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Gene Review

BCHE  -  butyrylcholinesterase

Felis catus

 
 
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Disease relevance of BCHE

  • The source of the postsynaptic BuChE, which is apparently completely absent from the endoplasmic reticulum of the ganglion cells, remains unexplained [1].
  • Administration of purified human BChE has previously been demonstrated to protect against cocaine-associated cardiovascular toxicity in rats [2].
  • It was concluded that inhibition of pancreatic BuChe leads to cholinergic hyperstimulation of the acinar cell, which results in acute pancreatitis, and that pancreatic BuChE is essential for dogs and guinea pigs to downregulate cholinergic excitation [3].
  • In cats, which lack pancreatic BuChE, no pathological changes occurred after two, three, and six hours, whereas in the guinea pigs as in dogs, both having abundant pancreatic BuChE, vacuolization of the acinar cells, interstitial edema and vasculitis indicate acute edematous pancreatitis as early as two hours [3].
 

High impact information on BCHE

 

Chemical compound and disease context of BCHE

 

Biological context of BCHE

  • These results suggest that BChE could be an effective and rapid therapy for the treatment of life-threatening cocaine-induced cardiovascular effects in human while clearing the total body burden of cocaine [2].
 

Anatomical context of BCHE

 

Associations of BCHE with chemical compounds

 

Analytical, diagnostic and therapeutic context of BCHE

References

  1. Electron microscope localization of acetylcholinesterase and butyrylcholinesterase in the superior cervical ganglion of the cat. II. Preganglionically denervated ganglion. Davis, R., Koelle, G.B. J. Cell Biol. (1981) [Pubmed]
  2. Therapeutic use of butyrylcholinesterase for cocaine intoxication. Mattes, C.E., Lynch, T.J., Singh, A., Bradley, R.M., Kellaris, P.A., Brady, R.O., Dretchen, K.L. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  3. Effects of insecticide, diazinon, on pancreas of dog, cat and guinea pig. Frick, T.W., Dalo, S., O'Leary, J.F., Runge, W., Borner, J.W., Baraniewski, H., Dressel, T., Shearen, J.G., Goodale, R.L. J. Environ. Pathol. Toxicol. Oncol. (1987) [Pubmed]
  4. Electron microscope localization of acetylcholinesterase and butyrylcholinesterase in the superior cervical ganglion of the cat. I. Normal ganglion. Davis, R., Koelle, G.B. J. Cell Biol. (1978) [Pubmed]
  5. L-glutamic acid, a neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat. Koelle, G.B., Sanville, U.J., Thampi, N.S., Wall, S.J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  6. Demonstration of a neurotrophic factor for the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat. Koelle, G.B., Ruch, G.A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  7. Distributions of molecular forms of acetylcholinesterase and butyrylcholinesterase in nervous tissue of the cat. Koelle, G.B., Massoulié, J., Eugène, D., Melone, M.A., Boulla, G. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  8. Effects of sodium pentobarbital anesthesia and neurotrophic factor on the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat. Koelle, G.B., Ruch, G.A., Uchida, E. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  9. Glycyl-L-glutamine, a precursor, and glycyl-L-glutamic acid, a neurotrophic factor for maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat in vivo. Koelle, G.B., Sanville, U.J., Wall, S.J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  10. Regeneration of cholinesterases in the stellate and normal and denervated superior cervical ganglion of the cat following inactivation by sarin. Koelle, G.B., Ruch, G.A., Rickard, K.K., Sanville, U.J. J. Neurochem. (1982) [Pubmed]
  11. Fibers from the basolateral nucleus of the amygdala selectively innervate striosomes in the caudate nucleus of the cat. Ragsdale, C.W., Graybiel, A.M. J. Comp. Neurol. (1988) [Pubmed]
  12. Histochemical localization of acetylcholinesterase in relation to motor neurons and internuclear neurons of the cat abducens nucleus. Spencer, R.F., Baker, R. J. Neurocytol. (1986) [Pubmed]
  13. Direct neurotrophic action of glycyl-L-glutamine in the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat. Koelle, G.B., Sanville, U.J., Thampi, N.S. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
 
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