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Chemical Compound Review

Anisperimus     6-(diaminomethylideneamino) hexylcarbamoylm...

Synonyms: CHEMBL357764, AG-E-19613, CTK4D3566, LF-15-0195, AC1L451N, ...
 
 
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Disease relevance of LF 15-0195

 

High impact information on LF 15-0195

 

Biological context of LF 15-0195

 

Anatomical context of LF 15-0195

 

Associations of LF 15-0195 with other chemical compounds

 

Gene context of LF 15-0195

  • LF 15-0195-mediated sensitization to AICD was further confirmed in human peripheral T cells exposed to anti-CD3 antibodies, then cultured in the presence of interleukin-2 [4].
  • We show that LF 15-0195 administration at the time of MBP immunization reduces the incidence and severity of EAE in Lewis rats [5].
  • Together, these data demonstrate that short-term treatment with LF 15-0195 prevents MBP-immunized LEW rats from EAE by favoring the development of Foxp-3-expressing regulatory CD4 T cells [10].
  • Finally, we demonstrate that the tolerance induced by LF 15-0195 treatment is not dependent on the presence of TGF-beta [10].
  • LF 15-0195 inhibited B cell differentiation with a marked suppression of anti-CII IgG1 and IgG2a synthesis [2].
 

Analytical, diagnostic and therapeutic context of LF 15-0195

References

  1. LF 15-0195 prevents from the development and inhibits the progression of rat experimental autoimmune myasthenia gravis. Duplan, V., Dutartre, P., Druet, P., Saoudi, A. J. Neuroimmunol. (2002) [Pubmed]
  2. Longterm protection of mice against collagen-induced arthritis after short-term LF 15-0195 treatment: modulation of B and T lymphocyte activation. Ducoroy, P., de Fornel, D., Dubrez-Daloz, L., Solary, E., Dutartre, P. J. Rheumatol. (2003) [Pubmed]
  3. Beneficial effect of the immunosuppressant LF 15-0195 on passively induced rat experimental autoimmune encephalomyelitis. Duplan, V., Stennevin, A., Ipinazar, K., Druet, P., Dutartre, P., Saoudi, A. Transplant. Proc. (2002) [Pubmed]
  4. LF 15-0195 immunosuppressive agent enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level. Ducoroy, P., Micheau, O., Perruche, S., Dubrez-Daloz, L., de Fornel, D., Dutartre, P., Saas, P., Solary, E. Blood (2003) [Pubmed]
  5. LF 15-0195 inhibits the development of rat central nervous system autoimmunity by inducing long-lasting tolerance in autoreactive CD4 T cells. Duplan, V., Dutartre, P., Mars, L.T., Liblau, R.S., Druet, P., Saoudi, A. J. Immunol. (2003) [Pubmed]
  6. Monotherapy with LF 15-0195, an analogue of 15-deoxyspergualin, significantly prolongs renal allograft survival in monkeys. Yang, H., Chen, G., Kanai, N., Shum, J., Garcia, B., Huang, X., Min, W., Luo, Y., Dutartre, P., Zhong, R. Transplantation (2003) [Pubmed]
  7. Treatment with a short course of LF 15-0195 and continuous cyclosporin A attenuates acute xenograft rejection in a rat-to-mouse cardiac transplantation model. Wang, H., Hosiawa, K.A., Garcia, B., Shum, J.B., Dutartre, P., Kelvin, D.J., Zhong, R. Xenotransplantation (2003) [Pubmed]
  8. The immunosuppressant LF 15-0195 prevents collagen-induced arthritis with IL-10 down-regulation. Ducoroy, P., de Fornel, D., Chirade, F., Fontet, P., Dutartre, P. Transplant. Proc. (2001) [Pubmed]
  9. Synergistic tolerance induced by LF15-0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells. Min, W.P., Zhou, D., Ichim, T.E., Xia, X., Zhang, X., Yang, J., Huang, X., Garcia, B., Dutartre, P., Jevnikar, A.M., Strejan, G.H., Zhong, R. Transplantation (2003) [Pubmed]
  10. LF 15-0195 treatment protects against central nervous system autoimmunity by favoring the development of Foxp3-expressing regulatory CD4 T cells. Duplan, V., Beriou, G., Heslan, J.M., Bruand, C., Dutartre, P., Mars, L.T., Liblau, R.S., Cuturi, M.C., Saoudi, A. J. Immunol. (2006) [Pubmed]
  11. Long term transgene expression by hepatocytes transduced with retroviral vectors requires induction of immune tolerance to the transgene. Puppi, J., Guillonneau, C., Pichard, V., Bellodi-Privato, M., Cuturi, M.C., Anegon, I., Ferry, N. J. Hepatol. (2004) [Pubmed]
 
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