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MeSH Review

Deep Brain Stimulation

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Disease relevance of Deep Brain Stimulation


Psychiatry related information on Deep Brain Stimulation


High impact information on Deep Brain Stimulation


Chemical compound and disease context of Deep Brain Stimulation


Biological context of Deep Brain Stimulation


Anatomical context of Deep Brain Stimulation


Associations of Deep Brain Stimulation with chemical compounds

  • This case establishes the potential for addiction to deep brain stimulation and demonstrates that widespread behavioral and physiological changes, with concomitant alteration in the regional cerebral metabolic rate for glucose, may accompany unilateral thalamic stimulation [20].
  • Gabapentine has been assessed for efficacy in some tremors, and deep brain stimulation of the ventrolateral thalamus has been shown to be safer and more effective for severe essential and parkinsonian tremor than thalamotomy [21].
  • Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats [22].
  • The authors report a new technique to anchor deep brain stimulation electrodes using a titanium microplate [23].
  • Chronic bilateral subthalamic deep brain stimulation in a patient with homozygous deletion in the parkin gene [24].

Gene context of Deep Brain Stimulation


Analytical, diagnostic and therapeutic context of Deep Brain Stimulation


  1. Dyskinesias and grip control in Parkinson's disease are normalized by chronic stimulation of the subthalamic nucleus. Wenzelburger, R., Zhang, B.R., Poepping, M., Schrader, B., Müller, D., Kopper, F., Fietzek, U., Mehdorn, H.M., Deuschl, G., Krack, P. Ann. Neurol. (2002) [Pubmed]
  2. Bilateral globus pallidus stimulation for Huntington's disease. Moro, E., Lang, A.E., Strafella, A.P., Poon, Y.Y., Arango, P.M., Dagher, A., Hutchison, W.D., Lozano, A.M. Ann. Neurol. (2004) [Pubmed]
  3. Interactions between deep brain stimulation and levodopa in Parkinson's disease. Nutt, J.G., Rufener, S.L., Carter, J.H., Anderson, V.C., Pahwa, R., Hammerstad, J.P., Burchiel, K.J. Neurology (2001) [Pubmed]
  4. Deep brain stimulation of subthalamic area for severe proximal tremor. Kitagawa, M., Murata, J., Kikuchi, S., Sawamura, Y., Saito, H., Sasaki, H., Tashiro, K. Neurology (2000) [Pubmed]
  5. Pathophysiologic basis of surgery for Parkinson's disease. Obeso, J.A., Rodriguez-Oroz, M.C., Rodriguez, M., Macias, R., Alvarez, L., Guridi, J., Vitek, J., DeLong, M.R. Neurology (2000) [Pubmed]
  6. Effects of pallidal deep brain stimulation and levodopa treatment on reaction-time performance in Parkinson's disease. Schubert, T., Volkmann, J., Müller, U., Sturm, V., Voges, J., Freund, H.J., Von Cramon, D.Y. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (2002) [Pubmed]
  7. Deep brain stimulation of the GPi treats restless legs syndrome associated with dystonia. Okun, M.S., Fernandez, H.H., Foote, K.D. Mov. Disord. (2005) [Pubmed]
  8. Deep brain stimulation of the subthalamic nucleus enhances emotional processing in Parkinson disease. Schneider, F., Habel, U., Volkmann, J., Regel, S., Kornischka, J., Sturm, V., Freund, H.J. Arch. Gen. Psychiatry (2003) [Pubmed]
  9. Deep brain stimulation for dystonia: make the lame walk. Vidailhet, M., Pollak, P. Ann. Neurol. (2005) [Pubmed]
  10. Deep brain stimulation for refractory obsessive-compulsive disorder. Abelson, J.L., Curtis, G.C., Sagher, O., Albucher, R.C., Harrigan, M., Taylor, S.F., Martis, B., Giordani, B. Biol. Psychiatry (2005) [Pubmed]
  11. Blood flow responses to deep brain stimulation of thalamus. Perlmutter, J.S., Mink, J.W., Bastian, A.J., Zackowski, K., Hershey, T., Miyawaki, E., Koller, W., Videen, T.O. Neurology (2002) [Pubmed]
  12. Unilateral deep brain stimulation of the internal globus pallidus alleviates tardive dyskinesia. Schrader, C., Peschel, T., Petermeyer, M., Dengler, R., Hellwig, D. Mov. Disord. (2004) [Pubmed]
  13. Chemoarchitectonic heterogeneities in the primate zona incerta: clinical and functional implications. Mitrofanis, J., Ashkan, K., Wallace, B.A., Benabid, A.L. J. Neurocytol. (2004) [Pubmed]
  14. EEG and evoked potential recording from the subthalamic nucleus for deep brain stimulation of intractable epilepsy. Dinner, D.S., Neme, S., Nair, D., Montgomery, E.B., Baker, K.B., Rezai, A., Lüders, H.O. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2002) [Pubmed]
  15. Striatal dopaminergic metabolism is increased by deep brain stimulation of the subthalamic nucleus in 6-hydroxydopamine lesioned rats. Meissner, W., Reum, T., Paul, G., Harnack, D., Sohr, R., Morgenstern, R., Kupsch, A. Neurosci. Lett. (2001) [Pubmed]
  16. Release of beta-endorphin and methionine-enkephalin into cerebrospinal fluid during deep brain stimulation for chronic pain. Effects of stimulation locus and site of sampling. Young, R.F., Bach, F.W., Van Norman, A.S., Yaksh, T.L. J. Neurosurg. (1993) [Pubmed]
  17. How does deep brain stimulation work? Present understanding and future questions. McIntyre, C.C., Savasta, M., Walter, B.L., Vitek, J.L. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. (2004) [Pubmed]
  18. Neuroprotection trek--the next generation: neuromodulation I. Techniques--deep brain stimulation, vagus nerve stimulation, and transcranial magnetic stimulation. Andrews, R.J. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  19. Reversibility of chronic neurologic deficits. Some effects of electrical stimulation of the thalamus and internal capsule in man. Cooper, I.S., Upton, A.R., Amin, I. Applied neurophysiology. (1980) [Pubmed]
  20. Compulsive thalamic self-stimulation: a case with metabolic, electrophysiologic and behavioral correlates. Portenoy, R.K., Jarden, J.O., Sidtis, J.J., Lipton, R.B., Foley, K.M., Rottenberg, D.A. Pain (1986) [Pubmed]
  21. Tremor. Deuschl, G., Wenzelburger, R., Raethjen, J. Curr. Opin. Neurol. (2000) [Pubmed]
  22. Deep brain stimulation of subthalamic neurons increases striatal dopamine metabolism and induces contralateral circling in freely moving 6-hydroxydopamine-lesioned rats. Meissner, W., Harnack, D., Paul, G., Reum, T., Sohr, R., Morgenstern, R., Kupsch, A. Neurosci. Lett. (2002) [Pubmed]
  23. Anchoring of deep brain stimulation electrodes using a microplate. Technical note. Favre, J., Taha, J.M., Steel, T., Burchiel, K.J. J. Neurosurg. (1996) [Pubmed]
  24. Chronic bilateral subthalamic deep brain stimulation in a patient with homozygous deletion in the parkin gene. Capecci, M., Passamonti, L., Annesi, F., Annesi, G., Bellesi, M., Candiano, I.C., Ricciuti, R., Iacoangeli, M., Scerrati, M., Zappia, M., Tarantino, P., De Marco, E.V., Civitelli, D., Carrideo, S., Provinciali, L., Ceravolo, M.G., Quattrone, A. Mov. Disord. (2004) [Pubmed]
  25. Emerging treatments in Parkinson's disease. Albanese, A. Eur. Neurol. (1997) [Pubmed]
  26. Dystonia: clinical features, genetics, and treatment. Klein, C., Ozelius, L.J. Curr. Opin. Neurol. (2002) [Pubmed]
  27. Learning networks in health and Parkinson's disease: reproducibility and treatment effects. Carbon, M., Ghilardi, M.F., Feigin, A., Fukuda, M., Silvestri, G., Mentis, M.J., Ghez, C., Moeller, J.R., Eidelberg, D. Human brain mapping. (2003) [Pubmed]
  28. Obsessive-compulsive disorder: development of demand-controlled deep brain stimulation with methods from stochastic phase resetting. Tass, P.A., Klosterkötter, J., Schneider, F., Lenartz, D., Koulousakis, A., Sturm, V. Neuropsychopharmacology (2003) [Pubmed]
  29. Central nystagmus induced by deep-brain stimulation for epilepsy. Taylor, R.B., Wennberg, R.A., Lozano, A.M., Sharpe, J.A. Epilepsia (2000) [Pubmed]
  30. Complex locking rather than complete cessation of neuronal activity in the globus pallidus of a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primate in response to pallidal microstimulation. Bar-Gad, I., Elias, S., Vaadia, E., Bergman, H. J. Neurosci. (2004) [Pubmed]
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