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Chemical Compound Review

Snowfine     trisodium hydroxymethanoate carbonate

Synonyms: Carbicarb, Urao, Magadi soda, HSDB 769, AC1L1VYB, ...
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Disease relevance of carbonic acid


High impact information on carbonic acid


Chemical compound and disease context of carbonic acid


Biological context of carbonic acid


Anatomical context of carbonic acid


Associations of carbonic acid with other chemical compounds

  • After therapy, the arterial pH rose with carbicarb (7.22 to 7.27, p less than .01), and fell with NaHCO3 (7.18 to 7.13, p less than .01) [2].
  • Systemic utilization of lactate increased from 0.3 +/- 1.0 mmol/min (baseline) to 5.6 +/- 4.3 mmol/min (45 mins after treatment) in Carbicarb-treated patients, and increased from 1.0 +/- 0.6 mmol/min (baseline) to 1.5 +/- 1.3 mmol/min in the sodium bicarbonate-treated patients, p = .033 (between groups) [4].
  • Urine composition was not affected by sodium sesquicarbonate, but urine pH (8.14 vs. 8.04) and total urine output as estimated by creatinine concentration were higher than that of controls [9].
  • Effect of Magadi soda treatment on the tannin content and in-vitro nutritive value of grain sorghums [13].

Gene context of carbonic acid

  • INTERVENTIONS: Patients were randomly assigned to receive either sodium bicarbonate (1 mEq sodium/mL, n = 18) or 1 mol Carbicarb (1 mEq sodium/mL, n = 18) administered by intravenous bolus over a 30-sec period [4].

Analytical, diagnostic and therapeutic context of carbonic acid

  • Comparison of sodium bicarbonate, Carbicarb, and THAM during cardiopulmonary resuscitation in dogs [14].
  • RESULTS: As compared to the NaCl and the time control groups, the administration of carbicarb led to significant alkalinization of the ECF, pH rose from 7.23 +/- 0.02 to 7.34 +/- 0.03 [15].
  • Immersion of corroded copper artefacts in dilute sodium sesquicarbonate solution is a well-recognized stabilization technique-especially in the conservation of objects recovered from marine environments and therefore saturated with chlorides [16].


  1. Buffer solutions may compromise cardiac resuscitation by reducing coronary perfusion presssure. Kette, F., Weil, M.H., Gazmuri, R.J. JAMA (1991) [Pubmed]
  2. Improved hemodynamic function during hypoxia with Carbicarb, a new agent for the management of acidosis. Bersin, R.M., Arieff, A.I. Circulation (1988) [Pubmed]
  3. Effects of acid-base correction on hemodynamics, oxygen dynamics, and resuscitability in severe canine hemorrhagic shock. Benjamin, E., Oropello, J.M., Abalos, A.M., Hannon, E.M., Wang, J.K., Fischer, E., Iberti, T.J. Crit. Care Med. (1994) [Pubmed]
  4. Safety and efficacy of intravenous Carbicarb in patients undergoing surgery: comparison with sodium bicarbonate in the treatment of mild metabolic acidosis. SPI Research Group. Study of Perioperative Ischemia. Leung, J.M., Landow, L., Franks, M., Soja-Strzepa, D., Heard, S.O., Arieff, A.I., Mangano, D.T. Crit. Care Med. (1994) [Pubmed]
  5. Effects of buffer agents on postresuscitation myocardial dysfunction. Sun, S., Weil, M.H., Tang, W., Fukui, M. Crit. Care Med. (1996) [Pubmed]
  6. Correction of metabolic acidosis in experimental CPR: a comparative study of sodium bicarbonate, carbicarb, and dextrose. Blecic, S., De Backer, D., Deleuze, M., Vachiery, J.L., Vincent, J.L. Annals of emergency medicine. (1991) [Pubmed]
  7. Low-dose Carbicarb improves cerebral outcome after asphyxial cardiac arrest in rats. Katz, L.M., Wang, Y., Rockoff, S., Bouldin, T.W. Annals of emergency medicine. (2002) [Pubmed]
  8. Hemodynamic and hepatic pH responses to sodium bicarbonate and Carbicarb during systemic acidosis. Shapiro, J.I., Whalen, M., Chan, L. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1990) [Pubmed]
  9. Sodium sesquicarbonate for early lactation dairy cows fed corn silage-based diets. Cassida, K.A., Muller, L.D., Sweeney, T.F. J. Dairy Sci. (1988) [Pubmed]
  10. Natural sodium sesquicarbonate fed for an entire lactation: influence on performance and acid-base status of dairy cows. Tucker, W.B., Shin, I.S., Hogue, J.F., Aslam, M., Adams, G.D., Van Koevering, M.T., Vernon, R.K., Cummings, K.R. J. Dairy Sci. (1994) [Pubmed]
  11. The nutritive value for rats of high- and low-tannin sorghums treated with magadi soda. Muindi, P.J., Thomke, S. J. Sci. Food Agric. (1981) [Pubmed]
  12. The effects of sodium bicarbonate and a mixture of sodium bicarbonate and carbonate ("Carbicarb") on skeletal muscle pH and hemodynamic status in rats with hypovolemic shock. Beech, J.S., Nolan, K.M., Iles, R.A., Cohen, R.D., Williams, S.C., Evans, S.J. Metab. Clin. Exp. (1994) [Pubmed]
  13. Effect of Magadi soda treatment on the tannin content and in-vitro nutritive value of grain sorghums. Muindi, P.J., Thomke, S., Ekman, R. J. Sci. Food Agric. (1981) [Pubmed]
  14. Comparison of sodium bicarbonate, Carbicarb, and THAM during cardiopulmonary resuscitation in dogs. Bar-Joseph, G., Weinberger, T., Castel, T., Bar-Joseph, N., Laor, A., Bursztein, S., Ben Haim, S. Crit. Care Med. (1998) [Pubmed]
  15. Does the administration of carbicarb lead acutely to back-titration of non-bicarbonate buffers? Kamel, K.S. Clin. Nephrol. (1996) [Pubmed]
  16. Insights into electrolytic stabilization with weak polarization as treatment for archaeological copper objects. Adriaens, A., Dowsett, M., Leyssens, K., Van Gasse, B. Analytical and bioanalytical chemistry (2007) [Pubmed]
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