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Chemical Compound Review

Basthioryl     1,1,3,3-tetramethylthiourea

Synonyms: TMTU, CHEMBL12214, CCRIS 4871, NA-101, AG-E-88872, ...
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Disease relevance of Basthioryl


High impact information on Basthioryl


Biological context of Basthioryl


Anatomical context of Basthioryl


Associations of Basthioryl with other chemical compounds


Gene context of Basthioryl

  • The asbestos-induced increase in TNF-alpha, as well as in interleukin-1 alpha, and their inhibition by tetramethylthiourea occurred at the transcriptional level [15].
  • DMTU and TMTU attenuated (P < 0.001) the MC + IgGAg-induced migration of Mphi as well as IgGAg-induced mRNA expression for RANTES and MCP-1 [16].
  • Rats treated with each of the alkylthioureas exhibited marked increases of mEH and rGSTA2 mRNA levels with TMT being the most effective [3].


  1. Schwann cell proliferation in the sciatic nerve of hypothyroid chick embryos studied by autoradiography and image analysis. Usson, Y., Saxod, R. J. Neurocytol. (1988) [Pubmed]
  2. Studies on the goitrogenic mechanism of action of N,N,N',N'-tetramethylthiourea. Freyberger, A., Ahr, H.J. Toxicology (2006) [Pubmed]
  3. Thioureas differentially induce rat hepatic microsomal epoxide hydrolase and rGSTA2 irrespective of their oxygen radical scavenging effect: effects on toxicant-induced liver injury. Kim, S.G., Kim, H.J., Yang, C.H. Chem. Biol. Interact. (1999) [Pubmed]
  4. Silica-induced activation of c-Jun-NH2-terminal amino kinases, protracted expression of the activator protein-1 proto-oncogene, fra-1, and S-phase alterations are mediated via oxidative stress. Shukla, A., Timblin, C.R., Hubbard, A.K., Bravman, J., Mossman, B.T. Cancer Res. (2001) [Pubmed]
  5. Molecular regulation of IL-6 activation by asbestos in lung epithelial cells: role of reactive oxygen species. Simeonova, P.P., Toriumi, W., Kommineni, C., Erkan, M., Munson, A.E., Rom, W.N., Luster, M.I. J. Immunol. (1997) [Pubmed]
  6. Cigarette smoke produces airway wall remodeling in rat tracheal explants. Wang, R.D., Tai, H., Xie, C., Wang, X., Wright, J.L., Churg, A. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  7. Relationship of fiber surface iron and active oxygen species to expression of procollagen, PDGF-A, and TGF-beta(1) in tracheal explants exposed to amosite asbestos. Dai, J., Churg, A. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  8. Oxidative stress can activate the epidermal platelet-activating factor receptor. Travers, J.B. J. Invest. Dermatol. (1999) [Pubmed]
  9. Crocidolite activates NF-kappa B and MIP-2 gene expression in rat alveolar epithelial cells. Role of mitochondrial-derived oxidants. Driscoll, K.E., Carter, J.M., Howard, B.W., Hassenbein, D., Janssen, Y.M., Mossman, B.T. Environ. Health Perspect. (1998) [Pubmed]
  10. Morphometric analysis of the cerebellar Purkinje cell in the developing normal and hypothyroid chick. Bouvet, J., Usson, Y., Legrand, J. Int. J. Dev. Neurosci. (1987) [Pubmed]
  11. Correlation between the molecular structure of N-alkylureas and N-alkylthioureas and their teratogenic properties. Teramoto, S., Kaneda, M., Aoyama, H., Shirasu, Y. Teratology (1981) [Pubmed]
  12. Interleukin-8 levels in human lung epithelial cells are increased in response to coal fly ash and vary with the bioavailability of iron, as a function of particle size and source of coal. Smith, K.R., Veranth, J.M., Hu, A.A., Lighty, J.S., Aust, A.E. Chem. Res. Toxicol. (2000) [Pubmed]
  13. Electronic tuning of the lability of Pt(II) complexes through pi-acceptor effects. Correlations between thermodynamic, kinetic, and theoretical parameters. Hofmann, A., Jaganyi, D., Munro, O.Q., Liehr, G., van Eldik, R. Inorganic chemistry. (2003) [Pubmed]
  14. Effects of modulators of the production and degradation of hydrogen peroxide on erythropoietin synthesis. Canbolat, O., Fandrey, J., Jelkmann, W. Respiration physiology. (1998) [Pubmed]
  15. Iron and reactive oxygen species in the asbestos-induced tumor necrosis factor-alpha response from alveolar macrophages. Simeonova, P.P., Luster, M.I. Am. J. Respir. Cell Mol. Biol. (1995) [Pubmed]
  16. Receptor mediated endocytosis by mesangial cells modulates transmigration of macrophages. Singhal, P.C., Gupta, S., Sharma, P., Shah, H., Shah, N., Patel, P. Inflammation (2000) [Pubmed]
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