Disease relevance of Epithalamus

• Chronic-intermittent hypoxia induces immediate early gene expression in the midline thalamus and epithalamus [1].
• The epithalamus displayed dense networks of varicose fibers in the ganglion habenulae, but only a few fibers were seen in the organon subcommissurale [2].

High impact information on Epithalamus

• We have focused our attention on the developing forebrain where PLZF is transcribed in a transverse, segment-like domain corresponding to the anterior pretectum, in the alarmost part of the dorsal thalamus, in the epithalamus, and in the hypothalamus along a defined longitudinal subdomain [3].
• Distribution of substance P neurons in the epithalamus of the rat: an immunohistochemical investigation [4].
• Substance P (SP) immunoreactivity was studied in the epithalamus of intact and superior cervical ganglionectomized female rats by using the peroxidase-antiperoxidase immunocytochemical technique [4].
• GABA neurons of epithalamus are derived from the embryonic pretectum [5].
• The distribution of nicotine, cytisine, and epibatidine bindings corresponds broadly to the patterns observed in rodents, with the marked exception of the epithalamus [6].

Biological context of Epithalamus

• The study demonstrates a peculiar developmental pattern, with transient downregulation, of asymmetric calretinin expression in the frog epithalamus [7].
• In adult brain, we detected tyrosinase promoter activity in cortex, olfactory system, hippocampus, epithalamus and substantia nigra, areas corresponding to positive staining during embryogenesis [8].

Anatomical context of Epithalamus

• Immature SP-positive cells initially appear at embryonic day 12 (E12) in the epithalamus and in a column of cells extending from the myelencephalon throughout the length of the neural tube [9].
• These results indicate that pineal modified photoreceptors and parafollicular pinealocyte-like cells represent the two populations of melatonin-producing cells of the chicken epithalamus [10].
• Finally, gfi1 is expressed in the developing epithalamus in the dorsal diencephalon where its transcription is restricted to the parapineal [11].
• Zebrafish nrp1a is expressed in the neural tube including telencephalon, epithalamus, cells along the axonal trajectory of the posterior commissure and the medial longitudinal fascicle, hindbrain neurons, vagus motor neurons and spinal motoneurons [12].

Associations of Epithalamus with chemical compounds

• GABA and serotonin (5-HT) pattern in the supraependymal fibers of the rat epithalamus: combined radioautographic and immunocytochemical studies. Effect of 5-HT content on [3H]GABA accumulation [13].

Gene context of Epithalamus

• Localization of hydroxyindole O-methyltransferase-synthesizing cells in bovine epithalamus: immunocytochemistry and in-situ hybridization [14].
• The Nodal signalling pathway regulates laterality by biasing an otherwise stochastic laterality decision to the left side of the epithalamus [15].
• Thus, diencephalic segments p1 and p3 have alar cell populations contributing to the longitudinal premotor connectivity of the neural axis , whereas the alar p2 segment projects via the fasciculus retroflexus, the efferent tract of the epithalamus [16].

References