Disease relevance of [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury

• Mercury poisoning from mercurochrome therapy of infected omphalocele [1].
• This hypersensitivity was inducible by prior exposure to low, subtoxic Hg2+ or merbromin levels [2].
• Two patients had an anaphylactic reaction a few minutes after application of Mercurochrome [3].
• Mercurochrome allergy. Immediate and delayed hypersensitivity [3].
• In the other six patients, the clinical picture was local eczema, and the patch tests were all positive with Mercurochrome and the inorganic mercuric derivatives [3].

High impact information on [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury

• PSHr and TRPS were stained using 2,2'-dihydroxy-6,6'-dinaphthyl disulfide; PSHt and PDS were stained using mercurochrome methods [4].
• Furthermore, resistance to thimerosal, merbromin, and methylmercury and the ability to volatilize 14C from [14C]methylmercury were found with the new isolates and never with previously known mercurial resistance plasmids in S. aureus [5].
• Interaction of aspartate aminotransferase with mercurochrome. Relationship of an exposed thiol group of the enzyme to the active centre [6].
• When both fragments were cloned together into a derivative of plasmid ColE1, the hybrid plasmid conferred properties indistinguishable from those of the parental plasmid, NR1: resistance to Hg2+ and to the organomercurials merbromin and fluoresceinmercuric acetate and the inducible synthesis of the enzyme mercuric reductase [2].
• Systemic allergic reactions to mercury are most commonly provoked by the inhalation of metallic mercury vapours from a broken thermometer, often after previous sensitization to mercury compounds, e.g. Mercurochrome [7].

Chemical compound and disease context of [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury

• By the use of intradermal tests, passive transfer (P.K.), and an in vitro histamine release test, we were able to demonstrate immediate hypersensitivity to Mercurochrome in a young man who had suffered anaphylactic shock after having contact with this antiseptic [8].
• Resistance determinants for HgCl2 and CdCl2 were eliminated along with a number of antibiotic resistance factors from Acinetobacter lwoffi and Micrococcus sp. at 44 degrees C. These organisms were orginally resistant to HgCl2, merbromin, CdCl2, Pb(NO3)2, benzylpenicillin, erythromycin, carbenicillin, tetracycline and sulfadiazine [9].

Biological context of [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury

• The effects of the topical antiseptic agents mercurochrome and silver nitrate and of sodium hyaluronate on the process of wound healing were assessed by macroscopic examination, light microscopy histology, electron microscopy and scanning electron microscopy of wounds made by cutting or by abrasion of the skin of rats [10].

Anatomical context of [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury

• A 30-cm umbilical cord filled with mercurochrome, hung inside the container, was the target for the puncture [11].
• It consists of filtering urine samples through Nytrel filters followed by mercurochrome staining to assist in the detection of viable (motile) miracidia in egg shells, and iodine staining to show hatched miracidia [12].
• In forty cases mercurochrome was applied as the antifungal agent after cleaning the external auditory canal, in twenty-three clotrimazole and in rest of the seventeen patients miconazole was used [13].

Associations of [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury with other chemical compounds

• This article reviews such non-conventional topical therapies as aloe vera, antacids, benzoyl peroxide, collagen, dilantin, gentian violet, impregnated gauzes, insulin, mercurochrome, oxygen therapy, sugar, and vinegar [14].

Gene context of [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury

• Omphalocele is a disease of neonatal age and its present management is successful in almost all specialized centers of Pediatric Surgery. A case of an 8-year-old girl who was managed with conservative treatment during her neonatal period with mercurochrome (Grob method) is presented [15].

Analytical, diagnostic and therapeutic context of [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury

• To localize compounds containing sulphydryl groups, fresh or fixed frozen sections of the plants were treated with mercurochrome [16].
• Mercurochrome was applied to tissues and tissue sections in an attempt to examine structural components either in visible light, fluorescence or electron microscopy [17].
• We report that the electrical diode characteristics of the TiO(2)/Au Schottky barrier deteriorate by deposition of a hydrophobic quantum dot film, Merbromin dye adsorption, or electron-hole photogeneration in TiO(2) under inert conditions [18].
• Childhood vaccinations, merbromin used as an antiseptic, broken thermometers, and the use of drops were the main sources of exposure [19].
• After treatment with mercurochrome in acetone before embedding, the eosinophilic granules from leucocytes and chromatin masses showed electron opacity as well as a yellowish green fluorescence under excitation with violet-blue or blue light [17].

References