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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Monodelphis


Psychiatry related information on Monodelphis


High impact information on Monodelphis

  • With two different antibodies (a monoclonal antibody to the C terminus of the 31-kd subunit of H-ATPase and a polyclonal rabbit antiserum to whole bovine H-ATPase) the vacuolar-type H-ATPase pump in the different nephron segments of the gray short-tailed (Monodelphis domestica) opossum kidney has been immunocytochemically localized [8].
  • Examination of a metatherian mammal, the gray short-tailed opossum (Monodelphis domestica) revealed seven canonical OR37 genes, all phylogenetically related to cluster II genes and also organized similar to cluster II of eutherian species [9].
  • The p53 tumor suppressor gene of the marsupial Monodelphis domestica: cloning of exons 4-11 and mutations in exons 5-8 in ultraviolet radiation-induced corneal sarcomas [1].
  • We report the cDNA sequences for the DMA and DMB family of Mhc genes of the gray short-tailed opossum [10].
  • Transthyretin was found in serum from Monodelphis domestica, Didelphis virginiana, Caluromys lanatus, and Dromiciops australis [11].

Biological context of Monodelphis


Anatomical context of Monodelphis

  • This study involved characterization of Leydig cells of the opossum Monodelphis domestica, functionally by immunocytochemical identification of the enzyme 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) and by measurement of testosterone levels using RIA [15].
  • Here retinal ganglion cells in the opossum Monodelphis were birthdated with tritiated thymidine on the sixth postnatal day (P6), before being lesioned in the temporal retina at P8 [16].
  • We have previously shown that when the central nervous system (CNS) of the new-born opossum, Monodelphis domestica, is cultured for three to five days in the presence of histidine, inhibition by baclofen, a GABAB agonist, disappears (Stewart et al. 1991) [17].
  • Intraperitoneal administration of 0.5 mg toremifene daily for 5 days in three female animals resulted in a mean uterus concentration of 22.9 nmol/g, or 400-fold that achieved by topical administration of 0.5 mg/day in three other female Monodelphis (0.05 nmol/g) [3].
  • In the presence of diaminobenzidine (DAB), a laser microbeam was applied to carbocyanine (Dil) stained sensory fibers in cultured spinal cords of the newly born opossum Monodelphis domestica [18].

Associations of Monodelphis with chemical compounds

  • Monodelphis domestica was used because it has the capacity for photoreactivation of UVR-induced pyrimidine dimers in epidermal DNA [19].
  • Plasma samples were assayed for androgen in gray short-tailed opossums (Monodelphis domestica) on the day of birth and at selected ages through adulthood [20].
  • Our immunocytochemical study suggests that in Monodelphis, puberty is reached at 4 mo, and this was further supported by a rise in circulating testosterone levels at this time [15].
  • Luteinizing hormone-releasing hormone (LHRH) was detected by immunocytochemical procedures in cells and fibers in the brain and in the nervus terminalis of the adult and neonatal gray, short-tailed opossum (Monodelphis domestica) [21].
  • We determined the time-course and general pattern of thalamocortical development of Monodelphis domestica by tracing projections with carbocyanine dye in fixed postnatal brains between postnatal day 2 (P2) and P30 [22].

Gene context of Monodelphis


Analytical, diagnostic and therapeutic context of Monodelphis


  1. The p53 tumor suppressor gene of the marsupial Monodelphis domestica: cloning of exons 4-11 and mutations in exons 5-8 in ultraviolet radiation-induced corneal sarcomas. Kusewitt, D.F., Sherburn, T.E., Miska, K.B., Tafoya, G.B., Gale, J.M., Miller, R.D. Carcinogenesis (1999) [Pubmed]
  2. Characterization of the CDKN2A and ARF genes in UV-induced melanocytic hyperplasias and melanomas of an opossum (Monodelphis domestica). Chan, J., Robinson, E.S., Atencio, J., Wang, Z., Kazianis, S., Coletta, L.D., Nairn, R.S., McCarrey, J.R. Mol. Carcinog. (2001) [Pubmed]
  3. Topical toremifene: a new approach for cutaneous melanoma? Maenpaa, J., Dooley, T., Wurz, G., VandeBerg, J., Robinson, E., Emshoff, V., Sipila, P., Wiebe, V., Day, C., DeGregorio, M. Cancer Chemother. Pharmacol. (1993) [Pubmed]
  4. Epidermal urocanic acid and suppression of contact hypersensitivity by ultraviolet radiation in Monodelphis domestica. Reeve, V.E., Ley, R.D., Reilly, W.G., Bosnic, M. Int. Arch. Allergy Immunol. (1996) [Pubmed]
  5. Photorepair of ultraviolet radiation (UVR)-induced pyrimidine dimers in lens epithelial DNA of Monodelphis domestica. Tafoya, G.B., Gale, J.M., Ley, R.D. Photochem. Photobiol. (1997) [Pubmed]
  6. The hormonal induction of mating behavior in female gray short-tailed opossums (Monodelphis domestica). Fadem, B.H., Taylor-Ali, L., Erianne, D.C. Hormones and behavior. (1996) [Pubmed]
  7. Ontogeny of cells containing estrogen receptor-like immunoreactivity in the Brazilian opossum brain. Fox, C.A., Ross, L.R., Jacobson, C.D. Brain Res. Dev. Brain Res. (1991) [Pubmed]
  8. Immunocytochemical localization of vacuolar H-ATPase in the opossum (Monodelphis domestica) kidney: comparison with the rat. Bastani, B., Yang, L., Steinhardt, G. J. Am. Soc. Nephrol. (1994) [Pubmed]
  9. Evolution of the "OR37" Subfamily of Olfactory Receptors: A Cross-Species Comparison. Hoppe, R., Lambert, T.D., Samollow, P.B., Breer, H., Strotmann, J. J. Mol. Evol. (2006) [Pubmed]
  10. Isolation of mhc class II DMA and DMB cDNA sequences in a marsupial: the gray short-tailed opossum (Monodelphis domestica). O'hUigin, C., Sültmann, H., Tichy, H., Murray, B.W. J. Mol. Evol. (1998) [Pubmed]
  11. Evolution of transthyretin gene expression in the liver of Didelphis virginiana and other American marsupials. Richardson, S.J., Wettenhall, R.E., Schreiber, G. Endocrinology (1996) [Pubmed]
  12. The effects of pheromonal stimuli on estrus and peripheral plasma estradiol in female gray short-tailed opossums (Monodelphis domestica). Fadem, B.H. Biol. Reprod. (1989) [Pubmed]
  13. Genetics of alcohol dehydrogenase and aldehyde dehydrogenase from Monodelphis domestica cornea: further evidence for identity of corneal aldehyde dehydrogenase with a major soluble protein. Holmes, R.S., van Oorschot, R.A., Vandeberg, J.L. Genet. Res. (1990) [Pubmed]
  14. Humoral immune response in a marsupial Monodelphis domestica: anti-isotypic and anti-idiotypic responses detected by species-specific monoclonal anti-immunoglobulin reagents. Shearer, M.H., Robinson, E.S., VandeBerg, J.L., Kennedy, R.C. Dev. Comp. Immunol. (1995) [Pubmed]
  15. Postnatal development of Leydig cells in the opossum (Monodelphis domestica): an immunocytochemical and endocrinological study. Xie, Q., Mackay, S., Ullmann, S.L., Gilmore, D.P., Payne, A.P., Gray, C. Biol. Reprod. (1998) [Pubmed]
  16. Chiasmatic specificity in the regenerating mammalian optic nerve. MacLaren, R.E., Taylor, J.S. Exp. Neurol. (1997) [Pubmed]
  17. Regulation of GABAB receptors by histamine and neuronal activity in the isolated spinal cord of neonatal opossum in culture. Zou, D.J., Treherne, J.M., Stewart, R.R., Saunders, N.R., Nicholls, J.G. Proc. Biol. Sci. (1991) [Pubmed]
  18. Axotomy of single fluorescent nerve fibers in developing mammalian spinal cord by photoconversion of diaminobenzidine. De-Miguel, F.F., Muller, K.J., Adams, W.B., Nicholls, J.G. J. Neurosci. Methods (2002) [Pubmed]
  19. Photoreversal of the ultraviolet radiation-induced disappearance of ATPase-positive Langerhans cells in the epidermis of Monodelphis domestica. LeVee, G.J., Applegate, L.A., Ley, R.D. J. Leukoc. Biol. (1988) [Pubmed]
  20. Evidence for high levels of androgen in peripheral plasma during postnatal development in a marsupial: the gray short-tailed opossum (Monodelphis domestica). Fadem, B.H., Harder, J.D. Biol. Reprod. (1992) [Pubmed]
  21. Immunocytochemical localization of luteinizing hormone-releasing hormone (LHRH) in the brain and nervus terminalis of the adult and early neonatal gray short-tailed opossum (Monodelphis domestica). Schwanzel-Fukuda, M., Fadem, B.H., Garcia, M.S., Pfaff, D.W. J. Comp. Neurol. (1988) [Pubmed]
  22. Development of thalamocortical projections in the South American gray short-tailed opossum (Monodelphis domestica). Molnár, Z., Knott, G.W., Blakemore, C., Saunders, N.R. J. Comp. Neurol. (1998) [Pubmed]
  23. Cross-species application of cDNA microarrays to profile gene expression using UV-induced melanoma in Monodelphis domestica as the model system. Wang, Z., Dooley, T.P., Curto, E.V., Davis, R.L., VandeBerg, J.L. Genomics (2004) [Pubmed]
  24. BDNF is expressed at the crush site after spinal cord lesion in newborn opossum (Monodelphis domestica). Vischer, H.A. Eur. J. Neurosci. (1997) [Pubmed]
  25. The prion protein gene: identifying regulatory signals using marsupial sequence. Premzl, M., Delbridge, M., Gready, J.E., Wilson, P., Johnson, M., Davis, J., Kuczek, E., Marshall Graves, J.A. Gene (2005) [Pubmed]
  26. Cloning and characterization of the CDKN2A and p19ARF genes from Monodelphis domestica. Sherburn, T.E., Gale, J.M., Ley, R.D. DNA Cell Biol. (1998) [Pubmed]
  27. Recombination activating gene-1 of the opossum Monodelphis domestica. Miller, R.D., Rosenberg, G.H. Immunogenetics (1997) [Pubmed]
  28. Olfactory bulb organization and development in Monodelphis domestica (grey short-tailed opossum). Brunjes, P.C., Jazaeri, A., Sutherland, M.J. J. Comp. Neurol. (1992) [Pubmed]
  29. Purification and characterization of fibroblast growth factors from the opossum, Monodelphis domestica, brain. Sabourin, C.L., Ley, R.D. Neurosci. Lett. (1992) [Pubmed]
  30. Ontogeny of feeding function in the gray short-tailed opossum Monodelphis domestica: empirical support for the constrained model of jaw biomechanics. Thompson, E.N., Biknevicius, A.R., German, R.Z. J. Exp. Biol. (2003) [Pubmed]
  31. The hormonal control of scent marking and precopulatory behavior in male gray short-tailed opossums (Monodelphis domestica). Fadem, B.H., Erianne, G.S., Karen, L.M. Hormones and behavior. (1989) [Pubmed]
  32. Photoreactivation of cyclobutane dimers and (6-4) photoproducts in the epidermis of the marsupial, Monodelphis domestica. Mitchell, D.L., Applegate, L.A., Nairn, R.S., Ley, R.D. Photochem. Photobiol. (1990) [Pubmed]
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