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Disease relevance of Taiwan

  • The ability to induce this differentiation at very low concentrations stimulated investigators to administer a phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), to patients with myeloid leukemias in the People's Republic of China (Z. T. Han et al., Proc. Natl. Acad. Sci. USA, 95: 5357-5361, 1998) [1].
  • To evaluate the effectiveness of Vi polysaccharide vaccine (Vi vaccine) in preventing typhoid fever, an analysis was done of an outbreak of typhoid fever among students attending a middle school in the People's Republic of China, where Vi vaccine is licensed for use [2].
  • CONCLUSIONS: To our knowledge, this is the first report of SPG4 mutations in the People's Republic of China. The percentage of involved Chinese families with autosomal dominant hereditary spastic paraplegia with an SPG4 mutation is 18% (4/22), lower than the estimated 40% linked to this locus [3].
  • Forty-seven corn samples were collected in 1989 from Linxian and Shangqiu Counties in Henan Province, the high- and low-risk areas, respectively, for human esophageal cancer in the People's Republic of China. The samples were analyzed for fumonisin (fumonisin B1 [FB1] and FB2) contamination [4].
  • IMP-1 metallo-beta-lactamase-producing Pseudomonas aeruginosa in a university hospital in the People's Republic of China [5].

High impact information on Taiwan


Chemical compound and disease context of Taiwan


Biological context of Taiwan


Anatomical context of Taiwan

  • Progress in experimental pathology in the People's Republic of China. Action of pppA2'p5'A2'p5'A on the immune system [17].
  • SETTINGS: Subjects selected from the Spinal Cord Injury Association of the Republic of China (SCIAROC) and from the Asylum Center Spinal Cord Injury (ASCCI) in Taiwan. METHODS: Information was obtained from a survey sent to the subjects who are chosen randomly from the SCIAROC and from all the subjects through ACSCI training program [18].

Associations of Taiwan with chemical compounds

  • A randomised double-blind intervention trial was carried out in Huixian, Henan Province, People's Republic of China, to determine whether combined treatment with retinol, riboflavine, and zinc could lower the prevalence of precancerous lesions of the oesophagus [19].
  • Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in Guangxi Autonomous Region, People's Republic of China [20].
  • Field effectiveness of Vi polysaccharide typhoid vaccine in the People's Republic of China [21].
  • The susceptibilities of the N. gonorrhoeae strains were tested to determine the prevalence of ciprofloxacin-resistant strains in Anhui Province, People's Republic of China. Conventional DNA sequencing was also performed to identify mutations in gyrA and parC and to confirm the biochip data [22].
  • The cholinoceptor antagonists anisodamine and anisodine are widely used in the People's Republic of China for the management of acute circulatory shock but the mechanism of their beneficial effects is not fully known; we therefore investigated if these agents possessed adrenoceptor blocking properties [23].

Gene context of Taiwan

  • We conducted a trial in the People's Republic of China in which reduced-dose recombinant tPA was compared with the standard local therapy, urokinase [24].
  • Residents of Qidong, People's Republic of China, are at high risk for development of hepatocellular carcinoma, in part from consumption of foods contaminated with aflatoxins [25].
  • Elevated HPRT mutation frequencies in aflatoxin-exposed residents of daxin, Qidong county, People's Republic of China [26].
  • To explore whether there are ethnic differences in relationships among parathyroid hormone (PTH), vitamin D, and bone mineral status, 352 healthy volunteers, 60-83 years old, were studied in Shenyang, Peoples' Republic of China (108 men, 110 women), and in Cambridge, UK (67 men, 67 women), in late winter [27].
  • Protamine (Shanghai Biochemistry Pharmaceutical Co., People's Republic of China) was injected subcutaneously as an angiogenesis inhibitor [28].

Analytical, diagnostic and therapeutic context of Taiwan


  1. Administration of a phorbol ester to patients with hematological malignancies: preliminary results from a phase I clinical trial of 12-O-tetradecanoylphorbol-13-acetate. Strair, R.K., Schaar, D., Goodell, L., Aisner, J., Chin, K.V., Eid, J., Senzon, R., Cui, X.X., Han, Z.T., Knox, B., Rabson, A.B., Chang, R., Conney, A. Clin. Cancer Res. (2002) [Pubmed]
  2. An outbreak of typhoid fever, Xing-An County, People's Republic of China, 1999: estimation of the field effectiveness of Vi polysaccharide typhoid vaccine. Yang, H.H., Kilgore, P.E., Yang, L.H., Park, J.K., Pan, Y.F., Kim, Y., Lee, Y.J., Xu, Z.Y., Clemens, J.D. J. Infect. Dis. (2001) [Pubmed]
  3. Three novel mutations of the spastin gene in Chinese patients with hereditary spastic paraplegia. Tang, B., Zhao, G., Xia, K., Pan, Q., Luo, W., Shen, L., Long, Z., Dai, H., Zi, X., Jiang, H. Arch. Neurol. (2004) [Pubmed]
  4. Fumonisin occurrence in corn from high- and low-risk areas for human esophageal cancer in China. Yoshizawa, T., Yamashita, A., Luo, Y. Appl. Environ. Microbiol. (1994) [Pubmed]
  5. IMP-1 metallo-beta-lactamase-producing Pseudomonas aeruginosa in a university hospital in the People's Republic of China. Wang, C.X., Mi, Z.H. J. Antimicrob. Chemother. (2004) [Pubmed]
  6. Anisodamine inhibits thromboxane synthesis, granulocyte aggregation, and platelet aggregation. A possible mechanism for its efficacy in bacteremic shock. Xiu, R.J., Hammerschmidt, D.E., Coppo, P.A., Jacob, H.S. JAMA (1982) [Pubmed]
  7. Medical school curriculum in the People's Republic of China. Progress report after 4 1/2 years of experience. Dimond, G.E. JAMA (1976) [Pubmed]
  8. Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China. Wang, J.S., Shen, X., He, X., Zhu, Y.R., Zhang, B.C., Wang, J.B., Qian, G.S., Kuang, S.Y., Zarba, A., Egner, P.A., Jacobson, L.P., Muñoz, A., Helzlsouer, K.J., Groopman, J.D., Kensler, T.W. J. Natl. Cancer Inst. (1999) [Pubmed]
  9. Consumption of salted fish and other risk factors for nasopharyngeal carcinoma (NPC) in Tianjin, a low-risk region for NPC in the People's Republic of China. Ning, J.P., Yu, M.C., Wang, Q.S., Henderson, B.E. J. Natl. Cancer Inst. (1990) [Pubmed]
  10. Randomized, placebo-controlled, esophageal squamous cell cancer chemoprevention trial of selenomethionine and celecoxib. Limburg, P.J., Wei, W., Ahnen, D.J., Qiao, Y., Hawk, E.T., Wang, G., Giffen, C.A., Wang, G., Roth, M.J., Lu, N., Korn, E.L., Ma, Y., Caldwell, K.L., Dong, Z., Taylor, P.R., Dawsey, S.M. Gastroenterology (2005) [Pubmed]
  11. Arsenic trioxide in the treatment of a patient with multiply recurrent, ATRA-resistant promyelocytic leukemia: a case report. Bergstrom, S.K., Gillan, E., Quinn, J.J., Altman, A.J. J. Pediatr. Hematol. Oncol. (1998) [Pubmed]
  12. Cystic echinococcosis in the Xinjiang/Uygur Autonomous Region, People's Republic of China. II. Comparison of three levels of a local preventive and control program. Andersen, F.L., Tolley, H.D., Schantz, P.M., Chi, P., Liu, F., Ding, Z. Trop. Med. Parasitol. (1991) [Pubmed]
  13. Treatment of urgency and urge incontinence with flavoxate in the People's Republic of China. Gu, F.L., Reng, Z.Y., Shang, G.Z., Shao, H.X., Wang, B., Cheng, Z.D., Jiang, Y., Zhao, W.P., Zheng, J.F., Qu, C.T. J. Int. Med. Res. (1987) [Pubmed]
  14. Epidemiology of epilepsy in urban areas of the People's Republic of China. Li, S.C., Schoenberg, B.S., Wang, C.C., Cheng, X.M., Zhou, S.S., Bolis, C.L. Epilepsia (1985) [Pubmed]
  15. Comparison of surgically induced astigmatism after sutureless temporal clear corneal and scleral frown incisions. Huang, F.C., Tseng, S.H. Journal of cataract and refractive surgery. (1998) [Pubmed]
  16. Pregnancy interruption with RU 486 in combination with dl-15-methyl-prostaglandin-F2 alpha-methyl ester: the Chinese experience. Gao, J., Qiao, G.M., Wu, Y.M., Wu, M.E., Zheng, S.R., Han, Z.B., Fan, H.M., Yao, G.Z., Meng, U., Dubois, C. Contraception. (1988) [Pubmed]
  17. Progress in experimental pathology in the People's Republic of China. Action of pppA2'p5'A2'p5'A on the immune system. Liu, X.Y. J. Exp. Pathol. (1984) [Pubmed]
  18. Functional ability, perceived exertion and employment of the individuals with spinal cord lesion in Taiwan. Wang, R.Y., Yang, Y.R., Yen, L.L., Lieu, F.K. Spinal Cord (2002) [Pubmed]
  19. No effect of riboflavine, retinol, and zinc on prevalence of precancerous lesions of oesophagus. Randomised double-blind intervention study in high-risk population of China. Muñoz, N., Wahrendorf, J., Bang, L.J., Crespi, M., Thurnham, D.I., Day, N.E., Ji, Z.H., Grassi, A., Yan, L.W., Lin, L.G. Lancet (1985) [Pubmed]
  20. Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in Guangxi Autonomous Region, People's Republic of China. Groopman, J.D., Zhu, J.Q., Donahue, P.R., Pikul, A., Zhang, L.S., Chen, J.S., Wogan, G.N. Cancer Res. (1992) [Pubmed]
  21. Field effectiveness of Vi polysaccharide typhoid vaccine in the People's Republic of China. Arya, S.C. J. Infect. Dis. (2002) [Pubmed]
  22. Detection of gyrA and parC mutations associated with ciprofloxacin resistance in Neisseria gonorrhoeae by use of oligonucleotide biochip technology. Zhou, W., Du, W., Cao, H., Zhao, J., Yang, S., Li, W., Shen, Y., Zhang, S., Du, W., Zhang, X. J. Clin. Microbiol. (2004) [Pubmed]
  23. Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of rats. Varma, D.R., Yue, T.L. Br. J. Pharmacol. (1986) [Pubmed]
  24. A randomized trial confirming the efficacy of reduced dose recombinant tissue plasminogen activator in a Chinese myocardial infarction population and demonstrating superiority to usual dose urokinase: the TUCC trial. Ross, A.M., Gao, R., Coyne, K.S., Chen, J., Yao, K., Yang, Y., Qin, X., Qiao, S., Yao, M. Am. Heart J. (2001) [Pubmed]
  25. Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer. Egner, P.A., Wang, J.B., Zhu, Y.R., Zhang, B.C., Wu, Y., Zhang, Q.N., Qian, G.S., Kuang, S.Y., Gange, S.J., Jacobson, L.P., Helzlsouer, K.J., Bailey, G.S., Groopman, J.D., Kensler, T.W. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  26. Elevated HPRT mutation frequencies in aflatoxin-exposed residents of daxin, Qidong county, People's Republic of China. Wang, S.S., O'Neill, J.P., Qian, G.S., Zhu, Y.R., Wang, J.B., Armenian, H., Zarba, A., Wang, J.S., Kensler, T.W., Cariello, N.F., Groopman, J.D., Swenberg, J.A. Carcinogenesis (1999) [Pubmed]
  27. Older people in China and the United Kingdom differ in the relationships among parathyroid hormone, vitamin D, and bone mineral status. Yan, L., Zhou, B., Wang, X., D'Ath, S., Laidlaw, A., Laskey, M.A., Prentice, A. Bone (2003) [Pubmed]
  28. Evaluation of the effect of protamine on human prostate carcinoma PC-3m using contrast enhanced Doppler ultrasound. Tang, J., Li, S., Li, J., Zhang, Y., Li, X., Dong, B., Shi, H., Zhang, G. J. Urol. (2003) [Pubmed]
  29. Oltipraz chemoprevention trial in Qidong, People's Republic of China: results of urine genotoxicity assays as related to smoking habits. Camoirano, A., Bagnasco, M., Bennicelli, C., Cartiglia, C., Wang, J.B., Zhang, B.C., Zhu, Y.R., Qian, G.S., Egner, P.A., Jacobson, L.P., Kensler, T.W., De Flora, S. Cancer Epidemiol. Biomarkers Prev. (2001) [Pubmed]
  30. A cross-sectional study of human serum sphingolipids, diet and physiologic parameters. Abnet, C.C., Borkowf, C.B., Qiao, Y.L., Albert, P.S., Wang, E., Merrill, A.H., Mark, S.D., Dong, Z.W., Taylor, P.R., Dawsey, S.M. J. Nutr. (2001) [Pubmed]
  31. A case-control study of thyroid cancer in women under age 55 in Shanghai (People's Republic of China). Preston-Martin, S., Jin, F., Duda, M.J., Mack, W.J. Cancer Causes Control (1993) [Pubmed]
  32. Digital retroilluminated photography to analyze posterior capsule opacification in eyes with intraocular lenses. Wang, M.C., Woung, L.C. Journal of cataract and refractive surgery. (2000) [Pubmed]
  33. Smokers and urinary genotoxins: implications for selection of cohorts and modulation of endpoints in chemoprevention trials. De Flora, S., Camoirano, A., Bagnasco, M., Bennicelli, C., van Zandwijk, N., Wigbout, G., Qian, G.S., Zhu, Y.R., Kensler, T.W. J. Cell. Biochem. Suppl. (1996) [Pubmed]
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