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MeSH Review

Laser Therapy, Low-Level

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Disease relevance of Laser Therapy, Low-Level


High impact information on Laser Therapy, Low-Level


Biological context of Laser Therapy, Low-Level


Anatomical context of Laser Therapy, Low-Level


Associations of Laser Therapy, Low-Level with chemical compounds

  • Efficacy of 904 nm gallium arsenide low level laser therapy in the management of chronic myofascial pain in the neck: a double-blind and randomize-controlled trial [1].
  • STUDY DESIGN/MATERIALS AND METHODS: We have investigated the effects of low power laser irradiation on the loss of electrical excitability of hippocampal brain slices after a transient exposure to a perfusion medium lacking oxygen and containing reduced glucose concentrations [15].
  • CONCLUSIONS: These findings provide preliminary evidence that low level laser therapy with Gallium Arsenide laser may be a promising adjunctive therapy for patients with tuberculosis [16].
  • CONCLUSION: LLLT accelerated healing, caused by the steroid, acting as a biostimulative coadjutant agent, balancing the undesirable effects of cortisone on the tissue healing process [9].
  • Unilateral cases of either type of epicondylitis (n = 283) were randomly allocated to one of three treatment groups according to the LLLT technique applied: (1) Trigger points; (2) Scanner; (3) Combination Treatment (i.e., TPs and scanner technique) [17].

Gene context of Laser Therapy, Low-Level

  • We assessed the effectiveness of LLLT in the treatment of RA and OA [18].
  • CONCLUSIONS: Light from a low-power laser (LLLT) may be valuable in the treatment of DS [19].
  • BACKGROUND AND OBJECTIVE: Mast cell activation by low-level laser therapy (LLLT), leading to degranulation and the release of mediators, may be one of the mechanisms by which LLLT can accelerate tissue repair in mammals [20].
  • On the other hand, LLLT by itself was found less effective than PHA [21].
  • It is time to test low level laser therapy in Great Britain [22].

Analytical, diagnostic and therapeutic context of Laser Therapy, Low-Level

  • RESULTS: In patients with RA, relative to a separate control group, LLLT reduced pain by 70% relative to placebo and reduced morning stiffness by 27.5 min (95% CI -52.0 to -2.9), and increased tip to palm flexibility by 1.3 cm (95% CI -1.7 to -0.8) [18].
  • Trials were identified by a literature search of Medline, Embase, and the Cochrane Controlled Trials Register. Only randomized controlled trials of LLLT for the treatment of patients with a clinical diagnosis of RA or OA were eligible [18].
  • There is a need to investigate the effects of these factors on effectiveness of LLLT for RA and OA in randomized controlled clinical trials [18].
  • OBJECTIVE: The aim of this study was to assess, through near-infrared Raman spectroscopy (NIRS), the incorporation of hydroxyapatite of calcium (CHA; approximately 960 cm(1))--on the healing bone around dental implants submitted or not to low-level laser therapy (LLLT) (lambda830 nm) [23].
  • On the one hand, this meta-analysis found that pooled data gave some evidence of a clinical effect, but the outcomes were in conflict, and it must therefore be concluded that firm documentation of the application of LLLT in RA is not possible [24].


  1. Efficacy of 904 nm gallium arsenide low level laser therapy in the management of chronic myofascial pain in the neck: a double-blind and randomize-controlled trial. Gur, A., Sarac, A.J., Cevik, R., Altindag, O., Sarac, S. Lasers in surgery and medicine. (2004) [Pubmed]
  2. Clinical evaluation of low-level laser therapy and fluoride varnish for treating cervical dentinal hypersensitivity. Corona, S.A., Nascimento, T.N., Catirse, A.B., Lizarelli, R.F., Dinelli, W., Palma-Dibb, R.G. Journal of oral rehabilitation. (2003) [Pubmed]
  3. In vitro laser ablation of natural marine biofilms. Nandakumar, K., Obika, H., Utsumi, A., Ooie, T., Yano, T. Appl. Environ. Microbiol. (2004) [Pubmed]
  4. Inhibition of prostaglandin E2 and interleukin 1-beta production by low-power laser irradiation in stretched human periodontal ligament cells. Shimizu, N., Yamaguchi, M., Goseki, T., Shibata, Y., Takiguchi, H., Iwasawa, T., Abiko, Y. J. Dent. Res. (1995) [Pubmed]
  5. Effect of laser therapy on attachment, proliferation and differentiation of human osteoblast-like cells cultured on titanium implant material. Khadra, M., Lyngstadaas, S.P., Haanaes, H.R., Mustafa, K. Biomaterials (2005) [Pubmed]
  6. Low-level laser therapy (LLLT) prevents oxidative stress and reduces fibrosis in rat traumatized Achilles tendon. Fillipin, L.I., Mauriz, J.L., Vedovelli, K., Moreira, A.J., Zettler, C.G., Lech, O., Marroni, N.P., González-Gallego, J. Lasers in surgery and medicine. (2005) [Pubmed]
  7. Double-blind randomized controlled trial of low-level laser therapy in carpal tunnel syndrome. Irvine, J., Chong, S.L., Amirjani, N., Chan, K.M. Muscle Nerve (2004) [Pubmed]
  8. Carpal tunnel syndrome pain treated with low-level laser and microamperes transcutaneous electric nerve stimulation: A controlled study. Naeser, M.A., Hahn, K.A., Lieberman, B.E., Branco, K.F. Archives of physical medicine and rehabilitation. (2002) [Pubmed]
  9. A histologic assessment of the influence of low-intensity laser therapy on wound healing in steroid-treated animals. Pessoa, E.S., Melhado, R.M., Theodoro, L.H., Garcia, V.G. Photomedicine and laser surgery. (2004) [Pubmed]
  10. Laser therapy improves healing of bone defects submitted to autologous bone graft. Weber, J.B., Pinheiro, A.L., de Oliveira, M.G., Oliveira, F.A., Ramalho, L.M. Photomedicine and laser surgery. (2006) [Pubmed]
  11. Laser therapy accelerates initial attachment and subsequent behaviour of human oral fibroblasts cultured on titanium implant material. A scanning electron microscope and histomorphometric analysis. Khadra, M., Kasem, N., Lyngstadaas, S.P., Haanaes, H.R., Mustafa, K. Clinical oral implants research. (2005) [Pubmed]
  12. Evaluation of low level laser therapy on primary healing of experimentally induced full thickness teat wounds in dairy cattle. Ghamsari, S.M., Taguchi, K., Abe, N., Acorda, J.A., Sato, M., Yamada, H. Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons. (1997) [Pubmed]
  13. Effect of LLLT Ga-Al-As (685 nm) on LPS-induced inflammation of the airway and lung in the rat. Aimbire, F., Albertine, R., de Magalhães, R.G., Lopes-Martins, R.A., Castro-Faria-Neto, H.C., Zângaro, R.A., Chavantes, M.C., Pacheco, M.T. Lasers in medical science. (2005) [Pubmed]
  14. Low-power laser irradiation increases cyclic GMP synthesis in penile smooth muscle cells in vitro. Kipshidze, N., Petersen, J.R., Vossoughi, J., Nikolaychik, V., Bakhutashvili, I., Roubin, G.S., Leon, M.B., Moses, J.W. Journal of clinical laser medicine & surgery. (2000) [Pubmed]
  15. Low power laser irradiation reduces ischemic damage in hippocampal slices in vitro. Iwase, T., Hori, N., Morioka, T., Carpenter, D.O. Lasers in surgery and medicine. (1996) [Pubmed]
  16. Role of gallium arsenide laser irradiation at 890 nm as an adjunctive to anti-tuberculosis drugs in the treatment of pulmonary tuberculosis. Puri, M.M., Arora, V.K. The Indian journal of chest diseases & allied sciences. (2003) [Pubmed]
  17. Treatment of medial and lateral epicondylitis--tennis and golfer's elbow--with low level laser therapy: a multicenter double blind, placebo-controlled clinical study on 324 patients. Simunovic, Z., Trobonjaca, T., Trobonjaca, Z. Journal of clinical laser medicine & surgery. (1998) [Pubmed]
  18. Low level laser therapy for osteoarthritis and rheumatoid arthritis: a metaanalysis. Brosseau, L., Welch, V., Wells, G., Tugwell, P., de Bie, R., Gam, A., Harman, K., Shea, B., Morin, M. J. Rheumatol. (2000) [Pubmed]
  19. Fungicidal effect of diode laser irradiation in patients with denture stomatitis. Maver-Biscanin, M., Mravak-Stipetic, M., Jerolimov, V., Biscanin, A. Lasers in surgery and medicine. (2004) [Pubmed]
  20. Effect of laser pulse repetition rate and pulse duration on mast cell number and degranulation. el Sayed, S.O., Dyson, M. Lasers in surgery and medicine. (1996) [Pubmed]
  21. The biological effects of 632.8-nm low energy He-Ne laser on peripheral blood mononuclear cells in vitro. Gulsoy, M., Ozer, G.H., Bozkulak, O., Tabakoglu, H.O., Aktas, E., Deniz, G., Ertan, C. J. Photochem. Photobiol. B, Biol. (2006) [Pubmed]
  22. It is time to test low level laser therapy in Great Britain. Moshkovska, T., Mayberry, J. Postgraduate medical journal. (2005) [Pubmed]
  23. Infrared laser light reduces loading time of dental implants: a Raman spectroscopic study. Lopes, C.B., Pinheiro, A.L., Sathaiah, S., Duarte, J., Cristinamartins, M. Photomedicine and laser surgery. (2005) [Pubmed]
  24. Low level laser therapy (classes I, II and III) in the treatment of rheumatoid arthritis. Brosseau, L., Welch, V., Wells, G., deBie, R., Gam, A., Harman, K., Morin, M., Shea, B., Tugwell, P. Cochrane database of systematic reviews (Online) (2000) [Pubmed]
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