Disease relevance of carbonic acid

• A hypertonic solution of sodium bicarbonate, Carbicarb (an equimolar mixture of sodium bicarbonate and sodium carbonate [International Medication Systems, Ltd]), or sodium chloride or an isotonic solution of sodium chloride was infused into the right atrium over a 1-minute interval starting at the sixth minute of ventricular fibrillation [1].
• Improved hemodynamic function during hypoxia with Carbicarb, a new agent for the management of acidosis [2].
• We studied the effects of carbicarb in an animal preparation of hypoxic lactic acidosis (HLA) [2].
• CONCLUSIONS: In severe canine hemorrhagic shock, Carbicarb, bicarbonate, and hypertonic saline appear to possess similar hemodynamic properties despite the buffering properties of bicarbonate and Carbicarb [3].
• Safety and efficacy of intravenous Carbicarb in patients undergoing surgery: comparison with sodium bicarbonate in the treatment of mild metabolic acidosis. SPI Research Group. Study of Perioperative Ischemia [4].

High impact information on carbonic acid

• The liver pHi (normal = 6.99, hypoxia = 6.80) improved with carbicarb (to 6.92), but decreased further with NaHCO3 (to 6.40) [2].
• Stroke volume also improved with carbicarb but there was no change in pulmonary capillary wedge pressure, suggesting that carbicarb had a beneficial effect on myocardial contractility.(ABSTRACT TRUNCATED AT 250 WORDS)[2]
• Sodium bicarbonate as a CO2-generating buffer, Carbicarb and tromethamine as CO2-consuming buffers, or hypertonic saline placebo were injected as a bolus into the right atrium during CPR [5].
• OBJECTIVE: To compare the effects of hypertonic saline, sodium bicarbonate, and Carbicarb resuscitation on acid-base balance, hemodynamics, and oxygen dynamics in a reperfused, canine hemorrhagic shock model [3].
• After retransfusion, blood pressure, cardiac index, and oxygen dynamics temporarily improved in all groups, without significant improvement in the bicarbonate and Carbicarb-treated animals, despite their excellent acid-base status [3].

Chemical compound and disease context of carbonic acid

• STUDY OBJECTIVE: Carbicarb, sodium bicarbonate, and 5% dextrose were compared for effects on resuscitability in a canine model of electromechanical dissociation after ventricular fibrillation [6].
• The objective of this study was to determine whether attenuation or neutralization of cerebral acidosis by Carbicarb alters hippocampal glutamate levels, neuronal cell death, and neurologic deficits after reperfusion from asphyxial cardiac arrest in rats [7].

Biological context of carbonic acid

• Carbicarb therapy resulted in systemic alkalinization without major changes in arterial pCO2, cardiac output, or mean arterial blood pressure [8].
• Sodium sesquicarbonate for early lactation dairy cows fed corn silage-based diets [9].
• During 0 to 56 d postpartum, sodium sesquicarbonate did not affect milk yield or composition [10].
• The nutritive value for rats of high- and low-tannin sorghums treated with magadi soda [11].
• Forty-eight multiparous Holstein cows were blocked according to month of parturition, age, and previous milk yield and arranged in a randomized complete block design to evaluate the effect of a naturally occurring sodium sesquicarbonate on DMI, milk yield, milk composition, milk value, and systemic acid-base status [10].

Anatomical context of carbonic acid

• The effects of sodium bicarbonate and a mixture of sodium bicarbonate and carbonate ("Carbicarb") on skeletal muscle pH and hemodynamic status in rats with hypovolemic shock [12].

Associations of carbonic acid with other chemical compounds

• After therapy, the arterial pH rose with carbicarb (7.22 to 7.27, p less than .01), and fell with NaHCO3 (7.18 to 7.13, p less than .01) [2].
• Systemic utilization of lactate increased from 0.3 +/- 1.0 mmol/min (baseline) to 5.6 +/- 4.3 mmol/min (45 mins after treatment) in Carbicarb-treated patients, and increased from 1.0 +/- 0.6 mmol/min (baseline) to 1.5 +/- 1.3 mmol/min in the sodium bicarbonate-treated patients, p = .033 (between groups) [4].
• Urine composition was not affected by sodium sesquicarbonate, but urine pH (8.14 vs. 8.04) and total urine output as estimated by creatinine concentration were higher than that of controls [9].
• Effect of Magadi soda treatment on the tannin content and in-vitro nutritive value of grain sorghums [13].

Gene context of carbonic acid

• INTERVENTIONS: Patients were randomly assigned to receive either sodium bicarbonate (1 mEq sodium/mL, n = 18) or 1 mol Carbicarb (1 mEq sodium/mL, n = 18) administered by intravenous bolus over a 30-sec period [4].

Analytical, diagnostic and therapeutic context of carbonic acid

• Comparison of sodium bicarbonate, Carbicarb, and THAM during cardiopulmonary resuscitation in dogs [14].
• RESULTS: As compared to the NaCl and the time control groups, the administration of carbicarb led to significant alkalinization of the ECF, pH rose from 7.23 +/- 0.02 to 7.34 +/- 0.03 [15].
• Immersion of corroded copper artefacts in dilute sodium sesquicarbonate solution is a well-recognized stabilization technique-especially in the conservation of objects recovered from marine environments and therefore saturated with chlorides [16].

References