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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of PubMed

  • We searched the National Library of Medicine PubMed database as well as references of retrieved articles and summarized the current evidence for the use of FFP and platelet transfusions in critically ill patients [1].
  • This review has taken in consideration papers published after 1995 and available on PubMed medline: the data indicate a potential usefulness of ifosfamide in the clinical management of advanced breast cancer, even if the exact therapeutic role of the drug in this setting should be derived from randomized studies not yet available [2].
  • In this review article we searched the National Library of Medicine PubMed database as well as references of retrieved articles and summarized the methods for differentiating between hydrostatic and permeability pulmonary edema [3].
  • MATERIALS AND METHODS: A comprehensive literature review of manuscripts published on AR in prostate cancer was performed using PubMed [4].
  • METHODS: The key terms, adult onset Still's disease, AOSD, adult Still's disease, ASD, Still's disease were used to search Medline (1966-2005) and PubMed (1966-2005) for all available articles in the English language [5].

Psychiatry related information on PubMed

  • METHODS: Using the PubMed service of the National Library of Medicine, all English language articles published in 2000, 2001 and the first half of 2002 with a key word of 'dementia' were reviewed for articles that described the emerging pathophysiologic model for Alzheimer disease [6].

High impact information on PubMed

  • A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50,000 articles providing one or the other information about this pleiotropic cytokine or its relatives [7].
  • METHODS: A PubMed search was performed on CEA, along with various qualifiers such as cancer vaccines, epitopes, and function [8].
  • FCP ( a bioinformatic tool assisting in PubMed searches for literature on fibrosis-related cytokines [9].
  • METHODS: Electronic searches of the MEDLINE (PubMed) database, Cochrane Library, EMBase, and Science Citation Index were performed [10].
  • METHODS: Systematic literature review of all PubMed citations between 1999 and August 2003 focusing on clinically relevant biochemical and physiological characteristics of ghrelin [11].

Chemical compound and disease context of PubMed


Biological context of PubMed


Anatomical context of PubMed


Associations of PubMed with chemical compounds

  • EVIDENCE ACQUISITION: A PubMed search was conducted for relevant most recent findings in both humans and animals in the context of an intriguing observation of ongoing periosteal expansion after estrogen treatment in an aromatase-deficient boy [25].
  • DATA SOURCES: The search term modafinil OR Provigil was searched on PubMed [26].
  • We performed several PubMed searches of the National Library of Medicine for articles in English about artificial sweeteners [27].
  • We searched Pubmed, Embase, PsychInfo, Biosis, and Digital Dissertations (January 1966-June 2003) and included 45 parallel-group (young vs. old subjects) studies that used either a pharmacological or psychological challenge in healthy volunteers and measured cortisol response to challenge [28].
  • A PubMed database search and other methods identified 14 vitamin A, 21 iron, and 5 multimicronutrient intervention studies that met the design criteria [29].

Gene context of PubMed

  • Over the period from 2000 through 2003, PubMed searches with the key word CYP2C8 returned only 10% to 15% of the citations obtained for all of the CYP2C enzymes combined [30].
  • METHODS: Several comprehensive Pubmed searches for the period January 1993 to May 2005 were performed using strategic combinations of the terms non-small cell lung cancer, angiogenesis, vascular endothelial growth factor, basic fibroblast growth factor, tumour expression, microvessel density, circulating, and serum [31].
  • METHOD: Using the search term ADHD, a selective PubMed review of the clinical literature was undertaken to evaluate recent data relevant to ADHD with attention to a life span perspective of the disorder [32].
  • We conducted a PubMed literature search of BPPV case series which specified the affected side and a retrospective chart review of 80 consecutive patients with BPPV of the posterior canal who had presented at our dizziness clinic.Eighteen studies with a total of 3426 patients were identified [33].
  • This article examines the relationship between EGFR expression and cancer prognosis based on literature compiled on PubMed between 1985 and September 2000 [34].

Analytical, diagnostic and therapeutic context of PubMed


  1. Fresh frozen plasma and platelet transfusion for nonbleeding patients in the intensive care unit: benefit or harm? Gajic, O., Dzik, W.H., Toy, P. Crit. Care Med. (2006) [Pubmed]
  2. Ifosfamide in advanced/disseminated breast cancer. Sorio, R., Lombardi, D., Spazzapan, S., La Mura, N., Tabaro, G., Veronesi, A. Oncology (2003) [Pubmed]
  3. Pulmonary edema after transfusion: how to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury. Gajic, O., Gropper, M.A., Hubmayr, R.D. Crit. Care Med. (2006) [Pubmed]
  4. Androgen receptors in prostate cancer. Culig, Z., Klocker, H., Bartsch, G., Steiner, H., Hobisch, A. J. Urol. (2003) [Pubmed]
  5. Diagnosis and management of adult onset Still's disease. Efthimiou, P., Paik, P.K., Bielory, L. Ann. Rheum. Dis. (2006) [Pubmed]
  6. Managing Alzheimer dementia tomorrow. Rosenthal, T.C., Khotianov, N. The Journal of the American Board of Family Practice / American Board of Family Practice. (2003) [Pubmed]
  7. Tumor necrosis factor signaling. Wajant, H., Pfizenmaier, K., Scheurich, P. Cell Death Differ. (2003) [Pubmed]
  8. Carcinoembryonic antigen as a target for therapeutic anticancer vaccines: a review. Berinstein, N.L. J. Clin. Oncol. (2002) [Pubmed]
  9. FCP ( a bioinformatic tool assisting in PubMed searches for literature on fibrosis-related cytokines. Atamas, S.P. Arthritis Rheum. (2003) [Pubmed]
  10. Systematic review of surgical options for idiopathic megarectum and megacolon. Gladman, M.A., Scott, S.M., Lunniss, P.J., Williams, N.S. Ann. Surg. (2005) [Pubmed]
  11. Ghrelin: integrative neuroendocrine peptide in health and disease. Wu, J.T., Kral, J.G. Ann. Surg. (2004) [Pubmed]
  12. Role of aztreonam in the treatment of nosocomial pneumonia in the critically ill surgical patient. Boucher, B.A. Am. J. Surg. (2000) [Pubmed]
  13. Treatment of hypertension with an angiotensin II-receptor antagonist compared with an angiotensin-converting enzyme inhibitor: a review of clinical studies of telmisartan and enalapril. Smith, D.H. Clinical therapeutics. (2002) [Pubmed]
  14. Meta-analysis on the effect of off-pump coronary bypass surgery. van der Heijden, G.J., Nathoe, H.M., Jansen, E.W., Grobbee, D.E. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2004) [Pubmed]
  15. Cyclophosphamide in lupus nephritis. Houssiau, F.A. Lupus (2005) [Pubmed]
  16. A review of entecavir in the treatment of chronic hepatitis B infection. Rivkin, A. Current medical research and opinion. (2005) [Pubmed]
  17. Atypical antipsychotics and glucose homeostasis. Bergman, R.N., Ader, M. The Journal of clinical psychiatry. (2005) [Pubmed]
  18. Intestinal permeability and systemic infections in critically ill patients: effect of glutamine. De-Souza, D.A., Greene, L.J. Crit. Care Med. (2005) [Pubmed]
  19. Epidemiology of complementary alternative medicine for asthma and allergy in Europe and Germany. Schäfer, T. Ann. Allergy Asthma Immunol. (2004) [Pubmed]
  20. Angiotensin-converting enzyme gene and diabetes mellitus. Kennon, B., Petrie, J.R., Small, M., Connell, J.M. Diabet. Med. (1999) [Pubmed]
  21. Bibliometric analysis of global trends for research productivity in microbiology. Vergidis, P.I., Karavasiou, A.I., Paraschakis, K., Bliziotis, I.A., Falagas, M.E. Eur. J. Clin. Microbiol. Infect. Dis. (2005) [Pubmed]
  22. Clinical utilization of atypical antipsychotics in pregnancy and lactation. Gentile, S. The Annals of pharmacotherapy. (2004) [Pubmed]
  23. Granulocyte colony-stimulating factor-induced capillary leak syndrome confirmed by extravascular lung water measurements. Deeren, D.H., Zachee, P., Malbrain, M.L. Ann. Hematol. (2005) [Pubmed]
  24. What is the best postoperative treatment for patients with pT3bN0M0 adenocarcinoma of the prostate? Kasibhatla, M., Peterson, B., Anscher, M.S. Prostate Cancer Prostatic Dis. (2005) [Pubmed]
  25. Clinical Review: Sex steroids and the periosteum--reconsidering the roles of androgens and estrogens in periosteal expansion. Vanderschueren, D., Venken, K., Ophoff, J., Bouillon, R., Boonen, S. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  26. A systematic review of modafinil: potential clinical uses and mechanisms of action. Ballon, J.S., Feifel, D. The Journal of clinical psychiatry. (2006) [Pubmed]
  27. Artificial sweeteners--do they bear a carcinogenic risk? Weihrauch, M.R., Diehl, V. Ann. Oncol. (2004) [Pubmed]
  28. A meta-analysis of cortisol response to challenge in human aging: importance of gender. Otte, C., Hart, S., Neylan, T.C., Marmar, C.R., Yaffe, K., Mohr, D.C. Psychoneuroendocrinology (2005) [Pubmed]
  29. Multimicronutrient interventions but not vitamin a or iron interventions alone improve child growth: results of 3 meta-analyses. Ramakrishnan, U., Aburto, N., McCabe, G., Martorell, R. J. Nutr. (2004) [Pubmed]
  30. Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance. Totah, R.A., Rettie, A.E. Clin. Pharmacol. Ther. (2005) [Pubmed]
  31. Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood. Bremnes, R.M., Camps, C., Sirera, R. Lung Cancer (2006) [Pubmed]
  32. A clinical perspective of attention-deficit/hyperactivity disorder into adulthood. Wilens, T.E., Dodson, W. The Journal of clinical psychiatry. (2004) [Pubmed]
  33. Benign paroxysmal positional vertigo predominantly affects the right labyrinth. von Brevern, M., Seelig, T., Neuhauser, H., Lempert, T. J. Neurol. Neurosurg. Psychiatr. (2004) [Pubmed]
  34. EGFR and cancer prognosis. Nicholson, R.I., Gee, J.M., Harper, M.E. Eur. J. Cancer (2001) [Pubmed]
  35. Protein C/activated protein C pathway: overview of clinical trial results in severe sepsis. Dhainaut, J.F., Yan, S.B., Claessens, Y.E. Crit. Care Med. (2004) [Pubmed]
  36. Maternal exposure to caffeine and risk of congenital anomalies: a systematic review. Browne, M.L. Epidemiology (Cambridge, Mass.) (2006) [Pubmed]
  37. Case reports and case series from Lancet had significant impact on medical literature. Albrecht, J., Meves, A., Bigby, M. Journal of clinical epidemiology. (2005) [Pubmed]
  38. Calcium channel blockers for reducing cardiac morbidity after noncardiac surgery: a meta-analysis. Wijeysundera, D.N., Beattie, W.S. Anesth. Analg. (2003) [Pubmed]
  39. Worldwide research productivity in critical care medicine. Michalopoulos, A., Bliziotis, I.A., Rizos, M., Falagas, M.E. Critical care (London, England) (2005) [Pubmed]
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