage could improve the outcome of corneal transplant surgery [20].
  • OBJECTIVE: To evaluate the effects of the intrastromal corneal ring, a device developed to reduce myopia, on corneal asphericity in a large set of eye bank eyes [21].
  • After correction for calibration error, the CLC readings on eye bank eyes were 1.00 D higher in average (range +0.45 to +1.90) than those obtained with the SK-1 which gave lower keratometric values at the 2-mm chord diameter (-0.254 D, range: +0.05 to -0.7) [22].

Analytical, diagnostic and therapeutic context of Eye Banks


  1. Low mature TGF-beta 2 levels in aqueous humor during uveitis. de Boer, J.H., Limpens, J., Orengo-Nania, S., de Jong, P.T., La Heij, E., Kijlstra, A. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  2. Phosphatic metabolites in keratoconus. Greiner, J.V., Lass, J.H., Reinhart, W.J., Medcalf, S.K., Glonek, T. Exp. Eye Res. (1989) [Pubmed]
  3. Simultaneous measurement of reduced and oxidized glutathione in human aqueous humor and cataracts by electrochemical detection. Chakrapani, B., Yedavally, S., Leverenz, V., Giblin, F.J., Reddy, V.N. Ophthalmic Res. (1995) [Pubmed]
  4. Stability of RNA from the retina and retinal pigment epithelium in a porcine model simulating human eye bank conditions. Malik, K.J., Chen, C.D., Olsen, T.W. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  5. BetaB1-crystallin: identification of a candidate ciliary body uveitis antigen. Stempel, D., Sandusky, H., Lampi, K., Cilluffo, M., Horwitz, J., Braun, J., Goodglick, L., Gordon, L.K. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  6. The relationships of age changes in retinal pigment epithelium and Bruch's membrane. Okubo, A., Rosa, R.H., Bunce, C.V., Alexander, R.A., Fan, J.T., Bird, A.C., Luthert, P.J. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  7. Human corneal ablation threshold using the 193-nm ArF excimer laser. Berns, M.W., Chao, L., Giebel, A.W., Liaw, L.H., Andrews, J., VerSteeg, B. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  8. Analysis of immunoregulatory cytokines in ocular fluid samples from patients with uveitis. Ongkosuwito, J.V., Feron, E.J., van Doornik, C.E., Van der Lelij, A., Hoyng, C.B., La Heij, E.C., Kijlstra, A. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  9. Secretory response of mast cells contained in monodispersed human choroidal preparations. Miller, S.T., Barney, N.P., Gamache, D.A., Spellman, J.M., Yanni, J.M. Int. Arch. Allergy Immunol. (1997) [Pubmed]
  10. Human choroidal melanocytes in tissue culture. Waldrep, J.C., Kaplan, H.J. Curr. Eye Res. (1986) [Pubmed]
  11. Microvasculature of the human optic nerve. Onda, E., Cioffi, G.A., Bacon, D.R., Van Buskirk, E.M. Am. J. Ophthalmol. (1995) [Pubmed]
  12. Glutathione reductase in human lens epithelium: FAD-induced in vitro activation. Horwitz, J., Dovrat, A., Straatsma, B.R., Revilla, P.J., Lightfoot, D.O. Curr. Eye Res. (1987) [Pubmed]
  13. Human scleral permeability. Effects of age, cryotherapy, transscleral diode laser, and surgical thinning. Olsen, T.W., Edelhauser, H.F., Lim, J.I., Geroski, D.H. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  14. Permeability of human cornea and sclera to sulfonamide carbonic anhydrase inhibitors. Edelhauser, H.F., Maren, T.H. Arch. Ophthalmol. (1988) [Pubmed]
  15. Phosphorylcholine and phosphorylethanolamine in human and rhesus monkey lenses. Jernigan, H.M., Zigler, J.S. Exp. Eye Res. (1989) [Pubmed]
  16. Air bubble endothelial damage during phacoemulsification in human eye bank eyes: the protective effects of Healon and Viscoat. Craig, M.T., Olson, R.J., Mamalis, N., Olson, R.J. Journal of cataract and refractive surgery. (1990) [Pubmed]
  17. Bimanual phacoemulsification through 2 stab incisions. A wound-temperature study. Soscia, W., Howard, J.G., Olson, R.J. Journal of cataract and refractive surgery. (2002) [Pubmed]
  18. Activity of glutathione peroxidase and glutathione reductase in the human lens related to age. Rathbun, W.B., Bovis, M.G. Curr. Eye Res. (1986) [Pubmed]
  19. Viability of limbal epithelium after anterior lamellar harvesting using a microkeratome. Tungsiripat, T., Sarayba, M.A., Taban, M., Sweet, P.M., Osann, K.E., Chuck, R.S. Ophthalmology (2004) [Pubmed]
  20. EGF suppresses hydrogen peroxide induced Ca2+ influx by inhibiting L-type channel activity in cultured human corneal endothelial cells. Mergler, S., Pleyer, U., Reinach, P., Bednarz, J., Dannowski, H., Engelmann, K., Hartmann, C., Yousif, T. Exp. Eye Res. (2005) [Pubmed]
  21. Corneal asphericity in eye bank eyes implanted with the intrastromal corneal ring. Burris, T.E., Holmes-Higgin, D.K., Silvestrini, T.A., Scholl, J.A., Proudfoot, R.A., Baker, P.C. Journal of refractive surgery (Thorofare, N.J. : 1995) (1997) [Pubmed]
  22. Modification, calibration, and comparative testing of an automated surgical keratometer. Simon, G., Parel, J.M., Nose, I., Lee, W. Refractive & corneal surgery. (1991) [Pubmed]
  23. Assessment of the number of lamellae in the central region of the normal human corneal stroma at the resolution of the transmission electron microscope. Bergmanson, J.P., Horne, J., Doughty, M.J., Garcia, M., Gondo, M. Eye & contact lens. (2005) [Pubmed]
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