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Chemical Compound Review:

AC1L3FYW N-propylprop-2-enamide

Synonyms: CTK0J3635, AR-1K8130, AKOS009808080, AC1Q5BJ2, A833757, ...

Hirose, M. et al., Perng, C.K. et al., Kim, J. et al., Gan, D. et al., Nagira, T. et al., et al.

Kim, Kim, Jeong, Park, Cheol Kim, Chun, Kim,

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Disease relevance of N-propylacrylamide

Adhesion behavior of monocytes, macrophages, and foreign body giant cells on poly (N-isopropylacrylamide) temperature-responsive surfaces [1].
As a model system, CD34-positive human acute myeloid leukemia cells (KG-1) were specifically separated from human T lymphoma cells (Jurkat) by applying anti-CD34 conjugated with poly-N-isopropylacrylamide in the aqueous two-phase system [2].

Psychiatry related information on N-propylacrylamide

In order to estimate response time of the clamper, the characteristic transition time of PNIPAAm film from hydrophilic to hydrophobic condition was investigated [3].

High impact information on N-propylacrylamide

Thermoresponsive, core--shell poly-N-isopropylacrylamide (p-NIPAm) nanoparticles (microgels) have been synthesized by seed and feed precipitation polymerization, and the influence of chemical differentiation between the core and shell polymers on the phase transition kinetics and thermodynamics has been examined [4].
The dynamics of the deswelling and swelling processes in thermoresponsive poly-N-isopropylacrylamide (pNIPAm) hydrogel nanoparticles have been studied by using time-resolved transmittance measurements, in combination with a nanosecond laser-induced temperature-jump (T-jump) technique [5].
Indomethacin-loaded polymeric nanocarriers based on amphiphilic polyphosphazenes with poly (N-isopropylacrylamide) and ethyl tryptophan as side groups: Preparation, in vitro and in vivo evaluation [6].
Technology developed to allow recovery of cells without enzyme treatment, involving a dish grafted with a thermoreactive polymer gel of poly-N-isopropylacrylamide (PIPAAm), was found to significantly enhance gap junctional intercellular communication (GJIC) in normal human dermal fibroblasts (NHDF cells) [7].
Confluent human aortic endothelial cells (HAECs) cultured on thermo-responsive culture dish grafted with poly (N-isopropylacrylamide) were recovered as a contiguous cell sheet [8].

Biological context of N-propylacrylamide

Temperature dependencies of kinetic and equilibrium parameters of urea hydrolysis catalyzed by native urease and the urease immobilized in a thermosensitive poly-N-isopropylacrylamide gel have been studied [9].
The results showed that the rate of cell growth and wound recovery in the hDMSC and gelatin/pNIPAAm/PP-treated group was significantly greater than those in the gelatin/pNIPAAm/PP-treated only group (P < .01) [10].
We report that human dermis-derived mesenchymal stem cells (hDMSCs) possess differentiation potential of epidermis facilitating wound healing in skin-defect nude mice in combination with the treatment using gelatin/thermosensitive poly N-isopropylacrylamide (pNIPAAm)/polypropylene (PP) [10].

Anatomical context of N-propylacrylamide

Endothelial cells were then seeded onto the same surfaces at 37 degrees C. These subsequently seeded endothelial cells adhered only to the now-exposed PIPAAm-grafted domains and could be co-cultured with the hepatocytes initially seeded at 37 degrees C in well-ordered patterns [11].
On the small intestine of a pig, a clamping mechanism was realized based on simple switching hydrophobic/hydrophilic surface conditions of PNIPAAm due to heating/cooling [3].

Associations of N-propylacrylamide with other chemical compounds

An acute toxicity test of the copolymer of NIPAM and NPAM was performed in comparison with that of the NIPAM monomer [12].
The endothelial cells adhered and proliferated on the PIPAAm-grafted surface, as on polystyrene tissue culture dishes at 37 degrees C. By reducing the temperature, confluent monolayers of cells detached from the PIPAAm surfaces without trypsin [11].

Gene context of N-propylacrylamide

Successful preparation of PIPAAm and the PIPAAm-PLA block copolymer was verified by gel permeation chromatography (GPC) and 1H-NMR spectroscopy [13].

Analytical, diagnostic and therapeutic context of N-propylacrylamide

The kinetics of crystallization of poly-N-isopropylacrylamide (PNIPAM) particles has been investigated using the UV-visible transmission spectroscopy [14].
Poly-N-isopropylacrylamide (PNIPAAm) thermosensibility makes this polymer a very attractive candidate for controlled drug delivery systems [15].
Poly-N-isopropylacrylamide (polyNIPAAm), a water-soluble, thermally precipitating synthetic polymer, has been conjugated together with a monoclonal antibody (MAb) and utilized in a novel separation method for an immunoassay [16].
One system involves a patterned co-culture of primary hepatocytes with endothelial cells utilizing patterned masked of the electron-beam cured, temperature-responsive polymer, poly (N-isopropylacrylamide) (PIPAAm) by masked electron beam irradiation [11].

References

Adhesion behavior of monocytes, macrophages, and foreign body giant cells on poly (N-isopropylacrylamide) temperature-responsive surfaces. Collier, T.O., Anderson, J.M., Kikuchi, A., Okano, T. J. Biomed. Mater. Res. (2002) [Pubmed]
Type-specific separation of animal cells in aqueous two-phase systems using antibody conjugates with temperature-sensitive polymers. Kumar, A., Kamihira, M., Galaev, I.Y., Mattiasson, B., Iijima, S. Biotechnol. Bioeng. (2001) [Pubmed]
Potential of Poly-(N-Isopropylacrylamide) hydrogel as a clamper of the microrobot in gastrointestinal tract. Kim, J., Kim, S., Jeong, Y., Park, S., Cheol Kim, H., Chun, K., Kim, B. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference (2005) [Pubmed]
Tunable swelling kinetics in core--shell hydrogel nanoparticles. Gan, D., Lyon, L.A. J. Am. Chem. Soc. (2001) [Pubmed]
Temperature-jump investigations of the kinetics of hydrogel nanoparticle volume phase transitions. Wang, J., Gan, D., Lyon, L.A., El-Sayed, M.A. J. Am. Chem. Soc. (2001) [Pubmed]
Indomethacin-loaded polymeric nanocarriers based on amphiphilic polyphosphazenes with poly (N-isopropylacrylamide) and ethyl tryptophan as side groups: Preparation, in vitro and in vivo evaluation. Zhang, J.X., Li, X.J., Qiu, L.Y., Li, X.H., Yan, M.Q., Yi Jin, n.u.l.l., Zhu, K.J. Journal of controlled release : official journal of the Controlled Release Society (2006) [Pubmed]
Enhancement of gap junctional intercellular communication of normal human dermal fibroblasts cultured on polystyrene dishes grafted with poly-N-isopropylacrylamide. Nagira, T., Matthew, S.B., Yamakoshi, Y., Tsuchiya, T. Tissue engineering. (2005) [Pubmed]
Novel approach for achieving double-layered cell sheets co-culture: overlaying endothelial cell sheets onto monolayer hepatocytes utilizing temperature-responsive culture dishes. Harimoto, M., Yamato, M., Hirose, M., Takahashi, C., Isoi, Y., Kikuchi, A., Okano, T. J. Biomed. Mater. Res. (2002) [Pubmed]
Effect of thermosensitive matrix-phase transition on urease-catalyzed urea hydrolysis. Eremeev, N.L., Kukhtin, A.V., Belyaeva, E.A., Kazanskaya, N.F. Appl. Biochem. Biotechnol. (1999) [Pubmed]
Evaluation of wound healing effect on skin-defect nude mice by using human dermis-derived mesenchyaml stem cells. Perng, C.K., Ku, H.H., Chiou, S.H., Chen, I.L., Tsai, F.T., Yang, Y.P., Chang, K.Y., Kao, C.L. Transplant. Proc. (2006) [Pubmed]
Temperature-Responsive surface for novel co-culture systems of hepatocytes with endothelial cells: 2-D patterned and double layered co-cultures. Hirose, M., Yamato, M., Kwon, O.H., Harimoto, M., Kushida, A., Shimizu, T., Kikuchi, A., Okano, T. Yonsei Med. J. (2000) [Pubmed]
Application of thermosensitive polymers as a new embolic material for intravascular neurosurgery. Matsumaru, Y., Hyodo, A., Nose, T., Ito, S., Hirano, T., Ohashi, S. Journal of biomaterials science. Polymer edition. (1996) [Pubmed]
Preparation and characterization of thermally responsive block copolymer micelles comprising poly(N-isopropylacrylamide-b-DL-lactide). Kohori, F., Sakai, K., Aoyagi, T., Yokoyama, M., Sakurai, Y., Okano, T. Journal of controlled release : official journal of the Controlled Release Society. (1998) [Pubmed]
Crystallization kinetics of thermosensitive colloids probed by transmission spectroscopy. Tang, S., Hu, Z., Cheng, Z., Wu, J. Langmuir : the ACS journal of surfaces and colloids. (2004) [Pubmed]
Effect of some physiological and non-physiological compounds on the phase transition temperature of thermoresponsive polymers intended for oral controlled-drug delivery. Eeckman, F., Amighi, K., Moës, A.J. International journal of pharmaceutics. (2001) [Pubmed]
A novel immunoassay system and bioseparation process based on thermal phase separating polymers. Monji, N., Hoffman, A.S. Appl. Biochem. Biotechnol. (1987) [Pubmed]

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