Disease relevance of Truncus Arteriosus

• In eight infants and children with either pulmonary atresia and a ventricular septal defect or truncus arteriosus communis, excellent visualization was consistently achieved without complication [1].
• Echo-phonocardiographic and contrast studies in conditions associated with systemic arterial trunk overriding the ventricular septum: truncus arteriosus, tetralogy of Fallot, and pulmonary atresia with ventricular septal defect [2].
• Diagnoses of coarctation of the aorta, Ebstein's anomaly, atrial septal defect, and truncus arteriosus are overrepresented in infants found by community search, particularly in those infants without associated malformations [3].
• The proband in family 1 was a male infant with persistent hypocalcemia and cardiac defects consisting of truncus arteriosus, atrial septal defect, ventricular septal defect, and abnormal aortic arch vessels [4].
• The diagnosis was pulmonary atresia in eight patients, truncus arteriosus in seven, and transposition of the great arteries with ventricular septal defect and pulmonary stenosis in three [5].

High impact information on Truncus Arteriosus

• Mortality rates for coarctation, ventricular septal defect, atrioventricular septal defect, Fallot, and truncus arteriosus operations were 1.1%, 0.6%, 3.6%, 2.3%, and 28.6%, respectively [6].
• We studied 55 fetal rats with truncus arteriosus among 300 fetuses from 40 virgin females treated with 200 mg fertilysin on the 10th day of pregnancy [7].
• 5. During gastrulation, the transcripts are expressed in the forming mesoderm and later during development cripto gene expression is restricted to the truncus arteriosus of the developing heart [8].
• Mox-1 signal is also prominent over the mesenchyme of the heart cushions and truncus arteriosus, which arises from epithelial-mesenchymal transformation and over a limited number of craniofacial foci of neural crest-derived mesenchyme that are associated with muscle attachment sites [9].
• Cardiac PP2A alpha expression was regionally restricted to the atrium, ventricle, and truncus arteriosus [10].

Chemical compound and disease context of Truncus Arteriosus

• Tetralogy of Fallot, truncus arteriosus, abnormal myocardial architecture and anomalies of the aortic arch system induced by bis-diamine in rat fetuses [11].

Biological context of Truncus Arteriosus

• Abnormal fetal sonographic findings included small for gestational age, a ventricular septal defect, and truncus arteriosus [12].
• The septation of the truncus arteriosus and the development of the aortic arch-derived blood vessels was studied in homozygotes of the Splotch mutant allele Sp1H [13].
• In particular, there is a greater incidence of coarctation of the aorta, double-inlet left ventricle, hypoplastic left heart, truncus arteriosus, double-outlet right ventricle, and atrioventricular septal defect among stillbirths [14].

Anatomical context of Truncus Arteriosus

• These findings are consistent with the possibility that a subset of Wnt-1 expressing cells include neural crest cells known to contribute to septation of the truncus arteriosus and to formation of the visceral arches [15].
• Surgical correction of truncus arteriosus requires the creation of right ventricular to pulmonary artery continuity and closure of the ventricular septal defect [16].
• Truncus arteriosus communis associated with mitral valve and left ventricular hypoplasia without ventricular septal defect: unique combination [17].
• The appearance and distribution of desmin, a muscle type intermediate filament, was examined in the truncus arteriosus of the chick embryonic heart during AP septation by an indirect immunofluorescence method [18].

Associations of Truncus Arteriosus with chemical compounds

• Transverse imaging sections at the base of the heart facilitated identification of the pulmonary artery origin of truncus arteriosus type I. Subcostal coronal and sagittal views imaged the common truncus and the ventricular septal defect [19].
• An aborted human fetus with truncus arteriosus communis--possible teratogenic effect of Tedral [20].
• Slow descent of the heart in retinoid-exposed embryos enables the "wrong" crest cell population to populate the wall of the truncus arteriosus [21].

Gene context of Truncus Arteriosus

• During gastrulation in the mouse, cripto-encoding transcripts are expressed in the forming mesoderm and later in the truncus arteriosus of the developing heart [22].
• Wnt-11 expression is first detected within the truncus arteriosus from 8.25 dpc [23].
• During the early stages of mouse gastrulation, cripto mRNA is detected in mesodermal cells; later, cripto mRNA is detected only in the truncus arteriosus of the developing heart [24].
• Truncus arteriosus with total anomalous pulmonary venous return and interrupted arch [25].
• Immunohistochemistry established the localization of vitronectin in the myocardial cells and in some of the cushion mesenchymal cells of the truncus arteriosus and atrioventricular canal [26].

References