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MeSH Review

Gelatin Sponge, Absorbable

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Disease relevance of Gelatin Sponge, Absorbable

  • The data show that coinjection of Gelfoam with type 5 adenovirus recombinant for prostate-specific Ag (Ad5-PSA) enhanced CTL activation [1].
  • The study suggested that segmental embolization with Ivalon particles was well tolerated by dogs, and complete hepatic embolization resulted in hepatic function changes and focal infarction comparable with Gelfoam embolization [2].
  • Enlarged gastroesophageal veins were successfully obliterated in 41 patients using embolization with modified autogenous clots and/or Gelfoam, balloon occlusion, iatrogenic perivenous hematoma, sclerosing agents (Sotradecol and Keflin), or a combination of these methods [3].
  • We previously demonstrated that intrastriatal transplantation of fetal striatum or gelfoam protects against toxicity induced by a subsequent intrastriatal injection of quinolinic acid performed one week later [4].
  • Embolization of a traumatic arteriovenous fistula of the scalp with radiopaque Gelfoam pledgets. Case report and technical note [5].

High impact information on Gelatin Sponge, Absorbable

  • To assess the relevance of Src inhibition to angiogenesis, in vivo gelfoam assays were done [6].
  • Gelfoam sponges containing 0.4% agarose and IL-6 or basic fibroblast growth factor and implanted into the subcutis of BALB/c mice were vascularized to the same extent [7].
  • Direct effects of IL-1beta on angiogenesis were investigated by use of an in vivo Gelfoam angiogenesis assay in which IL-1beta produced a significant increase in vessel counts (P = 0.0189) [8].
  • Direct effects of recombinant Ang-1 on angiogenesis were studied with an in vivo Gelfoam angiogenesis assay [9].
  • The protective effect of GDNF was prevented by co-administration to the Gelfoam of neutralizing antibodies recognizing all three TGF-beta isoforms but not GDNF [10].

Chemical compound and disease context of Gelatin Sponge, Absorbable


Biological context of Gelatin Sponge, Absorbable


Anatomical context of Gelatin Sponge, Absorbable

  • A mixture of Gelfoam powder, contrast media, and three drugs (doxorubicin, mitomycin, and cisplatin) was injected under fluoroscopic guidance via a percutaneous catheter into the hepatic artery until stagnation of blood flow was achieved [21].
  • The protein incorporation of [3H] lysine into hemisected rat spinal cord (left side, T2) treated with cycloheximide (100 micrograms/ml in Gelfoam sponge placed in wound at time of lesion) was tested 3 h, 6 h, 12 h, 1, 3, 7, and 14 days later and compared with that in 0.9% saline in Gelfoam implants as normal controls (N = 54) [22].
  • Newborn rat pups received a unilateral sciatic nerve transection and the injury site was treated with gelfoam soaked in phosphate buffered saline (PBS), nerve growth factor (NGF), or LIF [23].
  • At this time FGF-2-ir reappears in astroglia nuclei of cytochrome C-treated animals, but remains undetectable in the striatum carrying the FGF-2-containing gelfoam [24].
  • By day 10, endothelial cells on Gelfoam were found to secrete NO* at a rate exceeding 1.0 microM/h/10(6) cells, concomitant with an enhanced level of NOS II activity [25].

Associations of Gelatin Sponge, Absorbable with chemical compounds

  • Chemoembolization using doxorubicin, lipiodol, and Gelfoam was performed before OLT in 31 patients with good liver function [26].
  • To find effective chemoembolization mixtures, we tested combinations of carboplatin with the embolizates Spherex and Gelfoam in comparison to a therapy with NaCl-solution, a treatment with the cytostatic drug only, and a therapy with each of the embolizates alone [27].
  • A small bilateral lesion in the motor-sensory cortex was performed, and either FGF-2, FGF-2 plus heparan sulfate, heparan sulfate, or saline was applied unilaterally in a piece of Gelfoam within the wound cavity [28].
  • These include Gelfoam, silicone spheres, polyvinyl alcohol foam (PVA), isobutyl-2-cyanoacrylate (IBCA), silicone fluid mixtures, and tantalum powder [29].
  • Transcatheter electrocoagulation (TCEC) was used for vessel occlusion in combination with embolization by Gelfoam and/or Ivalon in six patients in whom other interventional or surgical techniques were considered dangerous or unfeasible [30].

Gene context of Gelatin Sponge, Absorbable

  • Animals that received gelfoam soaked in nerve growth factor, brain derived neurotrophic factor, or ciliary neurotrophic factor at the lesion site also showed a 30% neuron loss at 2 months, and a 40% reduction in average cell area [31].
  • In situ hybridization experiments revealed that cells expressing CNTF mRNA were concentrated at the margin of the wound, and also present within the gelfoam which filled the lesion cavity [32].
  • To demonstrate the utility of this assay for evaluation of an antiangiogenic agent, mice were implanted with gelfoam sponges containing different proangiogenic factors and treated orally with water or PTK 787, a novel tyrosine kinase inhibitor with specific activity against the VEGF-R [33].
  • Class III beta-tubulin isotype, MAP2, and tau protein were also detected by immunoblot in Gelfoam matrix cultures, monolayer cultures, and suspension cultures of D283 Med cells [34].
  • Coinoculation of LNCaP cells with a slowly absorbed matrix (Gelfoam) absorbed with bFGF or dialyzed and concentrated rUGM or MS CM was also capable of inducing LNCaP tumor formation in vivo [35].

Analytical, diagnostic and therapeutic context of Gelatin Sponge, Absorbable


  1. Cutting edge: restoration of the ability to generate CTL in mice immune to adenovirus by delivery of virus in a collagen-based matrix. Siemens, D.R., Elzey, B.D., Lubaroff, D.M., Bohlken, C., Jensen, R.J., Swanson, A.K., Ratliff, T.L. J. Immunol. (2001) [Pubmed]
  2. Experimental canine hepatic artery embolization with polyvinyl alcohol foam particles. Chuang, V.P., Tsai, C.C., Soo, C.S., Wright, K., Wallace, S., Charnsangavej, C. Radiology. (1982) [Pubmed]
  3. New techniques for interruption of gastroesophageal venous blood flow. Pereiras, R., Viamonte, M., Russell, E., LePage, J., White, P., Hutson, D. Radiology. (1977) [Pubmed]
  4. Time course of the neuroprotective effect of transplantation on quinolinic acid-induced lesions of the striatum. Levivier, M., Gash, D.M., Przedborski, S. Neuroscience (1995) [Pubmed]
  5. Embolization of a traumatic arteriovenous fistula of the scalp with radiopaque Gelfoam pledgets. Case report and technical note. Kasdon, D.L., Altemus, L.R., Stein, B.M. J. Neurosurg. (1976) [Pubmed]
  6. Expression and activity of SRC regulate interleukin-8 expression in pancreatic adenocarcinoma cells: implications for angiogenesis. Trevino, J.G., Summy, J.M., Gray, M.J., Nilsson, M.B., Lesslie, D.P., Baker, C.H., Gallick, G.E. Cancer Res. (2005) [Pubmed]
  7. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine. Nilsson, M.B., Langley, R.R., Fidler, I.J. Cancer Res. (2005) [Pubmed]
  8. Interleukin-1beta regulates angiopoietin-1 expression in human endothelial cells. Fan, F., Stoeltzing, O., Liu, W., McCarty, M.F., Jung, Y.D., Reinmuth, N., Ellis, L.M. Cancer Res. (2004) [Pubmed]
  9. Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. Stoeltzing, O., Ahmad, S.A., Liu, W., McCarty, M.F., Wey, J.S., Parikh, A.A., Fan, F., Reinmuth, N., Kawaguchi, M., Bucana, C.D., Ellis, L.M. Cancer Res. (2003) [Pubmed]
  10. Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-beta as cofactor in vivo. Schober, A., Hertel, R., Arumäe, U., Farkas, L., Jaszai, J., Krieglstein, K., Saarma, M., Unsicker, K. J. Neurosci. (1999) [Pubmed]
  11. Arteriovenous malformation of the uterus associated with a missed abortion. Ginsberg, N.A., Hammer, R., Parihk, S., Tamura, R., Sabbagha, R.E. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. (1994) [Pubmed]
  12. Experience with liver resection after hepatic arterial chemoembolization for hepatocellular carcinoma. Yu, Y.Q., Xu, D.B., Zhou, X.D., Lu, J.Z., Tang, Z.Y., Mack, P. Cancer (1993) [Pubmed]
  13. Transhepatic obliteration of esophageal varices using stainless coils combined with hypertonic glucose and gelfoam. Ohnishi, K., Takayasu, K., Takashi, M., Suzuki, N., Hirashima, T., Hara, T., Saito, M., Hatano, H., Nakayama, T., Nomura, F. J. Clin. Gastroenterol. (1985) [Pubmed]
  14. Effects of sodium hyaluronate on peridural fibrosis after lumbar laminotomy and discectomy. Songer, M.N., Ghosh, L., Spencer, D.L. Spine. (1990) [Pubmed]
  15. Hepatic artery embolization for control of symptoms, octreotide requirements, and tumor progression in metastatic carcinoid tumors. Schell, S.R., Camp, E.R., Caridi, J.G., Hawkins, I.F. J. Gastrointest. Surg. (2002) [Pubmed]
  16. Overexpression of elastin fragments in infarcted myocardium attenuates scar expansion and heart dysfunction. Mizuno, T., Mickle, D.A., Kiani, C.G., Li, R.K. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  17. Messenger RNA and protein expression of basic fibroblast growth factor receptor after cortical ablation. Yuguchi, T., Kohmura, E., Yamada, K., Wanaka, A., Otsuki, H., Sakaguchi, T., Yamashita, T., Tohyama, M., Hayakawa, T. Brain Res. Mol. Brain Res. (1994) [Pubmed]
  18. Gelatin-thrombin-based hemostatic sealant for intraoperative bleeding in vascular surgery. Weaver, F.A., Hood, D.B., Zatina, M., Messina, L., Badduke, B. Annals of vascular surgery. (2002) [Pubmed]
  19. Total therapeutic embolization of the kidney for hypertension in a child with a mycotic aneurysm. Cohen, A.M., Fisher, M.F., Yoon, Y.S. Cardiovascular and interventional radiology. (1983) [Pubmed]
  20. Vitamin A-soaked gelfoam sponges and wound healing in steroid-treated animals. Haws, M., Brown, R.E., Suchy, H., Roth, A. Annals of plastic surgery. (1994) [Pubmed]
  21. Chemoembolization for hepatocellular carcinoma. Venook, A.P., Stagg, R.J., Lewis, B.J., Chase, J.L., Ring, E.J., Maroney, T.P., Hohn, D.C. J. Clin. Oncol. (1990) [Pubmed]
  22. [3H]lysine incorporation into protein of hemisected, cycloheximide-treated spinal cord. Bernstein, J.J., Wells, M.R. Exp. Neurol. (1983) [Pubmed]
  23. Leukemia inhibitory factor prevents the death of axotomised sensory neurons in the dorsal root ganglia of the neonatal rat. Cheema, S.S., Richards, L., Murphy, M., Bartlett, P.F. J. Neurosci. Res. (1994) [Pubmed]
  24. Early effects of FGF-2 on glial cells in the MPTP-lesioned striatum. Wirth, S.B., Rufer, M., Unsicker, K. Exp. Neurol. (1996) [Pubmed]
  25. Stable expression of varied levels of inducible nitric oxide synthase in primary cultures of endothelial cells. Zhang, B., Cao, G.L., Domachowske, J., Jackson, M.J., Porasuphatana, S., Rosen, G.M. Anal. Biochem. (2000) [Pubmed]
  26. Survival after liver transplantation in cirrhotic patients with and without hepatocellular carcinoma: a comparative study. Figueras, J., Jaurrieta, E., Valls, C., Benasco, C., Rafecas, A., Xiol, X., Fabregat, J., Casanovas, T., Torras, J., Baliellas, C., Ibañez, L., Moreno, P., Casais, L. Hepatology (1997) [Pubmed]
  27. Evaluation of efficient chemoembolization mixtures by magnetic resonance imaging therapy monitoring: an experimental study on the VX2 tumor in the rabbit liver. Pauser, S., Wagner, S., Lippmann, M., Pohlen, U., Reszka, R., Wolf, K.J., Berger, G. Cancer Res. (1996) [Pubmed]
  28. Regulation of astrocyte proliferation by FGF-2 and heparan sulfate in vivo. Gómez-Pinilla, F., Vu, L., Cotman, C.W. J. Neurosci. (1995) [Pubmed]
  29. Catheter and material selection for transarterial embolization: technical considerations. II. Materials. Berenstein, A., Kricheff, I.I. Radiology. (1979) [Pubmed]
  30. Vessel occlusion with transcatheter electrocoagulation: initial clinical experience. Thompson, W.M., Johnsrude, I.S., Jackson, D.C., McAlister, S., Miller, M.D., Pizzo, S.V. Radiology. (1979) [Pubmed]
  31. Neurotrophin-3 prevents death of axotomized Clarke's nucleus neurons in adult rat. Shibayama, M., Hattori, S., Himes, B.T., Murray, M., Tessler, A. J. Comp. Neurol. (1998) [Pubmed]
  32. Injury-induced regulation of ciliary neurotrophic factor mRNA in the adult rat brain. Ip, N.Y., Wiegand, S.J., Morse, J., Rudge, J.S. Eur. J. Neurosci. (1993) [Pubmed]
  33. Quantitative and qualitative in vivo angiogenesis assay. McCarty, M.F., Baker, C.H., Bucana, C.D., Fidler, I.J. Int. J. Oncol. (2002) [Pubmed]
  34. Neuron-associated class III beta-tubulin, tau, and MAP2 in the D-283 Med cell line and in primary explants of human medulloblastoma. Vinores, S.A., Herman, M.M., Katsetos, C.D., May, E.E., Frankfurter, A. Histochem. J. (1994) [Pubmed]
  35. Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts. Gleave, M., Hsieh, J.T., Gao, C.A., von Eschenbach, A.C., Chung, L.W. Cancer Res. (1991) [Pubmed]
  36. Transcatheter embolization of hepatocellular carcinoma: assessment of efficacy in cases of resection following embolization. Nakamura, H., Tanaka, T., Hori, S., Yoshioka, H., Kuroda, C., Okamura, J., Sakurai, M. Radiology. (1983) [Pubmed]
  37. Chemoembolization with cisplatin, lipiodol and Gelfoam and subsequent systemic chemotherapy with cisplatin and interferon in patients with hepatocellular carcinoma: a non-randomized prospective study. Baur, M., Walter, R., Gebauer, A., Tscholakoff, D., Lochs, H., Mühlbacher, F., Turetschek, K., Binder, R., Hudec, M., Gangl, A., Ferenci, P., Dittrich, C. Int. J. Oncol. (2003) [Pubmed]
  38. A comparative study of the degree of arterial recanalization in kidneys of dogs following transcatheter embolization with eight different materials. Vlahos, L., Benakis, V., Dimakakos, P., Dimopoulos, C., Pontifex, G. Eur. Urol. (1980) [Pubmed]
  39. Polyvinyl alcohol foam-Gelfoam for therapeutic embolization: a synergistic mixture. Horton, J.A., Marano, G.D., Kerber, C.W., Jenkins, J.J., Davis, S. AJNR. American journal of neuroradiology. (1983) [Pubmed]
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