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Gene Review

Ptafr  -  platelet-activating factor receptor

Mus musculus

Synonyms: PAF receptor, PAF-R, PAFR, PAFr, Platelet-activating factor receptor
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Disease relevance of Ptafr


Psychiatry related information on Ptafr

  • Taken together, these results demonstrate that PMS777 possesses dual activities for PAF receptor antagonism and AChE inhibition, suggesting that this compound may be a promising lead compound for further investigation related to the treatment for Alzheimer's disease [5].
  • These results suggest that BN-50730, a PAF receptor antagonist, produced retrograde amnesia and physostigmine attenuated BN-50730-induced amnesia possibly through increased concentration of cerebral acetylcholine and a consequent increase in PAF release [6].

High impact information on Ptafr

  • The levels of PAF production and PAFR mRNA expression in the spinal cord (SC) correlated with the EAE symptoms [7].
  • To investigate the role of platelet-activating factor (PAF) in this disease, PAF receptor (PAFR) KO (PAFR-KO) and wild-type (WT) mice, on a C57BL/6 genetic background, were immunized with myelin oligodendrocyte glycoprotein 35-55 [7].
  • In addition to the well-known role of PAF as a proinflammatory lipid mediator, we propose that the PAF receptor senses cellular damage through the recognition of PAF and/or PAF-like molecules, such as oxidized phosphatidylcholine, which activates cytokine transcription and induces systemic immune suppression [8].
  • Treatment with the neurokinin (NK)(1) and NK(3) receptor antagonists attenuated the responses, whereas NK(2), calcitonin gene-related peptide, or platelet-activating factor receptor antagonists had no effect [9].
  • In this model the angiogenesis induced by TNF-alpha was shown to be inhibited by WEB 2170, a specific PAF receptor antagonist [10].

Chemical compound and disease context of Ptafr


Biological context of Ptafr


Anatomical context of Ptafr


Associations of Ptafr with chemical compounds


Regulatory relationships of Ptafr


Other interactions of Ptafr

  • We conclude that the association of beta-arrestin with the PAFr contributes to successful translocation of pneumococci [2].
  • We demonstrated that PAF-R was expressed in mouse endothelial cells and was functionally active in stimulating p42/p44 MAPK and phosphatidylinositol 3-kinase (PtdIns3'-kinase)/Akt activities [20].
  • 4 Pretreatment with PAFR antagonist UK-74,505 (1 mg kg(-1)) markedly prevented tissue injury, as assessed by the increase in vascular permeability, neutrophil accumulation, hemorrhage and TNF-alpha concentrations in the intestine and lungs [29].
  • Interestingly, the reperfusion-associated increases in tissue concentrations of IL-10 were significantly greater in PAFR(-/-) than wild-type mice [29].
  • This study confirms the presence of the G protein-linked PAF receptor in the 2-cell embryo and describes for the first time its normal pattern of expression during early development [30].

Analytical, diagnostic and therapeutic context of Ptafr


  1. Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development. Lu, D.P., Chandrakanthan, V., Cahana, A., Ishii, S., O'Neill, C. J. Cell. Sci. (2004) [Pubmed]
  2. beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae. Radin, J.N., Orihuela, C.J., Murti, G., Guglielmo, C., Murray, P.J., Tuomanen, E.I. Infect. Immun. (2005) [Pubmed]
  3. Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy. Hikiji, H., Ishii, S., Shindou, H., Takato, T., Shimizu, T. J. Clin. Invest. (2004) [Pubmed]
  4. Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice. Nagase, T., Ishii, S., Kume, K., Uozumi, N., Izumi, T., Ouchi, Y., Shimizu, T. J. Clin. Invest. (1999) [Pubmed]
  5. Pharmacological profile of PMS777, a new AChE inhibitor with PAF antagonistic activity. Li, J., Huang, H., Miezan Ezoulin, J.M., Gao, X.L., Massicot, F., Dong, C.Z., Heymans, F., Chen, H.Z. Int. J. Neuropsychopharmacol. (2007) [Pubmed]
  6. Effects of BN-50730 (PAF receptor antagonist) and physostigmine (AChE inhibitor) on learning and memory in mice. Singh, N., Sharma, A., Singh, M. Methods and findings in experimental and clinical pharmacology. (1997) [Pubmed]
  7. Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. Kihara, Y., Ishii, S., Kita, Y., Toda, A., Shimada, A., Shimizu, T. J. Exp. Med. (2005) [Pubmed]
  8. Platelet-activating factor, a molecular sensor for cellular damage, activates systemic immune suppression. Walterscheid, J.P., Ullrich, S.E., Nghiem, D.X. J. Exp. Med. (2002) [Pubmed]
  9. Association between kinin B(1) receptor expression and leukocyte trafficking across mouse mesenteric postcapillary venules. McLean, P.G., Ahluwalia, A., Perretti, M. J. Exp. Med. (2000) [Pubmed]
  10. Tumor necrosis factor alpha-induced angiogenesis depends on in situ platelet-activating factor biosynthesis. Montrucchio, G., Lupia, E., Battaglia, E., Passerini, G., Bussolino, F., Emanuelli, G., Camussi, G. J. Exp. Med. (1994) [Pubmed]
  11. Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination. Pedotti, R., DeVoss, J.J., Youssef, S., Mitchell, D., Wedemeyer, J., Madanat, R., Garren, H., Fontoura, P., Tsai, M., Galli, S.J., Sobel, R.A., Steinman, L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  12. Platelet activating factor receptor blockade ameliorates murine systemic lupus erythematosus. Baldi, E., Emancipator, S.N., Hassan, M.O., Dunn, M.J. Kidney Int. (1990) [Pubmed]
  13. Abrogation of MRL/lpr lupus nephritis by dietary flaxseed. Hall, A.V., Parbtani, A., Clark, W.F., Spanner, E., Keeney, M., Chin-Yee, I., Philbrick, D.J., Holub, B.J. Am. J. Kidney Dis. (1993) [Pubmed]
  14. PAF-induced death in NMRI mice--a suitable shock model for testing new PAF receptor antagonists. Correlation with eicosanoid related substances. Becker, K., Lueddeckens, G., Grupe, R., Förster, W. Prostaglandins Leukot. Essent. Fatty Acids (1993) [Pubmed]
  15. PAF antagonism modifies neuroprotective action of histone deacetylase and calcineurin phosphatase inhibitors in mice. Subbanna, P.K., Tyagi, M.G. Indian J. Exp. Biol. (2006) [Pubmed]
  16. Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor. Ishii, S., Nagase, T., Tashiro, F., Ikuta, K., Sato, S., Waga, I., Kume, K., Miyazaki, J., Shimizu, T. EMBO J. (1997) [Pubmed]
  17. Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology. Fillon, S., Soulis, K., Rajasekaran, S., Benedict-Hamilton, H., Radin, J.N., Orihuela, C.J., El Kasmi, K.C., Murti, G., Kaushal, D., Gaber, M.W., Weber, J.R., Murray, P.J., Tuomanen, E.I. J. Immunol. (2006) [Pubmed]
  18. A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. Elovitz, M.A., Wang, Z., Chien, E.K., Rychlik, D.F., Phillippe, M. Am. J. Pathol. (2003) [Pubmed]
  19. Platelet-activating factor receptor deficiency delays elimination of adult worms but reduces fecundity in Strongyloides venezuelensis-infected mice. Negrão-Corrêa, D., Souza, D.G., Pinho, V., Barsante, M.M., Souza, A.L., Teixeira, M.M. Infect. Immun. (2004) [Pubmed]
  20. Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase. Hudry-Clergeon, H., Stengel, D., Ninio, E., Vilgrain, I. FASEB J. (2005) [Pubmed]
  21. Receptor-dependent metabolism of platelet-activating factor in murine macrophages. Ohshima, N., Ishii, S., Izumi, T., Shimizu, T. J. Biol. Chem. (2002) [Pubmed]
  22. Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Ishii, S., Shimizu, T. Prog. Lipid Res. (2000) [Pubmed]
  23. A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages. Ishii, S., Matsuda, Y., Nakamura, M., Waga, I., Kume, K., Izumi, T., Shimizu, T. Biochem. J. (1996) [Pubmed]
  24. Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions. Huber, J., Vales, A., Mitulovic, G., Blumer, M., Schmid, R., Witztum, J.L., Binder, B.R., Leitinger, N. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  25. Lipoteichoic acid-induced nitric oxide production depends on the activation of platelet-activating factor receptor and Jak2. Han, S.H., Kim, J.H., Seo, H.S., Martin, M.H., Chung, G.H., Michalek, S.M., Nahm, M.H. J. Immunol. (2006) [Pubmed]
  26. Platelet activating factor receptor binding plays a critical role in jet fuel-induced immune suppression. Ramos, G., Kazimi, N., Nghiem, D.X., Walterscheid, J.P., Ullrich, S.E. Toxicol. Appl. Pharmacol. (2004) [Pubmed]
  27. Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity. Xu, Y., Tao, Y.X. Neuroreport (2004) [Pubmed]
  28. Dithiolane analogs of lignans inhibit interferon-gamma and lipopolysaccharide-induced nitric oxide production in macrophages. Hussaini, I.M., Zhang, Y.H., Lysiak, J.J., Shen, T.Y. Acta Pharmacol. Sin. (2000) [Pubmed]
  29. Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment. Souza, D.G., Pinho, V., Soares, A.C., Shimizu, T., Ishii, S., Teixeira, M.M. Br. J. Pharmacol. (2003) [Pubmed]
  30. Ontogeny of expression of a receptor for platelet-activating factor in mouse preimplantation embryos and the effects of fertilization and culture in vitro on its expression. Stojanov, T., O'Neill, C. Biol. Reprod. (1999) [Pubmed]
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