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Disease relevance of Lepidium

  • The toxicities of copper, chromium, cadmium, nickel, manganese, zinc, and lead ions and various concentrations of mixtures of them were studied using the aquatic plant Spirodela polyrrhiza and the terrestrial plant Lepidium sativum [1].

Psychiatry related information on Lepidium


High impact information on Lepidium


Associations of Lepidium with chemical compounds

  • Since prostaglandins inhibit the proliferation of CTC in response to PHA or IL-2 (R.D. Maca (1983) Immunopharmacology 6:267), studies were undertaken to determine if the observed inhibition was mediated by effects of F5 on prostaglandin E2 (PGE2) [8].
  • Imidazole alkaloids from Lepidium meyenii [9].
  • A study with plants revealed no effect of HCFC-141b on seed germination and growth of wheat (Triticum aestivum), radish (Raphanus sativus), and cress (Lepidium sativum) [10].
  • The tubers of Lepidium meyenii contain the benzylated derivative of 1,2-dihydro-N-hydroxypyridine, named macaridine, together with the benzylated alkamides (macamides), N-benzyl-5-oxo-6E,8E-octadecadienamide and N-benzylhexadecanamide, as well as the acyclic keto acid, 5-oxo-6E,8E-octadecadienoic acid [11].
  • The use of Lepidium sativum in a plant bioassay system for the detection of microcystin-LR [12].

Gene context of Lepidium

  • The essential oil profile of maca (Lepidium meyenii) obtained from Lima, Peru, was examined [13].
  • Their effects on the germination and growth of the dicots Lactuca sativa (cv. Nigra and cv. Roman), Lepidium sativum, and Lycopersicon esculentum and the monocots Allium cepa, Hordeum vulgare, and Triticum aestivum as standard target species have been studied [14].
  • This study aimed at testing the hypothesis that Maca contains testosterone-like compounds, able to bind the human androgen receptor and promote transcription pathways regulated by steroid hormone signaling [15].
  • METHODS: Mice were treated with 80 mg/kg of malathion in the presence or absence of an aqueous extract of Maca, which was orally administered 7, 14 or 21 days after injection of the malathion [16].

Analytical, diagnostic and therapeutic context of Lepidium


  1. Assessment of toxic interactions of heavy metals in a multicomponent mixture using Lepidium sativum and Spirodela polyrrhiza. Montvydiene, D., Marciulioniene, D. Environ. Toxicol. (2004) [Pubmed]
  2. Nutrients and botanicals for erectile dysfunction: examining the evidence. McKay, D. Alternative medicine review : a journal of clinical therapeutic. (2004) [Pubmed]
  3. The myrosinase-glucosinolate interaction mechanism studied using some synthetic competitive inhibitors. Iori, R., Rollin, P., Streicher, H., Thiem, J., Palmieri, S. FEBS Lett. (1996) [Pubmed]
  4. Gravity induced changes in intracellular potentials in statocytes of cress roots. Sievers, A., Sondag, C., Trebacz, K., Hejnowicz, Z. Planta (1995) [Pubmed]
  5. Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men. Gonzales, G.F., Córdova, A., Vega, K., Chung, A., Villena, A., Góñez, C. J. Endocrinol. (2003) [Pubmed]
  6. Evomonoside: the cytotoxic cardiac glycoside from Lepidium apetalum. Hyun, J.W., Shin, J.E., Lim, K.H., Sung, M.S., Park, J.W., Yu, J.H., Kim, B.K., Paik, W.H., Kang, S.S., Park, J.G. Planta Med. (1995) [Pubmed]
  7. The polarity of statocytes and the gravisensitivity of roots are dependent on the concentration of calcium in statocytes. Wendt, M., Sievers, A. Plant Cell Physiol. (1989) [Pubmed]
  8. Suppressive effect of thymosin fraction 5 on proliferation of cultured human T lymphocytes. Wolf, R.E., Maca, R.D. Immunopharmacology (1986) [Pubmed]
  9. Imidazole alkaloids from Lepidium meyenii. Cui, B., Zheng, B.L., He, K., Zheng, Q.Y. J. Nat. Prod. (2003) [Pubmed]
  10. Biodegradation and ecotoxicity of HFCs and HCFCs. Berends, A.G., de Rooij, C.G., Shin-ya, S., Thompson, R.S. Arch. Environ. Contam. Toxicol. (1999) [Pubmed]
  11. Constituents of Lepidium meyenii 'maca'. Muhammad, I., Zhao, J., Dunbar, D.C., Khan, I.A. Phytochemistry (2002) [Pubmed]
  12. The use of Lepidium sativum in a plant bioassay system for the detection of microcystin-LR. Gehringer, M.M., Kewada, V., Coates, N., Downing, T.G. Toxicon (2003) [Pubmed]
  13. Composition of the essential oil of Lepidium meyenii (Walp). Tellez, M.R., Khan, I.A., Kobaisy, M., Schrader, K.K., Dayan, F.E., Osbrink, W. Phytochemistry (2002) [Pubmed]
  14. Natural and synthetic podolactones with potential use as natural herbicide models. Macías, F.A., Simonet, A.M., Pacheco, P.C., Barrero, A.F., Cabrera, E., Jiménez-González, D. J. Agric. Food Chem. (2000) [Pubmed]
  15. Lepidium meyenii (Maca) does not exert direct androgenic activities. Bogani, P., Simonini, F., Iriti, M., Rossoni, M., Faoro, F., Poletti, A., Visioli, F. Journal of ethnopharmacology. (2006) [Pubmed]
  16. Lepidium meyenii (Maca) reduces spermatogenic damage induced by a single dose of malathion in mice. Bustos-Obregon, E., Yucra, S., Gonzales, G.F. Asian J. Androl. (2005) [Pubmed]
  17. Red maca (Lepidium meyenii) reduced prostate size in rats. Gonzales, G.F., Miranda, S., Nieto, J., Fernández, G., Yucra, S., Rubio, J., Yi, P., Gasco, M. Reprod. Biol. Endocrinol. (2005) [Pubmed]
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