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Chemical Compound Review

Linsidomina     3-morpholin-4-yl-1-oxa-3- azonia-2...

Synonyms: Linsidomine, Linsidominum, SIN-I, sin-1, Lopac-M-184, ...
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Disease relevance of Lopac-M-184


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High impact information on Lopac-M-184


Chemical compound and disease context of Lopac-M-184


Biological context of Lopac-M-184


Anatomical context of Lopac-M-184


Associations of Lopac-M-184 with other chemical compounds


Gene context of Lopac-M-184


Analytical, diagnostic and therapeutic context of Lopac-M-184


  1. Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia. Sogawa, K., Numayama-Tsuruta, K., Ema, M., Abe, M., Abe, H., Fujii-Kuriyama, Y. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms. Brandi, M.L., Hukkanen, M., Umeda, T., Moradi-Bidhendi, N., Bianchi, S., Gross, S.S., Polak, J.M., MacIntyre, I. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells. Cobbs, C.S., Whisenhunt, T.R., Wesemann, D.R., Harkins, L.E., Van Meir, E.G., Samanta, M. Cancer Res. (2003) [Pubmed]
  4. The effects of linsidomine on portal hypertension. Lautt, W.W. Hepatology (1992) [Pubmed]
  5. Nitric oxide donor prevents hepatic and systemic perfusion decrease induced by endotoxin in anesthetized rabbits. Pastor, C.M., Losser, M.R., Payen, D. Hepatology (1995) [Pubmed]
  6. Preliminary results with the nitric oxide donor linsidomine chlorhydrate in the treatment of human erectile dysfunction. Stief, C.G., Holmquist, F., Djamilian, M., Krah, H., Andersson, K.E., Jonas, U. J. Urol. (1992) [Pubmed]
  7. Biosynthesis of nitric oxide activates iron regulatory factor in macrophages. Drapier, J.C., Hirling, H., Wietzerbin, J., Kaldy, P., Kühn, L.C. EMBO J. (1993) [Pubmed]
  8. gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implications. Christen, S., Woodall, A.A., Shigenaga, M.K., Southwell-Keely, P.T., Duncan, M.W., Ames, B.N. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  9. Effect of the direct nitric oxide donors linsidomine and molsidomine on angiographic restenosis after coronary balloon angioplasty. The ACCORD Study. Angioplastic Coronaire Corvasal Diltiazem. Lablanche, J.M., Grollier, G., Lusson, J.R., Bassand, J.P., Drobinski, G., Bertrand, B., Battaglia, S., Desveaux, B., Juillière, Y., Juliard, J.M., Metzger, J.P., Coste, P., Quiret, J.C., Dubois-Randé, J.L., Crochet, P.D., Letac, B., Boschat, J., Virot, P., Finet, G., Le Breton, H., Livarek, B., Leclercq, F., Béard, T., Giraud, T., Bertrand, M.E. Circulation (1997) [Pubmed]
  10. Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants. Khatsenko, O.G., Gross, S.S., Rifkind, A.B., Vane, J.R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  11. Nitric oxide donors protect cultured rat astrocytes from 1-methyl-4-phenylpyridinium-induced toxicity. Tsai, M.J., Lee, E.H. Free Radic. Biol. Med. (1998) [Pubmed]
  12. Comparative efficacy of the intravenous administration of linsidomine, a direct nitric oxide donor, and isosorbide dinitrate in severe unstable angina. A French multicentre study. French Group of Investigators. Delonca, J., Giraud, T., Beaufils, P., Dupuis, B., Haïat, R., Théry, C. Eur. Heart J. (1997) [Pubmed]
  13. Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions. Klingstr??m, J., Akerstr??m, S., Hardestam, J., Stoltz, M., Simon, M., Falk, K.I., Mirazimi, A., Rottenberg, M., Lundkvist, A. Eur. J. Immunol. (2006) [Pubmed]
  14. Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite. Thomas, S.R., Davies, M.J., Stocker, R. Chem. Res. Toxicol. (1998) [Pubmed]
  15. Dehydroepiandrosterone inhibits the death of immunostimulated rat C6 glioma cells deprived of glucose. Shin, C.Y., Choi, J.W., Jang, E.S., Ju, C., Kim, W.K., Kim, H.C., Choi, C.R., Ko, K.H. Brain Res. (2001) [Pubmed]
  16. HLA-DR-mediated signals for hematopoiesis and induction of apoptosis involve but are not limited to a nitric oxide pathway. Lee, J.W., Beckham, C., Michel, B.R., Rosen, H., Deeg, H.J. Blood (1997) [Pubmed]
  17. o-raffinose cross-linked hemoglobin improves the hemostatic defect associated with anemia and thrombocytopenia in rabbits. Lee, D.H., Bardossy, L., Peterson, N., Blajchman, M.A. Blood (2000) [Pubmed]
  18. Systemic and splanchnic hemodynamic effects of molsidomine in rats with carbon tetrachloride-induced cirrhosis. Desmorat, H., Vinel, J.P., Lahlou, O., Pipy, B., Badia, P., Cales, P., Combis, J.M., Souqual, M.C., Pascal, J.P. Hepatology (1991) [Pubmed]
  19. Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition. Alano, C.C., Ying, W., Swanson, R.A. J. Biol. Chem. (2004) [Pubmed]
  20. Exogenous nitric oxide and endogenous glucose-stimulated beta-cell nitric oxide augment insulin release. Smukler, S.R., Tang, L., Wheeler, M.B., Salapatek, A.M. Diabetes (2002) [Pubmed]
  21. Sympathetic stimulation overrides flow-mediated endothelium-dependent epicardial coronary vasodilation in transplant patients. Aptecar, E., Dupouy, P., Benvenuti, C., Mazzucotelli, J.P., Teiger, E., Geschwind, H., Castaigne, A., Loisance, D., Dubois-Rande, J.L. Circulation (1996) [Pubmed]
  22. Neointima formation impairs endothelial muscarinic receptors while enhancing prostacyclin-mediated responses in the rabbit carotid artery. De Meyer, G.R., Bult, H., Van Hoydonck, A.E., Jordaens, F.H., Buyssens, N., Herman, A.G. Circ. Res. (1991) [Pubmed]
  23. Hirudin and nitrates inhibit the thrombin-induced release of endothelin from the intact porcine aorta. Boulanger, C.M., Lüscher, T.F. Circ. Res. (1991) [Pubmed]
  24. Increased sensitivity of fibroblasts from amyotrophic lateral sclerosis patients to oxidative stress. Aguirre, T., Van Den Bosch, L., Goetschalckx, K., Tilkin, P., Mathijs, G., Cassiman, J.J., Robberecht, W. Ann. Neurol. (1998) [Pubmed]
  25. Nitroxides increase the detectable amount of nitric oxide released from endothelial cells. Zöllner, S., Haseloff, R.F., Kirilyuk, I.A., Blasig, I.E., Rubanyi, G.M. J. Biol. Chem. (1997) [Pubmed]
  26. Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase. Murphy, M.E., Sies, H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  27. Nitric oxide synthase (NOS3)-mediated cholinergic modulation of Ca2+ current in adult rabbit atrioventricular nodal cells. Han, X., Kobzik, L., Balligand, J.L., Kelly, R.A., Smith, T.W. Circ. Res. (1996) [Pubmed]
  28. Nitric oxide regulates shear stress-induced early growth response-1. Expression via the extracellular signal-regulated kinase pathway in endothelial cells. Chiu, J.J., Wung, B.S., Hsieh, H.J., Lo, L.W., Wang, D.L. Circ. Res. (1999) [Pubmed]
  29. Electrophysiological and immunocytochemical evidence for a cGMP-mediated inhibition of subfornical organ neurons by nitric oxide. Rauch, M., Schmid, H.A., deVente, J., Simon, E. J. Neurosci. (1997) [Pubmed]
  30. Peroxynitrite irreversibly inactivates the human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) in human breast cancer cells: a cellular and mechanistic study. Dairou, J., Atmane, N., Rodrigues-Lima, F., Dupret, J.M. J. Biol. Chem. (2004) [Pubmed]
  31. Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors. Takahashi, K., Hara, E., Suzuki, H., Sasano, H., Shibahara, S. J. Neurochem. (1996) [Pubmed]
  32. Interaction of heme oxygenase-2 with nitric oxide donors. Is the oxygenase an intracellular 'sink' for NO? Ding, Y., McCoubrey, W.K., Maines, M.D. Eur. J. Biochem. (1999) [Pubmed]
  33. Regulation of the expression of cyclooxygenase-2 by nitric oxide in rat peritoneal macrophages. Habib, A., Bernard, C., Lebret, M., Creminon, C., Esposito, B., Tedgui, A., Maclouf, J. J. Immunol. (1997) [Pubmed]
  34. Lack of interaction between nitric oxide and the redox modulatory site of the NMDA receptor. Aizenman, E., Potthoff, W.K. Br. J. Pharmacol. (1999) [Pubmed]
  35. Superoxide dismutase activity in organotypic midbrain-striatum co-cultures is associated with resistance of dopaminergic neurons to excitotoxicity. Katsuki, H., Tomita, M., Takenaka, C., Shirakawa, H., Shimazu, S., Ibi, M., Kume, T., Kaneko, S., Akaike, A. J. Neurochem. (2001) [Pubmed]
  36. Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons. Lin, Q., Palecek, J., Palecková, V., Peng, Y.B., Wu, J., Cui, M., Willis, W.D. J. Neurophysiol. (1999) [Pubmed]
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