Disease relevance of Ebstein's Anomaly

• The search terms were lithium, pregnancy, teratogen, abnormalities (drug induced), Ebstein's anomaly, and adverse effects [1].
• Five patients had associated cardiac abnormalities, including atrial septal defect, aortic insufficiency, mitral valve prolapse, Ebstein's anomaly, and cardiomyopathy [2].
• Cardiac anomalies were detected in 16 (89%) children: Left ventricular hypertrophy in eight, pulmonary stenosis in six, discrete subaortic stenosis in two, and Ebstein anomaly and ventricular septal defect in one each [3].
• We describe the contribution of 2-dimensional colour-coded Doppler echocardiography to identifying, in a 15-year-old girl a clinically mild Ebstein's anomaly with associated ventricular septal defect (VSD) which, by pulsed-Doppler, was misinterpreted as Ebstein's anomaly with tricuspid regurgitation [4].
• Lithium exposure during the first trimester seems to increase the risk of congenital heart disease, especially Ebstein's anomaly [5].

Psychiatry related information on Ebstein's Anomaly

• Six patients had associated diseases: Ebstein's anomaly in 4, epilepsy in 1 and mental retardation with scoliosis in 1 [6].

High impact information on Ebstein's Anomaly

• DATA EXTRACTION AND SYNTHESIS--In the 1970s a very strong association was suggested between maternal lithium treatment during pregnancy and Ebstein's anomaly of the heart in the offspring [1].
• METHODS: Since 1996, this procedure has been performed in 5 patients in New York Heart Association functional class IV: 2 adults with arrhythmogenic right ventricular dysplasia and 3 children with Ebstein anomaly [7].
• The technique is illustrated in the successful implantation of an atrial lead in a patient with Ebstein's anomaly characterized by a severely dilated right atrium and extremely low-amplitude voltage signals, requiring a DDD pacemaker [8].
• Usefulness of prolonged prostaglandin infusion in neonates with Ebstein's anomaly [9].
• Since 1990, radiofrequency ablation of accessory atrioventricular (AV) pathways has been attempted in 10 patients (age range 3.5 months to 30 years) with congenital heart disease: Ebstein's anomaly (n = 5), heterotaxy with AV discordance (n = 3), tetralogy of Fallot (n = 1) and total anomalous pulmonary venous return (n = 1) [10].

Chemical compound and disease context of Ebstein's Anomaly

• Transient platypnea-orthodeoxia-like syndrome induced by propafenone overdose in a young woman with Ebstein's anomaly [11].
• Successful prenatal digoxin therapy for Ebstein's anomaly with hydrops fetalis. A case report [12].
• A diagnosis of Ebstein anomaly was made, and intravenous PGE1 was started to keep patent the ductus arteriosus [13].
• We describe a critically ill neonate with morphologically mild Ebstein's anomaly who was successfully managed with intensive care including isoproterenol administration for functional pulmonary atresia [14].
• Formalin infiltration of the ductus arteriosus was performed in 13 neonates with pulmonary atresia (three with ventricular septal defect, two with tricuspid atresia, and eight with intact ventricular septum, one of whom had Ebstein's anomaly) in an attempt to maintain duct patency [15].

Biological context of Ebstein's Anomaly

• Definitive operation (tricuspid valvuloplasty or replacement and atrial septal defect closure) for Ebstein's anomaly results in significant improvement of exercise tolerance, normalization of systemic arterial oxygen saturation and reduction of excess ventilation at rest and during exercise [16].

Anatomical context of Ebstein's Anomaly

• Ebstein's anomaly is a rare congenital malformation of the tricuspid valve, often associated with an atrial septal defect [17].
• Associated abnormalities included Ebstein's anomaly (12%), other arrhythmias (34%), coronary artery disease (6%), cardiomyopathy (6%), and congenital heart disease other than Ebstein's anomaly (22%) [18].
• Rapid two-stage repair of S,L,L, ventricular septal defect, pulmonary atresia, Ebstein anomaly of the tricuspid valve, and stenotic pulmonary arteries [19].

Gene context of Ebstein's Anomaly

• Other cardiac problems were frequently present, such as hypertrophic cardiomyopathy and Ebstein's anomaly [20].
• The defect of the right ventricular free wall was covered with a polytetrafluoroethylene patch in the 2 patients with arrhythmogenic right ventricular dysplasia and directly closed with the remnant of the free wall in the 3 children with Ebstein anomaly [7].
• In this study we describe a 15-year-old boy with Ebstein anomaly, atrial septal defect (ASD), atrioventricular (AV) conduction defect, and microcephaly [21].
• Ebstein's anomaly and gastroesophageal reflux [22].
• Common atrium with Ebstein's anomaly in a neonate with Ellis-van Creveld syndrome [23].

Analytical, diagnostic and therapeutic context of Ebstein's Anomaly

• Maternal lithium and neonatal Ebstein's anomaly: evaluation with cross-sectional echocardiography [24].
• Radiofrequency catheter ablation seems to be useful for supraventricular tachycardia in patients with Ebstein's anomaly and atrial septal defect [25].

References