The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Transplantation Tolerance

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Transplantation Tolerance

  • In this study immune deviation into a Th2 (IL-4) response was associated with, but did not insure, graft tolerance, as the inopportune timing of B7 blockade with CTLA4/Ig therapy prevented uniform tolerance but did not prevent Th2-type immune deviation [1].
  • The correlation of increased spontaneous production of IL 3 during this period leads us to postulate that this interleukin may be implicated in the activation or clonal expansion of suppressor cells, and hence may play a role in graft tolerance [2].
  • Cyclosporine therapy of rat heart allograft recipients and release of interleukins (IL 1, IL 2, IL 3): a role for IL 3 in graft tolerance [2]?
  • CONCLUSIONS: The decrease in T-cell proliferation and Th1 cytokines TNF-alpha and IL-2, may be one basis of altered immunoregulation resulting in increased rates of certain types of infections and increased graft tolerance reported in patients receiving poststorage LD blood transfusions [3].
  • Because apoptosis is required for the development of graft tolerance, induction strategies that use IL-2-independent pathways may be advantageous [4].
 

Biological context of Transplantation Tolerance

 

Associations of Transplantation Tolerance with chemical compounds

  • However, skin graft tolerance to bm1 antigens was induced when B6 mice were injected with anti-Thy1.2 mAb on day -1 and bm1 cells on day 0 followed by CP on day 2 [9].
  • Toward a myeloablative regimen with clinical potential: II. Treosulfan induces specific skin graft tolerance across haploidentical MHC barriers [10].
  • This may be due to enhanced renal graft tolerance induced by the simultaneously grafted liver, in addition to the reduced risk of oxalate-induced damage to the kidney graft because the oxalate overproduction has been corrected [11].
  • In an attempt to induce graft tolerance, low-dose cyclosporin A (CsA) was administered to some animals for 20 weeks, then gradually withdrawn [12].
 

Gene context of Transplantation Tolerance

  • Interestingly in BOS, the number of IL5- and IL10-producing cells was significantly lower than in stable patients (P < or = .05), suggesting a possible role of these Th2 cytokines in the modulation of graft tolerance [13].
  • We further asked whether modulation of HO-1 expression/activity could be used to promote the induction of graft tolerance [8].
  • We show that bm12 vIL-10-transduced DC administration in CD8-/- C57BL/6 mice promoted IFN-gamma production, down-regulated TH2-type cytokine production, and did not induce skin graft tolerance [14].
  • CONCLUSIONS: Highly disparate xenogeneic pig skin graft tolerance can be achieved by grafting FP THY alone in anti-CD4 and anti-CD8 mAb-treated ATX B6 mice, but not in euthymic B6 mice [15].
  • Additional treatment of ATX recipient mice with anti-Thy1.2 and NK1.1 mAbs and 3 Gy TBI is not essential for donor pig skin graft tolerance induction [15].
 

Analytical, diagnostic and therapeutic context of Transplantation Tolerance

References

  1. CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment. Zheng, X.X., Markees, T.G., Hancock, W.W., Li, Y., Greiner, D.L., Li, X.C., Mordes, J.P., Sayegh, M.H., Rossini, A.A., Strom, T.B. J. Immunol. (1999) [Pubmed]
  2. Cyclosporine therapy of rat heart allograft recipients and release of interleukins (IL 1, IL 2, IL 3): a role for IL 3 in graft tolerance? Abbud-Filho, M., Kupiec-Weglinski, J.W., Araujo, J.L., Heidecke, C.D., Tilney, N.L., Strom, T.B. J. Immunol. (1984) [Pubmed]
  3. Poststorage leuko-depleted plasma inhibits T-cell proliferation and Th1 response in vitro: characterization of TGFbeta-1 as an important immunomodulatory component in stored blood. Hodge, G.L., Hodge, S.J., Nairn, J., Tippett, E., Holmes, M., Reynolds, P.N. Transplantation (2005) [Pubmed]
  4. Differential effects of interleukin-2 blockade on apoptosis in naïve and activated human lymphocytes. Woodside, K.J., Hu, M., Meng, T., Hunter, G.C., Sower, L.E., Daller, J.A. Transplantation (2003) [Pubmed]
  5. Blocking B7 and CD40 co-stimulatory molecules decreases antiviral T cell activity. Vermeiren, J., Ceuppens, J.L., Haegel-Kronenberger, H., De Boer, M., Boon, L., Van Gool, S.W. Clin. Exp. Immunol. (2004) [Pubmed]
  6. An alternative conditioning regimen for induction of specific skin graft tolerance across full major histocompatibility complex barriers. de Vries-van der Zwan, A., van der Pol, M.A., de Waal, L.P., Boog, C.J. Transpl. Immunol. (1998) [Pubmed]
  7. Thymic weight in pantothenic acid deficiency. Mahboob, S. Nutrition and metabolism. (1976) [Pubmed]
  8. Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs. Yamashita, K., Ollinger, R., McDaid, J., Sakahama, H., Wang, H., Tyagi, S., Csizmadia, E., Smith, N.R., Soares, M.P., Bach, F.H. FASEB J. (2006) [Pubmed]
  9. Prevention of induction of unresponsiveness to class I antigens by veto activity of donor marrow in cylophosphamide-treated mice. Tomita, Y., Nomoto, K. Transplantation (1993) [Pubmed]
  10. Toward a myeloablative regimen with clinical potential: II. Treosulfan induces specific skin graft tolerance across haploidentical MHC barriers. van Pel, M., van Breugel, D.W., Vos, W., Ploemacher, R.E., Boog, C.J. Bone Marrow Transplant. (2004) [Pubmed]
  11. Combined liver-kidney and isolated liver transplantations for primary hyperoxaluria type 1: the European experience. The European Study Group on Transplantation in Hyperoxaluria Type 1. Watts, R.W., Danpure, C.J., De Pauw, L., Toussaint, n.u.l.l. Nephrol. Dial. Transplant. (1991) [Pubmed]
  12. Immunosuppression in nerve allografting: is it desirable? Ansselin, A.D., Pollard, J.D., Davey, D.F. J. Neurol. Sci. (1992) [Pubmed]
  13. The frequency of interleukin-10- and interleukin-5-secreting CD4+ T cells correlates to tolerance of transplanted lung. Bianco, A.M., Solari, N., Miserere, S., Pellegrini, C., Vitulo, P., Pozzi, E., Fietta, A., Meloni, F. Transplant. Proc. (2005) [Pubmed]
  14. Unexpected effects of viral interleukin-10-secreting dendritic cells in vivo: preferential inhibition of TH2 responses. Moore, F., Buonocore, S., Paulart, F., Thielemans, K., Goldman, M., Flamand, V. Transplant. Proc. (2004) [Pubmed]
  15. Highly disparate xenogeneic skin graft tolerance induction by fetal pig thymus in thymectomized mice: Conditioning requirements and the role of coimplantation of fetal pig liver. Zhao, Y., Rodriguez-Barbosa, J.I., Swenson, K., Zhao, G., Arn, J.S., Sykes, M. Transplantation (2001) [Pubmed]
  16. Host thymectomy and cyclosporine lead to unstable skin graft tolerance after class I mismatched allogeneic neonatal thymic transplantation in mice. Rodríguez-Barbosa, J.I., Haller, G.W., Zhao, G., Sachs, D.H., Sykes, M. Transpl. Immunol. (2005) [Pubmed]
 
WikiGenes - Universities