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Chemical Compound Review

merbromin     disodium [2,7-dibromo-9-(2...

Synonyms: M7011_SIGMA, CCG-39726, HMS501E17, AKOS015903744, HMS1921M15, ...
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Disease relevance of [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury


High impact information on [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury


Chemical compound and disease context of [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury


Biological context of [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury


Anatomical context of [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury


Associations of [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury with other chemical compounds


Gene context of [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury

  • Omphalocele is a disease of neonatal age and its present management is successful in almost all specialized centers of Pediatric Surgery. A case of an 8-year-old girl who was managed with conservative treatment during her neonatal period with mercurochrome (Grob method) is presented [15].

Analytical, diagnostic and therapeutic context of [2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxo-xanthen-4-yl]mercury

  • To localize compounds containing sulphydryl groups, fresh or fixed frozen sections of the plants were treated with mercurochrome [16].
  • Mercurochrome was applied to tissues and tissue sections in an attempt to examine structural components either in visible light, fluorescence or electron microscopy [17].
  • We report that the electrical diode characteristics of the TiO(2)/Au Schottky barrier deteriorate by deposition of a hydrophobic quantum dot film, Merbromin dye adsorption, or electron-hole photogeneration in TiO(2) under inert conditions [18].
  • Childhood vaccinations, merbromin used as an antiseptic, broken thermometers, and the use of drops were the main sources of exposure [19].
  • After treatment with mercurochrome in acetone before embedding, the eosinophilic granules from leucocytes and chromatin masses showed electron opacity as well as a yellowish green fluorescence under excitation with violet-blue or blue light [17].


  1. Mercury poisoning from mercurochrome therapy of infected omphalocele. Yeh, T.F., Pildes, R.S., Firor, H.V., Szanto, P.B. Lancet (1978) [Pubmed]
  2. Hypersensitivity to Hg2+ and hyperbinding activity associated with cloned fragments of the mercurial resistance operon of plasmid NR1. Nakahara, H., Silver, S., Miki, T., Rownd, R.H. J. Bacteriol. (1979) [Pubmed]
  3. Mercurochrome allergy. Immediate and delayed hypersensitivity. Galindo, P.A., Feo, F., García, R., Gómez, E., Borja, J., Fernández, F. Allergy (1997) [Pubmed]
  4. Quantitative measurements of the changes in protein thiols in cervical intraepithelial neoplasia and in carcinoma of the human uterine cervix provide evidence for the existence of a biochemical field effect. Benedetto, C., Bajardi, F., Ghiringhello, B., Marozio, L., Nöhammer, G., Phitakpraiwan, P., Rojanapo, W., Schauenstein, E., Slater, T.F. Cancer Res. (1990) [Pubmed]
  5. Selection for mercurial resistance in hospital settings. Porter, F.D., Silver, S., Ong, C., Nakahara, H. Antimicrob. Agents Chemother. (1982) [Pubmed]
  6. Interaction of aspartate aminotransferase with mercurochrome. Relationship of an exposed thiol group of the enzyme to the active centre. Kalogerakos, T.G., Oikonomakos, N.G., Dimitropoulos, C.G., Karni-katsadima, I.A., Evangelopoulos, A.E. Biochem. J. (1977) [Pubmed]
  7. Systemically induced allergic exanthem from mercury. Lerch, M., Bircher, A.J. Contact Derm. (2004) [Pubmed]
  8. Anaphylactic hypersensitivity to mercurochrome (merbrominum). Corrales Torres, J.L., De Corres, F. Annals of allergy. (1985) [Pubmed]
  9. Elimination of mercury, cadmium and antibiotic resistance from Acinetobacter lwoffi and Micrococcus sp. at high temperature. Bhattacharyya, G., Chaudhuri, J., Mandal, A. Folia Microbiol. (Praha) (1988) [Pubmed]
  10. Topical treatment of experimental skin lesions in rats: macroscopic, microscopic and scanning electron-microscopic evaluation of the healing process. Trabucchi, E., Preis Baruffaldi, F., Baratti, C., Montorsi, W. International journal of tissue reactions. (1986) [Pubmed]
  11. Experience of the first 50 cases of cordocentesis after training with model. Tongprasert, F., Tongsong, T., Wanapirak, C., Sirichotiyakul, S., Piyamongkol, W., Chanprapaph, P. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. (2005) [Pubmed]
  12. Egg viability in urinary schistosomiasis. I. New methods compared with available methods. Braun-Munzinger, R.A., Southgate, B.A. The Journal of tropical medicine and hygiene. (1993) [Pubmed]
  13. Otomycosis--a clinico-mycological study and efficacy of mercurochrome in its treatment. Chander, J., Maini, S., Subrahmanyan, S., Handa, A. Mycopathologia (1996) [Pubmed]
  14. Non-conventional topical therapies for wound care. Rund, C.R. Ostomy/wound management. (1996) [Pubmed]
  15. Management of neglected giant omphalocele with Gore-tex in a child aged 8 years. Sakellaris, G., Petrakis, I., Vlazakis, S., Kakavelakis, K., Vasiliou, M., Antipas, S., Ntolatzas, T. Minerva Pediatr. (2002) [Pubmed]
  16. Two rapid fluorescence procedures for the detection of some thio pungent compounds in plant tissues. Bruni, A., Dall'olio, G. Histochem. J. (1980) [Pubmed]
  17. Mercurochrome: a fluorescent and electron opaque dye. Ferrer, J.M., González Garrigues, M., Stockert, J.C. Microscopica acta. (1983) [Pubmed]
  18. Chemisorption Determines the Photovoltage of a Ti/TiO(2)/Au/Dye Internal Electron Emission Photovoltaic Cell. Koole, R., Liljeroth, P., Oosterhout, S., Vanmaekelbergh, D. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
  19. Allergic contact dermatitis from mercury antiseptics and derivatives: study protocol of tolerance to intramuscular injections of thimerosal. Audicana, M.T., Muñoz, D., del Pozo, M.D., Fernández, E., Gastaminza, G., Fernández de Corres, L. Am. J. Contact Dermatitis (2002) [Pubmed]
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