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Disease relevance of Caesalpinia


High impact information on Caesalpinia

  • A proteinase inhibitor from Caesalpinia echinata (pau-brasil) seeds for plasma kallikrein, plasmin and factor XIIa [3].
  • We recently showed that Tarapod tannic acid (TA), a hydrolyzable tannin extracted from the pods of the Tara tree (Caesalpinia spinosa), was more effective than other tannins tested at inhibiting ultraviolet-B (UV-B)-stimulated hydrogen peroxide activity (an indirect measure of free radicals) in the skin of hairless mice [4].
  • Previously we reported that brazilin, the main principle of Caesalpinia sappan, was able to improve the altered immune functions caused by halothane administration in mice [5].
  • Brazilein (6a,7-dihydro-3,6a,10-trihydroxy-benz[b]indeno[1,2-d]pyran-9(6H)-one) is a compound obtained in a large amount from Caesalpinia sappan ethanol extracts with a high purity of about 98% [6].
  • A new cassane diterpenoid, caesaldecan, was isolated from Caesalpinia decapetala with eight known compounds, spathulenol, 4,5-epoxy-8(14)-caryophyllene, squalene, lupeol, trans-resveratrol, quercetin, astragalin, and stigmasterol [7].

Biological context of Caesalpinia


Anatomical context of Caesalpinia


Associations of Caesalpinia with chemical compounds

  • A bioassay-guided study led to the isolation of five new cassane furanoditerpenes, designated as caesalmin C (1), D (2), E (3), F (4), and G (5), along with stigmasterol (6) from the seeds of Caesalpinia minax [11].
  • Pulcherralpin, a new diterpene ester from Caesalpinia pulcherrima [12].
  • Xanthine oxidase inhibitors from the heartwood of Vietnamese Caesalpinia sappan [13].
  • Two new flavanoids, 5,7-dimethoxy-3',4'-methylenedioxyflavanone and isobonducellin along with 2'-hydroxy-2,3,4',6'-tetramethoxychalcone, 5,7-dimethoxyflavone and bonducellin were isolated from the aerial parts of Caesalpinia pulcherrima [14].
  • An asparagine-linked sugar chain of a protease inhibitor from barbados pride (Caesalpinia pulcherrima Sw.) was liberated by hydrazinolysis [15].

Gene context of Caesalpinia

  • In addition, the extracts of A. debilis, Caesalpinia sappan, Curcuma longa, C. zedoaria, Daphne genkwa and Morus alba were also considered as potential inhibitors of iNOS activity (>70% inhibition at the test concentration of 10 micro g/ml) [16].
  • The effect of Caesalpinia sappan extract on MRSA invasion appeared dose-dependent [10].
  • Aldose reductase inhibitors from the fruits of Caesalpinia ferrea Mart [17].
  • Ethanolic extract (70%) of Caesalpinia bonducella seed kernel has been subjected for its antipyretic and antinociceptive activities in adult albino rats or mice of either sex at 30, 100 and 300 mg/kg orally [18].
  • The crude aqueous extract of the fruits of Caesalpinia ferrea Mart [19].

Analytical, diagnostic and therapeutic context of Caesalpinia

  • Powdered fruits of Terminalia chebula and powdered pod cover of Caesalpinia digyna was used in the process and the different process parameters for maximum production of tannase and gallic acid by co-culture method were optimized through media engineering [20].


  1. Alkyl gallates, intensifiers of beta-lactam susceptibility in methicillin-resistant Staphylococcus aureus. Shibata, H., Kondo, K., Katsuyama, R., Kawazoe, K., Sato, Y., Murakami, K., Takaishi, Y., Arakaki, N., Higuti, T. Antimicrob. Agents Chemother. (2005) [Pubmed]
  2. Antitumor activity and antioxidant status of Caesalpinia bonducella against Ehrlich ascites carcinoma in Swiss albino mice. Gupta, M., Mazumder, U.K., Kumar, R.S., Sivakumar, T., Vamsi, M.L. J. Pharmacol. Sci. (2004) [Pubmed]
  3. A proteinase inhibitor from Caesalpinia echinata (pau-brasil) seeds for plasma kallikrein, plasmin and factor XIIa. Cruz-Silva, I., Gozzo, A.J., Nunes, V.A., Carmona, A.K., Faljoni-Alario, A., Oliva, M.L., Sampaio, M.U., Sampaio, C.A., Araujo, M.S. Biol. Chem. (2004) [Pubmed]
  4. Tannins protect against skin tumor promotion induced by ultraviolet-B radiation in hairless mice. Gali-Muhtasib, H.U., Yamout, S.Z., Sidani, M.M. Nutrition and cancer. (2000) [Pubmed]
  5. Brazilin modulates immune function mainly by augmenting T cell activity in halothane administered mice. Choi, S.Y., Yang, K.M., Jeon, S.D., Kim, J.H., Khil, L.Y., Chang, T.S., Moon, C.K. Planta Med. (1997) [Pubmed]
  6. Study on cardioactive effects of brazilein. Zhao, Y.N., Pan, Y., Tao, J.L., Xing, D.M., Du, L.J. Pharmacology (2006) [Pubmed]
  7. Caesaldecan, a cassane diterpenoid from the leaves of Caesalpinia decapetala. Kiem, P.V., Minh, C.V., Huong, H.T., Lee, J.J., Kim, Y.H. Chem. Pharm. Bull. (2005) [Pubmed]
  8. Molecular structures and antiviral activities of naturally occurring and modified cassane furanoditerpenoids and friedelane triterpenoids from Caesalpinia minax. Jiang, R.W., Ma, S.C., He, Z.D., Huang, X.S., But, P.P., Wang, H., Chan, S.P., Ooi, V.E., Xu, H.X., Mak, T.C. Bioorg. Med. Chem. (2002) [Pubmed]
  9. Effects of methanol extracts of Caesalpinia bonducella and Bauhinia racemosa on hematology and hepatorenal function in mice. Kumar, R.S., Gupta, M., Mazumdar, U.K., Rajeshwar, Y., Kumar, T.S., Gomathi, P., Roy, R. The Journal of toxicological sciences. (2005) [Pubmed]
  10. Inhibitory effects of Caesalpinia sappan on growth and invasion of methicillin-resistant Staphylococcus aureus. Kim, K.J., Yu, H.H., Jeong, S.I., Cha, J.D., Kim, S.M., You, Y.O. Journal of ethnopharmacology. (2004) [Pubmed]
  11. New antiviral cassane furanoditerpenes from Caesalpinia minax. Jiang, R.W., Ma, S.C., But, P.P., Mak, T.C. J. Nat. Prod. (2001) [Pubmed]
  12. Pulcherralpin, a new diterpene ester from Caesalpinia pulcherrima. Che, C.T., McPherson, D.D., Cordell, G.A., Fong, H.H. J. Nat. Prod. (1986) [Pubmed]
  13. Xanthine oxidase inhibitors from the heartwood of Vietnamese Caesalpinia sappan. Nguyen, M.T., Awale, S., Tezuka, Y., Tran, Q.L., Kadota, S. Chem. Pharm. Bull. (2005) [Pubmed]
  14. Flavanoids from Caesalpinia pulcherrima. Srinivas, K.V., Koteswara Rao, Y., Mahender, I., Das, B., Rama Krishna, K.V., Hara Kishore, K., Murty, U.S. Phytochemistry (2003) [Pubmed]
  15. Structure of a sugar chain of a protease inhibitor isolated from barbados pride (Caesalpinia pulcherrima Sw.) seeds. Hase, S., Koyama, S., Daiyasu, H., Takemoto, H., Hara, S., Kobayashi, Y., Kyogoku, Y., Ikenaka, T. J. Biochem. (1986) [Pubmed]
  16. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. Hong, C.H., Hur, S.K., Oh, O.J., Kim, S.S., Nam, K.A., Lee, S.K. Journal of ethnopharmacology. (2002) [Pubmed]
  17. Aldose reductase inhibitors from the fruits of Caesalpinia ferrea Mart. Ueda, H., Tachibana, Y., Moriyasu, M., Kawanishi, K., Alves, S.M. Phytomedicine (2001) [Pubmed]
  18. Antipyretic and analgesic activities of Caesalpinia bonducella seed kernel extract. Archana, P., Tandan, S.K., Chandra, S., Lal, J. Phytotherapy research : PTR. (2005) [Pubmed]
  19. Preliminary studies of analgesic and anti-inflammatory properties of Caesalpinia ferrea crude extract. Carvalho, J.C., Teixeira, J.R., Souza, P.J., Bastos, J.K., dos Santos Filho, D., Sarti, S.J. Journal of ethnopharmacology. (1996) [Pubmed]
  20. Microbial transformation of tannin-rich substrate to gallic acid through co-culture method. Banerjee, R., Mukherjee, G., Patra, K.C. Bioresour. Technol. (2005) [Pubmed]
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