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Chemical Compound Review

AG-F-98831     (2S)-2-acetamido-3- nitrososulfanyl...

Synonyms: AC1L3TWD, AC1Q5JSO, CTK5A5366, AR-1J3077, 56577-02-7, ...
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Disease relevance of S-nitroso-N-acetylcysteine


High impact information on S-nitroso-N-acetylcysteine


Anatomical context of S-nitroso-N-acetylcysteine


Associations of S-nitroso-N-acetylcysteine with other chemical compounds


Gene context of S-nitroso-N-acetylcysteine


Analytical, diagnostic and therapeutic context of S-nitroso-N-acetylcysteine

  • Immunohistochemical analysis using a cGMP-specific monoclonal antibody confirmed the presence of cGMP in the subsarcolemmal region, near nitric oxide synthase (NOS). cGMP measured by ELISA in control muscle (0.27 pmol/mg +/- 0.01 SE) was significantly increased by the NO donor S-nitroso-N-acetylcysteine 1 mM (0.55+/-0.05; N = 6; P < 0.001) [19].
  • The blood flow was statistically significantly (p<0.03) greater in the SNAC group than in the PBS group from 40 to 90 min of reperfusion [12].
  • This finding may give a rationale for the use of S-nitrosothiols, such as GSNO and SNAC, in the pharmacotherapy of hyperexcitatory disturbances of ejaculation (premature ejaculation) [14].


  1. Topically applied S-nitrosothiol-containing hydrogels as experimental and pharmacological nitric oxide donors in human skin. Seabra, A.B., Fitzpatrick, A., Paul, J., De Oliveira, M.G., Weller, R. Br. J. Dermatol. (2004) [Pubmed]
  2. Oral administration of S-nitroso-N-acetylcysteine prevents the onset of non alcoholic fatty liver disease in rats. de Oliveira, C.P., Simplicio, F.I., de Lima, V.M., Yuahasi, K., Lopasso, F.P., Alves, V.A., Abdalla, D.S., Carrilho, F.J., Laurindo, F.R., de Oliveira, M.G. World J. Gastroenterol. (2006) [Pubmed]
  3. S-nitroso-N-acetylcysteine protects skeletal muscle against reperfusion injury. Liu, K., Chen, L.E., Seaber, A.V., Urbaniak, J.R. Microsurgery. (1998) [Pubmed]
  4. Inhibition of sphincter of Oddi function by the nitric oxide carrier S-nitroso-N-acetylcysteine in rabbits and humans. Slivka, A., Chuttani, R., Carr-Locke, D.L., Kobzik, L., Bredt, D.S., Loscalzo, J., Stamler, J.S. J. Clin. Invest. (1994) [Pubmed]
  5. N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin. Loscalzo, J. J. Clin. Invest. (1985) [Pubmed]
  6. Hepatic gene expression profile associated with non-alcoholic steatohepatitis protection by S-nitroso-N-acetylcysteine in ob/ob mice. Souza de Oliveira, C.P., Stefano, J.T., de Lima, V.M., de S??, S.V., Simplicio, F.I., de Mello, E.S., Corr??a-Giannella, M.L., Ferreira Alves, V.A., Martins Laurindo, F.R., de Oliveira, M.G., Giannella-Neto, D., Carrilho, F.J. J. Hepatol. (2006) [Pubmed]
  7. Effect of nitric oxide on single skeletal muscle fibres from the mouse. Andrade, F.H., Reid, M.B., Allen, D.G., Westerblad, H. J. Physiol. (Lond.) (1998) [Pubmed]
  8. Regulation of cardiac myocyte contractile function by inducible nitric oxide synthase (iNOS): mechanisms of contractile depression by nitric oxide. Joe, E.K., Schussheim, A.E., Longrois, D., Mäki, T., Kelly, R.A., Smith, T.W., Balligand, J.L. J. Mol. Cell. Cardiol. (1998) [Pubmed]
  9. S-nitrosothiols as vasodilators: implications regarding tolerance to nitric oxide-containing vasodilators. Henry, P.J., Drummer, O.H., Horowitz, J.D. Br. J. Pharmacol. (1989) [Pubmed]
  10. Effects of S-nitroso-N-acetylcysteine on contractile function of reperfused skeletal muscle. Chen, L.E., Seaber, A.V., Nasser, R.M., Stamler, J.S., Urbaniak, J.R. Am. J. Physiol. (1998) [Pubmed]
  11. The effects of exogenous nitric oxide donor on motor functional recovery of reperfused peripheral nerve. Park, J.W., Qi, W.N., Cai, Y., Nunley, J.A., Urbaniak, J.R., Chen, L.E. The Journal of hand surgery. (2005) [Pubmed]
  12. Effect of a nitric oxide donor on microcirculation of acutely denervated skeletal muscle during reperfusion. Chou, C.H., Chen, L.E., Seaber, A.V., Urbaniak, J.R. Journal of reconstructive microsurgery. (2002) [Pubmed]
  13. Activation and inhibition of purified skeletal muscle calcium release channel by NO donors in single channel current recordings. Suko, J., Drobny, H., Hellmann, G. Biochim. Biophys. Acta (1999) [Pubmed]
  14. Effects of various nitric oxide-donating drugs on adrenergic tension of human seminal vesicles in vitro. Machtens, S., Ckert, S., Stief, C.G., Tsikas, D., Frlich, J.C., Jonas, U. Urology (2003) [Pubmed]
  15. Interference by S-nitroso compounds with the measurement of nitrate in methods requiring reduction of nitrate to nitrite by cadmium. Tsikas, D., Sandmann, J., Gutzki, F.M., Frölich, J.C. J. Chromatogr. B Biomed. Sci. Appl. (1999) [Pubmed]
  16. Antiatherogenic effects of S-nitroso-N-acetylcysteine in hypercholesterolemic LDL receptor knockout mice. Krieger, M.H., Santos, K.F., Shishido, S.M., Wanschel, A.C., Estrela, H.F., Santos, L., De Oliveira, M.G., Franchini, K.G., Spadari-Bratfisch, R.C., Laurindo, F.R. Nitric Oxide (2006) [Pubmed]
  17. In vitro effects of a novel class of nitric oxide (NO) donating compounds on isolated human erectile tissue. Seidler, M., Uckert, S., Waldkirch, E., Stief, C.G., Oelke, M., Tsikas, D., Sohn, M., Jonas, U. Eur. Urol. (2002) [Pubmed]
  18. Addition of nitric oxide donor S-nitroso-N-acetylcysteine to selective iNOS inhibitor 1400W further improves contractile function in reperfused skeletal muscle. Barker, J.U., Qi, W.N., Cai, Y., Urbaniak, J.R., Chen, L.E. Microsurgery. (2005) [Pubmed]
  19. Cyclic GMP is a second messenger by which nitric oxide inhibits diaphragm contraction. Abraham, R.Z., Kobzik, L., Moody, M.R., Reid, M.B., Stamler, J.S. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (1998) [Pubmed]
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