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Zbtb16  -  zinc finger and BTB domain containing 16

Mus musculus

Synonyms: AI467657, Green's luxoid, PLZF, Zfp145, lu
 
 
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Disease relevance of Zbtb16

 

High impact information on Zbtb16

 

Biological context of Zbtb16

  • Developmental analysis of murine Promyelocyte Leukemia Zinc Finger (PLZF) gene expression: implications for the neuromeric model of the forebrain organization [5].
  • To elucidate its role, we isolated the murine PLZF gene and studied its expression during embryogenesis [5].
  • During mid to late gestation PLZF is expressed in restricted domains of the developing CNS as well as in specific organs and body structures [5].
  • Zfp145-/- mice also exhibit anterior-directed homeotic transformation throughout the axial skeleton with associated alterations in Hox gene expression [6].
  • The high degree of evolutionary conservation between the patterns of PLZF expression during mammalian and avian central nervous system development suggests that it has an important functional role in the regionalization of the vertebrate hindbrain, potentially regulating boundary cell interactions [7].
 

Anatomical context of Zbtb16

  • Our data suggest a role for PLZF in the establishment and maintenance of transverse identities, longitudinal subdomains, and interneuromeric boundaries, providing additional evidences in favor of the neuromeric organization of the forebrain [5].
  • Combined analysis with other regionally restricted genes, such as Orthopedia and Dlx1, indicates that in the hypothalamus the PLZF domain is contained within that of Orthopedia and both are complementary to that of Dlx1 [5].
  • We have focused our attention on the developing forebrain where PLZF is transcribed in a transverse, segment-like domain corresponding to the anterior pretectum, in the alarmost part of the dorsal thalamus, in the epithalamus, and in the hypothalamus along a defined longitudinal subdomain [5].
  • At E 8.5, PLZF is transcribed in most of the endoderm [5].
  • Zfp145 expression was restricted to gonocytes and undifferentiated spermatogonia and was absent in tubules of W/W(v) mutants that lack these cells [3].
 

Associations of Zbtb16 with chemical compounds

  • To investigate the role of oligomerization for the transformation potential of X-ABL and for the sensitivity to STI571, we constructed ABL chimeras with oligomerization interfaces of proteins involved in leukemia-associated translocations such as BCR, TEL, PML, and PLZF [8].
  • Histone lysine trimethylation exhibits a distinct perinuclear distribution in Plzf-expressing spermatogonia [9].
 

Other interactions of Zbtb16

  • Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development [10].
 

Analytical, diagnostic and therapeutic context of Zbtb16

References

  1. Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A. Yeyati, P.L., Shaknovich, R., Boterashvili, S., Li, J., Ball, H.J., Waxman, S., Nason-Burchenal, K., Dmitrovsky, E., Zelent, A., Licht, J.D. Oncogene (1999) [Pubmed]
  2. Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis. Piazza, F., Costoya, J.A., Merghoub, T., Hobbs, R.M., Pandolfi, P.P. Mol. Cell. Biol. (2004) [Pubmed]
  3. Essential role of Plzf in maintenance of spermatogonial stem cells. Costoya, J.A., Hobbs, R.M., Barna, M., Cattoretti, G., Manova, K., Sukhwani, M., Orwig, K.E., Wolgemuth, D.J., Pandolfi, P.P. Nat. Genet. (2004) [Pubmed]
  4. Plzf is required in adult male germ cells for stem cell self-renewal. Buaas, F.W., Kirsh, A.L., Sharma, M., McLean, D.J., Morris, J.L., Griswold, M.D., de Rooij, D.G., Braun, R.E. Nat. Genet. (2004) [Pubmed]
  5. Developmental analysis of murine Promyelocyte Leukemia Zinc Finger (PLZF) gene expression: implications for the neuromeric model of the forebrain organization. Avantaggiato, V., Pandolfi, P.P., Ruthardt, M., Hawe, N., Acampora, D., Pelicci, P.G., Simeone, A. J. Neurosci. (1995) [Pubmed]
  6. Plzf regulates limb and axial skeletal patterning. Barna, M., Hawe, N., Niswander, L., Pandolfi, P.P. Nat. Genet. (2000) [Pubmed]
  7. Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain. Cook, M., Gould, A., Brand, N., Davies, J., Strutt, P., Shaknovich, R., Licht, J., Waxman, S., Chen, Z., Gluecksohn-Waelsch, S. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  8. Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571. Beissert, T., Puccetti, E., Bianchini, A., Güller, S., Boehrer, S., Hoelzer, D., Ottmann, O.G., Nervi, C., Ruthardt, M. Blood (2003) [Pubmed]
  9. Histone lysine trimethylation exhibits a distinct perinuclear distribution in Plzf-expressing spermatogonia. Payne, C., Braun, R.E. Dev. Biol. (2006) [Pubmed]
  10. Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development. Barna, M., Pandolfi, P.P., Niswander, L. Nature (2005) [Pubmed]
  11. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Schefe, J.H., Menk, M., Reinemund, J., Effertz, K., Hobbs, R.M., Pandolfi, P.P., Ruiz, P., Unger, T., Funke-Kaiser, H. Circ. Res. (2006) [Pubmed]
 
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