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Disease relevance of Mangifera

  • Mangiferin (MGN), a glucosylxanthone derived from Mangifera indica (mango), was investigated for its ability to reduce the frequency of radiation-induced micronucleated binucleate cells (MNBNCs) in cultured human peripheral blood lymphocytes (HPBLs) [1].
  • The observation that acute allergic contact dermatitis can arise on first exposure to mango in patients who have been sensitized beforehand by contact with other urushiol-containing plants has been documented previously [2].
  • The objective of this study was to evaluate postprandial blood glucose response to mango and sapota in comparison to banana in patients with diabetes mellitus Type 2 [3].

High impact information on Mangifera

  • RESULTS: Reactive proteins of approximately 30 to 45 kd (putative class I chitinases) were recognized by both specific polyclonal antibodies to chitinases and sera from patients with latex-fruit allergy in chestnut, cherimoya, passion fruit, kiwi, papaya, mango, tomato, and flour wheat extracts [4].
  • Within 50 amino acids surrounding the cysteine, considered to be part of the thiolase active site, the kiwifruit protein shows approximately 26% sequence identity with the mango, cucumber, and rat peroxisomal thiolases [5].
  • This coincides with the time of year of maximum vitamin A (VA) intake-the mango season [6].
  • Antioxidant activity of the mango juice and juice extracts was measured by 3 standard in vitro methods [7].
  • To test the effectiveness of mango supplementation, 176 Gambian children, aged 2 to 7 y, were randomly assigned to one of four treatments: 75 g of dried mango containing approximately 150 micro g retinol activity equivalents with (MF) or without (M) 5 g of fat, 5 d/wk for 4 mo or 60,000 micro g of vitamin A (A) or placebo (P) capsule at baseline [8].

Biological context of Mangifera

  • The predicted amino-acid sequence exhibited 62, 64 and 68% identity to the S. guttatum, soybean, and A. thaliana enzymes respectively, indicating that this cDNA encodes a mango homologue of the alternative oxidase [9].
  • All eight components, but especially the carotenoids: lycopene, alpha- and beta-carotene, exhibited a major seasonal variation, with maximum levels between May and July, corresponding to the end of the "mango" season and the beginning of the "rainy" season [10].
  • The present study investigated the effects of orally administered Vimang (an aqueous extract of Mangifera indica) and mangiferin (the major polyphenol present in Vimang) on mouse antibody responses induced by inoculation with spores of microsporidian parasites [11].

Anatomical context of Mangifera

  • In the present study, the alcoholic extract of stem bark of Mangifera indica Linn (Extract I containing mangiferin 2.6%), has been investigated for its effect on cell mediated and humoral components of the immune system in mice [12].
  • An aqueous stem bark extract of Mangifera indica (Vimang) inhibits T cell proliferation and TNF-induced activation of nuclear transcription factor NF-kappaB [13].

Associations of Mangifera with chemical compounds

  • Anti-allergic properties of Mangifera indica L. extract (Vimang) and contribution of its glucosylxanthone mangiferin [14].
  • Then over a 4-day interval, a solution of tomato juice, peach juice, mango juice, dextrose and a chocolate beverage (Ensure Plus), all made isocaloric to the alcohol solutions with dextrose, was placed in the third tube simultaneously with water and the individually preferred concentration of alcohol.(ABSTRACT TRUNCATED AT 250 WORDS)[15]
  • A rapid method for quantitative determination of beta-carotene, including cis-isomers, in dried mango has been developed [16].
  • There was no effect of consecutive yearly applications on the amount of paclobutrazol residues in mango fruit [17].
  • Fruit antioxidant activity, ascorbic acid, total phenol, quercetin, and carotene of Irwin mango fruits stored at low temperature after high electric field pretreatment [18].

Gene context of Mangifera


Analytical, diagnostic and therapeutic context of Mangifera


  1. Effect of mangiferin on radiation-induced micronucleus formation in cultured human peripheral blood lymphocytes. Jagetia, G.C., Venkatesha, V.A. Environ. Mol. Mutagen. (2005) [Pubmed]
  2. Exploring the mango-poison ivy connection: the riddle of discriminative plant dermatitis. Hershko, K., Weinberg, I., Ingber, A. Contact Derm. (2005) [Pubmed]
  3. Postprandial glucose response to mango, banana and sapota. Contractor, Z., Hussain, F., Jabbar, A. JPMA. The Journal of the Pakistan Medical Association. (1999) [Pubmed]
  4. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. Diaz-Perales, A., Collada, C., Blanco, C., Sanchez-Monge, R., Carrillo, T., Aragoncillo, C., Salcedo, G. J. Allergy Clin. Immunol. (1999) [Pubmed]
  5. Identification of a chloroplast coenzyme A-binding protein related to the peroxisomal thiolases. Yang, L.M., Lamppa, G. Plant Physiol. (1996) [Pubmed]
  6. Innate immunity, gut integrity, and vitamin A in Gambian and Indian infants. Thurnham, D.I., Northrop-Clewes, C.A., McCullough, F.S., Das, B.S., Lunn, P.G. J. Infect. Dis. (2000) [Pubmed]
  7. Neoplastic Transformation of BALB/3T3 Cells and Cell Cycle of HL-60 Cells are Inhibited by Mango (Mangifera indica L.) Juice and Mango Juice Extracts. Percival, S.S., Talcott, S.T., Chin, S.T., Mallak, A.C., Lounds-Singleton, A., Pettit-Moore, J. J. Nutr. (2006) [Pubmed]
  8. A randomized, 4-month mango and fat supplementation trial improved vitamin A status among young Gambian children. Drammeh, B.S., Marquis, G.S., Funkhouser, E., Bates, C., Eto, I., Stephensen, C.B. J. Nutr. (2002) [Pubmed]
  9. Alternative oxidase from mango (Mangifera indica, L.) is differentially regulated during fruit ripening. Cruz-Hernández, A., Gómez-Lim, M.A. Planta (1995) [Pubmed]
  10. Plasma carotenoid and vitamin E concentrations in women living in a rural west African (Gambian) community. Bates, C.J., Matthews, N., West, B., Morison, L., Walraven, G. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (2002) [Pubmed]
  11. Mangifera indica L. extract (Vimang) and mangiferin modulate mouse humoral immune responses. García, D., Leiro, J., Delgado, R., Sanmartín, M.L., Ubeira, F.M. Phytotherapy research : PTR. (2003) [Pubmed]
  12. Immunomodulatory activity of alcoholic extract of Mangifera indica L. in mice. Makare, N., Bodhankar, S., Rangari, V. Journal of ethnopharmacology. (2001) [Pubmed]
  13. An aqueous stem bark extract of Mangifera indica (Vimang) inhibits T cell proliferation and TNF-induced activation of nuclear transcription factor NF-kappaB. Garrido, G., Blanco-Molina, M., Sancho, R., Macho, A., Delgado, R., Muñoz, E. Phytotherapy research : PTR. (2005) [Pubmed]
  14. Anti-allergic properties of Mangifera indica L. extract (Vimang) and contribution of its glucosylxanthone mangiferin. Rivera, D.G., Balmaseda, I.H., León, A.A., Hernández, B.C., Montiel, L.M., Garrido, G.G., Cuzzocrea, S., Hernández, R.D. J. Pharm. Pharmacol. (2006) [Pubmed]
  15. Tomato juice, chocolate drink, and other fluids suppress volitional drinking of alcohol in the female Syrian golden hamster. Piercy, K.T., Myers, R.D. Physiol. Behav. (1995) [Pubmed]
  16. Quantitative determination of beta-carotene stereoisomers in fresh, dried, and solar-dried mangoes (Mangifera indica L.). Pott, I., Marx, M., Neidhart, S., Mühlbauer, W., Carle, R. J. Agric. Food Chem. (2003) [Pubmed]
  17. Uptake of soil applied paclobutrazol in mango (Mangifera indica L.) and its persistence in fruit and soil. Sharma, D., Awasthi, M.D. Chemosphere (2005) [Pubmed]
  18. Fruit antioxidant activity, ascorbic acid, total phenol, quercetin, and carotene of Irwin mango fruits stored at low temperature after high electric field pretreatment. Shivashankara, K.S., Isobe, S., Al-Haq, M.I., Takenaka, M., Shiina, T. J. Agric. Food Chem. (2004) [Pubmed]
  19. Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production on macrophages and microglia by a standard aqueous extract of Mangifera indica L. (VIMANG). Role of mangiferin isolated from the extract. Garrido, G., Delgado, R., Lemus, Y., Rodríguez, J., García, D., Núñez-Sellés, A.J. Pharmacol. Res. (2004) [Pubmed]
  20. A rab11-like gene is developmentally regulated in ripening mango (Mangifera indica L.) fruit. Zainal, Z., Tucker, G.A., Lycett, G.W. Biochim. Biophys. Acta (1996) [Pubmed]
  21. Study of respiratory impairment among pesticide sprayers in Mango plantations. Rastogi, S.K., Gupta, B.N., Husain, T., Mathur, N., Garg, N. Am. J. Ind. Med. (1989) [Pubmed]
  22. Production and characterisation of monoclonal antibodies to phytoene synthase of Lycopersicon esculentum. Fraser, P.D., Misawa, N., Sandmann, G., Johnson, J., Schuch, W., Bramley, P.M. Phytochemistry (1998) [Pubmed]
  23. Field evaluation of a phototoxic dye, phloxine B, against three species of fruit flies (Diptera: Tephritidae). Moreno, D.S., Celedonio, H., Mangan, R.L., Zavala, J.L., Montoya, P. J. Econ. Entomol. (2001) [Pubmed]
  24. Capillary electrophoresis analysis of mangiferin extracted from Mangifera indica L. bark and Mangifera persiciformis C.Y. Wu et T.L. Ming leaves. Nong, C., He, W., Fleming, D., Pan, L., Huang, H. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2005) [Pubmed]
  25. Mango seed uses: thermal behaviour of mango seed almond fat and its mixtures with cocoa butter. Solís-Fuentes, J.A., Durán-de-Bazúa, M.C. Bioresour. Technol. (2004) [Pubmed]
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