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MeSH Review

Portasystemic Shunt, Surgical

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Disease relevance of Portasystemic Shunt, Surgical


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High impact information on Portasystemic Shunt, Surgical

  • However, eNOS (-/-) mice did develop a substantial portosystemic shunt (0.33% +/- 0.005% vs 84.53% +/- 0.19% shunt), comparable to that seen in wild-type animals after PVL [7].
  • "Salvage" transjugular intrahepatic portosystemic shunts: gastric fundal compared with esophageal variceal bleeding [8].
  • There is no significant difference in CEA level between patients with and without spontaneous or surgical portosystemic shunts, suggesting that high levels are not attributable to bypass of the liver [9].
  • MARS (for molecular adsorbent recirculating system) and the transjugular intrahepatic portosystemic shunt may also improve renal function in these patients [10].
  • Platelet aggregation and platelet-derived growth factor inhibition for prevention of insufficiency of the transjugular intrahepatic portosystemic shunt: a randomized study comparing trapidil plus ticlopidine with heparin treatment [11].

Chemical compound and disease context of Portasystemic Shunt, Surgical


Biological context of Portasystemic Shunt, Surgical


Anatomical context of Portasystemic Shunt, Surgical


Associations of Portasystemic Shunt, Surgical with chemical compounds


Gene context of Portasystemic Shunt, Surgical

  • Repeated assay of protein C activity in seven children following a surgical portosystemic shunt showed a decrease as compared with preoperative values [28].
  • PATIENTS AND METHODS: Plasma adiponectin levels were determined in 87 patients with liver cirrhosis of different aetiologies, seven patients with alcoholic steatohepatitis undergoing systemic anti-TNF-alpha treatment, in 11 patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt implantation and in 21 healthy controls [29].
  • Although originally developed in patients undergoing the transjugular intrahepatic portosystemic shunt (TIPS) procedure, analysis of OPTN data shows that the components of MELD (in particular, bilirubin) have a very strong correlation with mortality in liver transplant candidates [30].
  • Transjugular intrahepatic portosystemic shunt insertion did not induce changes in the peripheral concentration of adrenomedullin, but baseline values of this hormone predicted the degree of hyperdynamic circulation after TIPS [31].
  • After transjugular intrahepatic portosystemic shunt, a rise in creatinine clearance and urinary sodium excretion (+49%; and +53%) was observed together with a marked reduction in plasma aldosterone and renin activity (-59% and -49%) [32].

Analytical, diagnostic and therapeutic context of Portasystemic Shunt, Surgical


  1. Hepatic and intestinal cytochrome P450 3A activity in cirrhosis: effects of transjugular intrahepatic portosystemic shunts. Chalasani, N., Gorski, J.C., Patel, N.H., Hall, S.D., Galinsky, R.E. Hepatology (2001) [Pubmed]
  2. Prevention of portal hypertension and portosystemic shunts by early chronic administration of clonidine in conscious portal vein-stenosed rats. Lin, H.C., Soubrane, O., Lebrec, D. Hepatology (1991) [Pubmed]
  3. Vascular anatomy of duodenal varices: angiographic and histopathological assessments. Hashizume, M., Tanoue, K., Ohta, M., Ueno, K., Sugimachi, K., Kashiwagi, M., Sueishi, K. Am. J. Gastroenterol. (1993) [Pubmed]
  4. Portal hypertension secondary to myelofibrosis: a study of three cases. Alvarez-Larrán, A., Abraldes, J.G., Cervantes, F., Hernández-Guerra, M., Vizzutti, F., Miquel, R., Gilabert, R., Giusti, M., Garcia-Pagan, J.C., Bosch, J. Am. J. Gastroenterol. (2005) [Pubmed]
  5. Stenosis of the suprahepatic inferior vena cava as a complication of transjugular intrahepatic portosystemic shunt in Budd-Chiari patients. Turnes, J., García-Pagán, J.C., González-Abraldes, J., Real, M., Moitinho, E., Gilabert, R., Escorsell, A., Muntanya, X., Ginès, P., Bosch, J., Rodés, J. Liver Transpl. (2001) [Pubmed]
  6. Oral glutamine challenge and magnetic resonance spectroscopy in three patients with congenital portosystemic shunts. Ortiz, M., Córdoba, J., Alonso, J., Rovira, A., Quiroga, S., Jacas, C., Esteban, R., Guardia, J. J. Hepatol. (2004) [Pubmed]
  7. The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice. Theodorakis, N.G., Wang, Y.N., Skill, N.J., Metz, M.A., Cahill, P.A., Redmond, E.M., Sitzmann, J.V. Gastroenterology (2003) [Pubmed]
  8. "Salvage" transjugular intrahepatic portosystemic shunts: gastric fundal compared with esophageal variceal bleeding. Chau, T.N., Patch, D., Chan, Y.W., Nagral, A., Dick, R., Burroughs, A.K. Gastroenterology (1998) [Pubmed]
  9. Diagnostic usefulness of plasma carcinoembryonic antigen levels in acute and chronic liver disease. Bullen, A.W., Losowsky, M.S., Carter, S., Patel, S., Neville, A.M. Gastroenterology (1977) [Pubmed]
  10. Acute renal failure in patients with cirrhosis: perspectives in the age of MELD. Moreau, R., Lebrec, D. Hepatology (2003) [Pubmed]
  11. Platelet aggregation and platelet-derived growth factor inhibition for prevention of insufficiency of the transjugular intrahepatic portosystemic shunt: a randomized study comparing trapidil plus ticlopidine with heparin treatment. Siegerstetter, V., Huber, M., Ochs, A., Blum, H.E., Rössle, M. Hepatology (1999) [Pubmed]
  12. Effect of propranolol on portosystemic collateral circulation estimated by per-rectal portal scintigraphy with technetium-99m pertechnetate. Bołdys, H., Hartleb, M., Rudzki, K., Nowak, A., Nowak, S. J. Hepatol. (1995) [Pubmed]
  13. Serum bilirubin and early mortality after transjugular intrahepatic portosystemic shunts: results of a multivariate analysis. Rajan, D.K., Haskal, Z.J., Clark, T.W. Journal of vascular and interventional radiology : JVIR. (2002) [Pubmed]
  14. Success of medical and surgical management of acute variceal hemorrhage. Holman, J.M., Rikkers, L.F. Am. J. Surg. (1980) [Pubmed]
  15. Role of cirrhosis in the hemodynamic response to hemorrhage in portal hypertension. Burns, R.C., Wu, Y., Sitzmann, J.V. Surgery (1995) [Pubmed]
  16. Systemic and splanchnic endothelin-1 plasma levels in liver cirrhosis before and after transjugular intrahepatic portosystemic shunt (TIPS). Nolte, W., Ehrenreich, H., Wiltfang, J., Pahl, K., Unterberg, K., Kamrowski-Kruck, H., Schindler, C.G., Figulla, H.R., Buchwald, A.B., Hartmann, H., Ramadori, G. Liver (2000) [Pubmed]
  17. Synaptic transmission in ammonia intoxication. Raabe, W. Neurochemical pathology. (1987) [Pubmed]
  18. Management of misplaced or migrated endovascular stents. Slonim, S.M., Dake, M.D., Razavi, M.K., Kee, S.T., Samuels, S.L., Rhee, J.S., Semba, C.P. Journal of vascular and interventional radiology : JVIR. (1999) [Pubmed]
  19. Congenital absence of the portal vein and role of liver transplantation in children. Shinkai, M., Ohhama, Y., Nishi, T., Yamamoto, H., Fujita, S., Take, H., Adachi, M., Tachibana, K., Aida, N., Kato, K., Tanaka, Y., Takemiya, S. J. Pediatr. Surg. (2001) [Pubmed]
  20. High-intensity basal ganglia lesions on T1-weighted images in two toddlers with elevated blood manganese with portosystemic shunts. Ihara, K., Hijii, T., Kuromaru, R., Ariyoshi, M., Kira, R., Fukushige, J., Hara, T. Neuroradiology. (1999) [Pubmed]
  21. Cerebrospinal fluid glutamine, tryptophan, and tryptophan metabolite concentrations in dogs with portosystemic shunts. Holt, D.E., Washabau, R.J., Djali, S., Dayrell-Hart, B., Drobatz, K.J., Heyes, M.P., Robinson, M.B. Am. J. Vet. Res. (2002) [Pubmed]
  22. Intermittent bleeding from anorectal varices. Fick, T.E., van Buuren, H.R., Huisman, A.M., Schreve, R.H., Terpstra, O.T. The Netherlands journal of surgery. (1985) [Pubmed]
  23. Increased blood manganese in cirrhotic patients: relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms. Spahr, L., Butterworth, R.F., Fontaine, S., Bui, L., Therrien, G., Milette, P.C., Lebrun, L.H., Zayed, J., Leblanc, A., Pomier-Layrargues, G. Hepatology (1996) [Pubmed]
  24. Renal sodium retention complicating alcoholic liver disease: relation to portosystemic shunting and liver function. Rector, W.G., Lewis, F., Robertson, A.D., Everson, G.T. Hepatology (1990) [Pubmed]
  25. Effects of long-term administration of octreotide in portal vein-stenosed rats. Lin, H.C., Yang, M.C., Hou, M.C., Li, S.M., Huang, Y.T., Yu, P.C., Tsai, Y.T., Lee, S.D. Hepatology (1996) [Pubmed]
  26. Effect of L-ornithine-L-aspartate on patients with and without TIPS undergoing glutamine challenge: a double blind, placebo controlled trial. Rees, C.J., Oppong, K., Al Mardini, H., Hudson, M., Record, C.O. Gut (2000) [Pubmed]
  27. Survival following infusion of Pitressin into the superior mesenteric artery to control bleeding esophageal varices in cirrhotic patients. Getzen, L.C., Brink, R.R., Wolfman, E.F. Ann. Surg. (1978) [Pubmed]
  28. Protein C, protein S and antithrombin III in children with portal vein obstruction. Dubuisson, C., Boyer-Neumann, C., Wolf, M., Meyer, D., Bernard, O. J. Hepatol. (1997) [Pubmed]
  29. Circulating adiponectin reflects severity of liver disease but not insulin sensitivity in liver cirrhosis. Kaser, S., Moschen, A., Kaser, A., Ludwiczek, O., Ebenbichler, C.F., Vogel, W., Jaschke, W., Patsch, J.R., Tilg, H. J. Intern. Med. (2005) [Pubmed]
  30. Application of a continuous disease severity score to the OPTN liver waiting list. Edwards, E.B., Harper, A.M. Clinical transplants. (2001) [Pubmed]
  31. Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation. Fernández-Rodriguez, C.M., Prada, I.R., Prieto, J., Montuenga, L.M., Elssasser, T., Quiroga, J., Moreiras, M., Andrade, A., Cuttitta, F. J. Hepatol. (1998) [Pubmed]
  32. Changes in plasma endothelin-1 and Big endothelin-1 induced by transjugular intrahepatic portosystemic shunts in patients with cirrhosis and refractory ascites. Martinet, J.P., Legault, L., Cernacek, P., Roy, L., Dufresne, M.P., Spahr, L., Fenyves, D., Pomier-Layrargues, G. J. Hepatol. (1996) [Pubmed]
  33. Arterioportal fistula: a role for pre-TIPSS arteriography and hepatic venous pressure measurements. Shields, S.J., Byse, B.H., Grace, N.D. Am. J. Gastroenterol. (1992) [Pubmed]
  34. Quantitative evaluation of the hepatic functional reserve using technetium-99m DTPA-galactosyl human serum albumin before and after transjugular intrahepatic portosystemic shunt. Kira, T., Tomiguchi, S., Kira, M., Ohyama, Y., Takahashi, M. European journal of nuclear medicine. (1997) [Pubmed]
  35. Liver transplantation for uncontrollable variceal bleeding. Ewaga, H., Keeffe, E.B., Dort, J., Concepcion, W., Esquivel, C.O. Am. J. Gastroenterol. (1994) [Pubmed]
  36. High occlusion rate in experimental transjugular intrahepatic portosystemic shunt created with a Dacron-covered nitinol stent. Otal, P., Rousseau, H., Vinel, J.P., Ducoin, H., Hassissene, S., Joffre, F. Journal of vascular and interventional radiology : JVIR. (1999) [Pubmed]
  37. Measurement of collateral circulation blood flow in anesthetized portal hypertensive rats. Oberti, F., Maïga, M.Y., Veal, N., Fort, J., Kaassis, M., Moal, F., Villemin, E., Aubé, C., Pilette, C., Rifflet, H., Trouvé, R., Rousselet, M.C., Calès, P. Gastroenterol. Clin. Biol. (1998) [Pubmed]
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