Disease relevance of Biomer

• The average surface area of the Biomer blood sacs covered with thrombus was 45 +/- 32 mm2 [1].
• Use of a semiquantitative scale to assess renal infarction demonstrated that nine of 10 animals with a surface-modifying additive copolymer blend blood sac had infarction less severe than the mean infarct score of the animals with a Biomer sac [1].
• A time-dependent phase of thrombus deposition followed by thromboembolism was observed on the PVC and Silastic shunt surfaces but not on the Biomer surface [2].
• Intraperitoneal Biomer and woven Dacron became contaminated with 100 to 10,000 enteric bacteria, including Escherichia coli, Pseudomonas aeruginosa, enterococci, and staphylococci species, within 3 days; intraperitoneal cotton and Dacron velour were contaminated within 24 hours [3].
• Giant-cell foreign-body reaction to Biomer fibrils was seen [4].

High impact information on Biomer

• The results show that the heparin release from Biomer/poly(NiPAAm)-coated surfaces resulted in a significant reduction of thrombus formation on test surfaces in contact with venous blood as compared to control surfaces [5].
• Variations between Biomer lots. 2: The effect of differences between lots on in vitro enzymatic and oxidative degradation of a commercial polyurethane [6].
• IL-1 beta secreted from human monocytes/macrophages on Biomer, polydimethylsiloxane (PDMS), Dacron, polyethylene, expanded polytetrafluoroethylene, and control polystyrene with and without the preadsorption of physiological concentrations of human IgG, fibrinogen, and/or fibronectin was assayed [7].
• The results of these studies show that Biomer and PDMS selectively activate human monocytes to produce fibroblast "progression-like" and to a lesser extent "competence-like" stimulating growth factors [8].
• To investigate the growth characteristics of endothelial cells on theoretically suitable biomaterials, we compared three polyurethanes (Pellethane, Biomer, Enka) and three silicone rubbers (Elastosil, 3145 RTV, Medical Adhesive) [9].

Biological context of Biomer

• In vivo biocompatibility studies. II. Biomer: preliminary cell adhesion and surface characterization studies [10].
• Surface analysis by attenuated total reflectance Fourier transform infrared spectroscopy indicated that the acid treatment caused hydrolysis of the polyether segments of Pellethane and Biomer [11].
• On B-PEO4K surfaces, fibrinogen adsorption kinetics demonstrated 'Vroman effect'. The Biomer and B-PEO4K grafts occluded within 1 month, while HEMA-st grafts were patent for over 3 months [12].
• For Biomer and B-PEO, occlusion times were prolonged with an increasing flow rate, while platelet count and aggregability decreased [13].
• The effect of surface integrity on the performance properties of Biomer (Ethicon, Inc, Somerville, NJ) a segmented polyurethane used in many blood contacting devices, is being investigated using uniaxial tensile tests in air at room temperature, and biaxial fatigue tests in deionized water at body temperature [14].

Anatomical context of Biomer

• In vivo biocompatibility studies. V. In vivo leukocyte interactions with Biomer [15].
• The differential analysis revealed that macrophages preferentially adhered to the Biomer surface compared to other leukocytes in the exudate [15].
• Supernatants obtained from monocytes cultured in the presence of Biomer, a segmented polyetherurethane, were unable to stimulate fibroblast proliferation [16].
• Scanning electron microscopy (SEM) in conjunction with cytochemical staining procedures were used to investigate the cellular events at the leukocyte/Biomer interface as well as in the inflammatory exudate over a 21-day implantation period [15].
• Biomer grafts were more viscous than canine carotid and femoral arteries, especially at the higher frequencies [17].

Associations of Biomer with other chemical compounds

• Polydimethylsiloxane stimulated the monocytes/macrophages to produce more "progression-like" fibro-blast stimulating growth factors than Biomer [8].
• In vitro platelet adhesion and release reactions from rabbit platelet-rich plasma were shown to be greatest on Biomer and PS homopolymer surfaces and least on cross-linked PEO surfaces, with the PEO-PS block copolymers demonstrating intermediate responses [18].
• Effect of toluene extraction on Biomer surface: II. An atomic force microscopy study [19].
• The Ka was higher for M1 binding to fibrinogen adsorbed to Immulon I than to Biomer, Biospan or poly(ethylene terephthalate), suggesting that fibrinogen adsorbed to Immulon I is more platelet adhesive than fibrinogen adsorbed to the other polymers [20].
• The performance of a new compliant microfibrous polyetherurethane urea (Biomer) synthetic artery of our design has been studied in a series of 26 consecutive implants as carotid artery replacements in dogs [21].

Gene context of Biomer

• Statistically significant differences in IL1 production were observed between polymers, allowing their classification according to reactivity into high (Dacron, PE), intermediate (ePTFE) and low (Biomer, PDMS) reactive groups [22].
• Effect of toluene extraction on Biomer surface: I. ESCA, ATR/FTIR, contact angle analysis and biological properties [23].
• VAD Biomer blood sacs: mechanical tests and ultrastructural observations [24].

Analytical, diagnostic and therapeutic context of Biomer

• In four control implants the blood sacs and cannulas were fabricated from Ethicon's Biomer segmented polyurethane, which is the present clinical standard for most artificial hearts and circulatory support devices [1].
• Previous workers have used FTIR and ESCA to study Biomer and comparisons with their results will be discussed [25].
• These results indicate that Biomer and Toyobo TM5 are more suitable for flexible components of cardiac prostheses [26].
• Cast Biomer films were characterized by weight, advancing contact angle with water in air, attenuated total reflectance infrared spectroscopy and scanning electron microscopy (SEM) [27].
• A method of evaluating the in vitro viscoelastic properties of microfibrous Biomer poly(ether-urethane-urea) vascular prostheses is outlined [17].

References