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Disease relevance of Paracentrotus


High impact information on Paracentrotus

  • DNA was extracted from Paracentrotus lividus embryos at the third S phase afer fertilization and analyzed with the electron microscope [2].
  • Here, we report the cloning of an orthopedia (Otp)-related gene from Paracentrotus lividus, PlOtp [3].
  • After proteolytic digestion of sperm tubulin from sea urchin Paracentrotus lividus, C-terminal peptides were isolated by chromatographic separations [4].
  • Pl-nectin is an ECM protein located on the apical surface of ectoderm cells of Paracentrotus lividus sea urchin embryo [5].
  • We have investigated the possibility of obtaining the same morphological effect as with lithium by utilizing Fabs against the maternal Bep4 protein that is localized in the animal part of Paracentrotus lividus egg and embryos [6].

Chemical compound and disease context of Paracentrotus

  • The present study was undertaken to evaluate the toxicity of aluminum sulfate, ferric chloride and their 1:1 mixture (Mix) on early development, fertilization and offspring quality in three sea urchins species (Sphaerechinus granularis, Paracentrotus lividus, Psammechinus microtuberculatus) and in mussels (Mytilus galloprovincialis) [7].

Biological context of Paracentrotus


Anatomical context of Paracentrotus


Associations of Paracentrotus with chemical compounds

  • Treatment of Paracentrotus lividus embryos with lithium, which is known to block the polyphosphoinositide (PPI) cycle, induces their development into vegetalized larvae [18].
  • An increase in the amount of cytoplasmic filamentous structures (cytoplasmic matrix and aster) which were recovered after hexylene glycol/Triton X-100 treatment of sea urchin eggs (Paracentrotus lividus) activated by 0.2-2.5 mM procaine was observed [19].
  • Intracellular pH (pHi) of sea urchin eggs (Paracentrotus lividus) was determined using DMO (dimethyloxazolidinedione) and a rapid filtration technique (P. Payan, J.P. Girard, R. Christen and C. Sardet (1981). Exp. Cell Res. 134, 339-344) [20].
  • The cytochrome b of the sea urchin Paracentrotus lividus is naturally resistant to myxothiazol and mucidin [21].
  • Two cDNA clones related to Paracentrotus lividus butanol-extracted proteins, presumably belonging to cell surface proteins, were isolated by a lambda gt11 expression library of ovary poly A+ RNA [22].

Gene context of Paracentrotus

  • Seawi is a major component of microtubule-ribonucleoprotein (MT-RNP) complexes isolated from two different species of sea urchin, Strongylocentrotus purpuratus and Paracentrotus lividus [23].
  • Three skeletal tissues of the adult echinoid Paracentrotus lividus (the pedicellaria primordium, the test, and the tooth) were immunolabeled with three sera raised against the total mineralization organic matrix and two specific matrix proteins (SM30 and SM50) from the embryo of the echinoid Strongylocentrotus purpuratus [24].
  • Marisa cornuarietis (Mollusc), Hyalella azteca (Crustacean), and Paracentrotus lividus (Echinoderm) demonstrated the ability to metabolize androgens through different pathways catalyzed by 5alpha-reductases (5alpha-R), hydroxysteroid dehydrogenases (HSD), hydroxylases, sulfotransferases (SULT), and fatty-acid acyl-CoA acyltransferases (ATAT) [25].
  • The protein displays a very high similarity with the Paracentrotus lividus homologue as it contains also the two leucine zipper-like domains which are thought to be involved in intramolecular interactions needed to expose the two DNA binding domains in the correct position for contacting DNA [26].
  • It is demonstrated by DNA electrophoresis analysis, morphological observations and TdT in situ reaction, that Paracentrotus embryos if treated with TPA plus heat undergo an apoptotic reaction [27].

Analytical, diagnostic and therapeutic context of Paracentrotus


  1. Toxicity of tributyltin and triphenyltin to early life-stages of Paracentrotus lividus (Echinodermata: Echinoidea). Novelli, A.A., Argese, E., Tagliapietra, D., Bettiol, C., Ghirardini, A.V. Environ. Toxicol. Chem. (2002) [Pubmed]
  2. Electron microscopic analysis of replicating DNA of sea urchin embryos. Baldari, C.T., Amaldi, F., Buongiorno-Nardelli, M. Cell (1978) [Pubmed]
  3. Spatially restricted expression of PlOtp, a Paracentrotus lividus orthopedia-related homeobox gene, is correlated with oral ectodermal patterning and skeletal morphogenesis in late-cleavage sea urchin embryos. Di Bernardo, M., Castagnetti, S., Bellomonte, D., Oliveri, P., Melfi, R., Palla, F., Spinelli, G. Development (1999) [Pubmed]
  4. Posttranslational modifications in the C-terminal tail of axonemal tubulin from sea urchin sperm. Mary, J., Redeker, V., Le Caer, J.P., Rossier, J., Schmitter, J.M. J. Biol. Chem. (1996) [Pubmed]
  5. Expression of univin, a TGF-beta growth factor, requires ectoderm-ECM interaction and promotes skeletal growth in the sea urchin embryo. Zito, F., Costa, C., Sciarrino, S., Poma, V., Russo, R., Angerer, L.M., Matranga, V. Dev. Biol. (2003) [Pubmed]
  6. Bep4 protein is involved in patterning along the animal-vegetal axis in the Paracentrotus lividus embryo. Romancino, D.P., Montana, G., Dalmazio, S., Di Carlo, M. Dev. Biol. (2001) [Pubmed]
  7. Cytogenetic, developmental, and biochemical effects of aluminum, iron, and their mixture in sea urchins and mussels. Pagano, G., His, E., Beiras, R., De Biase, A., Korkina, L.G., Iaccarino, M., Oral, R., Quiniou, F., Warnau, M., Trieff, N.M. Arch. Environ. Contam. Toxicol. (1996) [Pubmed]
  8. An open reading frame in intron seven of the sea urchin DNA-methyltransferase gene codes for a functional AP1 endonuclease. Cioffi, A.V., Ferrara, D., Cubellis, M.V., Aniello, F., Corrado, M., Liguori, F., Amoroso, A., Fucci, L., Branno, M. Biochem. J. (2002) [Pubmed]
  9. DNA (cytosine-5) methyltransferase turnover and cellular localization in developing Paracentrotus lividus sea urchin embryo. Di Giaimo, R., Locascio, A., Aniello, F., Branno, M., del Gaudio, R., Potenza, N., Geraci, G. Gene (2001) [Pubmed]
  10. Cloning and characterization of a developmentally regulated sea urchin cDNA encoding glutamine synthetase. Fucci, L., Piscopo, A., Aniello, F., Branno, M., Di Gregorio, A., Calogero, R., Geraci, G. Gene (1995) [Pubmed]
  11. Mitotic patterns and DNA synthesis in dinitrophenol-treated sea urchin eggs. Kojima, M.K., Czihak, G.K. Eur. J. Cell Biol. (1990) [Pubmed]
  12. Cloning, expression, and localization of a new member of a Paracentrotus lividus cell surface multigene family. Montana, G., Romancino, D.P., di Carlo, M.D. Mol. Reprod. Dev. (1996) [Pubmed]
  13. Centrifugation does not alter spatial distribution of 'BEP4' mRNA in paracentrotus lividus EGG. Costa, C., Rinaldi, A.M., Romancino, D.P., Cavalcante, C., Vizzini, A., Di Carlo, M. FEBS Lett. (1997) [Pubmed]
  14. Muscarinic signalling affects intracellular calcium concentration during the first cell cycle of sea urchin embryos. Harrison, P.K., Falugi, C., Angelini, C., Whitaker, M.J. Cell Calcium (2002) [Pubmed]
  15. Characterization of bep1 and bep4 antigens involved in cell interactions during Paracentrotus lividus development. Romancino, D.P., Ghersi, G., Montana, G., Bonura, A., Perriera, S., Di Carlo, M. Differentiation (1992) [Pubmed]
  16. Cytoskeleton of the unfertilized sea urchin egg. Foucault, G., Raymond, M.N., Pudles, J. Biol. Cell (1987) [Pubmed]
  17. Posttranslational modifications of axonemal tubulin. Mary, J., Redeker, V., Le Caer, J.P., Rossier, J., Schmitter, J.M. J. Protein Chem. (1997) [Pubmed]
  18. Effect of lithium on ionic balance and polyphosphoinositide metabolism during larval vegetalization of the sea urchin Paracentrotus lividus. Ciapa, B., Maggio, K. Dev. Biol. (1993) [Pubmed]
  19. Dual effect of procaine in sea urchin eggs. Inducer and inhibitor of microtubule assembly. Coffe, G., Foucault, G., Raymond, M.N., Pudles, J. Exp. Cell Res. (1985) [Pubmed]
  20. Mechanisms regulating intracellular pH in sea urchin eggs. Payan, P., Girard, J.P., Ciapa, B. Dev. Biol. (1983) [Pubmed]
  21. The cytochrome b of the sea urchin Paracentrotus lividus is naturally resistant to myxothiazol and mucidin. Degli Esposti, M., Ghelli, A., Butler, G., Roberti, M., Mustich, A., Cantatore, P. FEBS Lett. (1990) [Pubmed]
  22. Analysis of the sequence and expression during sea urchin development of two members of a multigenic family, coding for butanol-extractable proteins. Di Carlo, M., Montana, G., Bonura, A. Mol. Reprod. Dev. (1990) [Pubmed]
  23. Seawi--a sea urchin piwi/argonaute family member is a component of MT-RNP complexes. Rodriguez, A.J., Seipel, S.A., Hamill, D.R., Romancino, D.P., DI Carlo, M., Suprenant, K.A., Bonder, E.M. RNA (2005) [Pubmed]
  24. Ultrastructural localization of proteins involved in sea urchin biomineralization. Ameye, L., Hermann, R., Killian, C., Wilt, F., Dubois, P. J. Histochem. Cytochem. (1999) [Pubmed]
  25. Androgen metabolism in invertebrates and its modulation by xenoandrogens: a comparative study. Janer, G., Leblanc, G.A., Porte, C. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
  26. Cloning of two sea urchin DNA-binding proteins involved in mitochondrial DNA replication and transcription. Loguercio Polosa, P., Megli, F., Di Ponzio, B., Gadaleta, M.N., Cantatore, P., Roberti, M. Gene (2002) [Pubmed]
  27. Apoptosis in sea urchin embryos. Roccheri, M.C., Barbata, G., Cardinale, F., Tipa, C., Bosco, L., Oliva, O.A., Cascino, D., Giudice, G. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  28. Alpha-tubulin marker gene of neural territory of sea urchin embryos detected by whole-mount in situ hybridization. Gianguzza, F., Casano, C., Ragusa, M. Int. J. Dev. Biol. (1995) [Pubmed]
  29. Simultaneous determination of thiamin and riboflavin in the sea urchin, Paracentrotus lividus, by high-performance liquid chromatography. Rodríguez-Bernaldo De Quirós, A., López-Hernández, J., Simal-Lozano, J. International journal of food sciences and nutrition. (2004) [Pubmed]
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