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Chemical Compound Review

Budirol     1,5-dimethyl-2-phenyl-4- propan-2-yl...

Synonyms: Causyth, Cibalgina, Larodon, Isopropchin, Isopropyrine, ...
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Disease relevance of C12817


High impact information on C12817


Biological context of C12817


Anatomical context of C12817


Associations of C12817 with other chemical compounds


Gene context of C12817

  • Means recoveries (percent) and relative standard deviation of PLS, PCR and ILS methods were found to be 100.1+/-0.6, 101.4+/-1.6 and 100.1+/-0.6 for APAP; 100.9+/-3.2, 102.0+/-3.3 and 100.9+/-3.2 for PP; 99.9+/-3.5, 101.6+/-3.3 and 99.9+/-3.2 for CAF, respectively [16].
  • The purpose of this experiment was to determine the effect of a nonselective COX inhibitor, propyphenazone (isopropylantipyrine), on the development of the knee joint in rats [13].

Analytical, diagnostic and therapeutic context of C12817


  1. IgE-mediated immediate-type hypersensitivity to the pyrazolone drug propyphenazone. Himly, M., Jahn-Schmid, B., Pittertschatscher, K., Bohle, B., Grubmayr, K., Ferreira, F., Ebner, H., Ebner, C. J. Allergy Clin. Immunol. (2003) [Pubmed]
  2. Incorporation of propyphenazone in beard hair of a migraine patient. Yegles, M., Wenning, R. Forensic Sci. Int. (2000) [Pubmed]
  3. Propyphenazone-induced serum sickness. Torrelo, A., Soria, C., Rocamora, A., Ledo, A. International journal of dermatology. (1990) [Pubmed]
  4. Inhibition of human neutrophil oxidative burst by pyrazolone derivatives. Costa, D., Marques, A.P., Reis, R.L., Lima, J.L., Fernandes, E. Free Radic. Biol. Med. (2006) [Pubmed]
  5. Expression of the skin-homing receptor in peripheral blood lymphocytes from subjects with nonimmediate cutaneous allergic drug reactions. Blanca, M., Posadas, S., Torres, M.J., Leyva, L., Mayorga, C., Gonzalez, L., Juarez, C., Fernández, J., Santamaria, L.F. Allergy (2000) [Pubmed]
  6. Clean method for the simultaneous determination of propyphenazone and caffeine in pharmaceuticals by flow injection Fourier transform infrared spectrometry. Bouhsain, Z., Garrigues, S., de la Guardia, M. The Analyst. (1997) [Pubmed]
  7. Application of high-performance liquid chromatography with diode-array detection and on-line post-column photochemical derivatization to the determination of analgesics. Di Pietra, A.M., Gatti, R., Andrisano, V., Cavrini, V. Journal of chromatography. A. (1996) [Pubmed]
  8. Kinetics and metabolism of pyrazolones (propyphenazone, aminopyrine and dipyrone). Volz, M., Kellner, H.M. British journal of clinical pharmacology. (1980) [Pubmed]
  9. Topical provocation of fixed drug eruption. Alanko, K., Stubb, S., Reitamo, S. Br. J. Dermatol. (1987) [Pubmed]
  10. Effects of prenatal exposure to combination of acetaminophen, isopropylantipyrine and caffeine on intrauterine development in rats. Burdan, F. Human & experimental toxicology. (2002) [Pubmed]
  11. Somatic and skeleton development of rat foetuses following in-utero exposure to isopropylantipyrine (propyphenazone) during the second trimester of gestation. Burdan, F. Folia morphologica. (2000) [Pubmed]
  12. Biphasic effect of pyrazolone derivatives on drug-metabolizing enzyme in rat liver. Bien, E., Gebert, I., Skorka, G. Die Pharmazie. (1985) [Pubmed]
  13. Formation of the knee joint after prenatal propyphenazone (isopropylantipyrine) administration. Burdan, F. Cells Tissues Organs (Print) (2002) [Pubmed]
  14. Drugs and personal care products as ubiquitous pollutants: occurrence and distribution of clofibric acid, caffeine and DEET in the North Sea. Weigel, S., Kuhlmann, J., Hühnerfuss, H. Sci. Total Environ. (2002) [Pubmed]
  15. Celosomy is associated with prenatal exposure to cyclooxygenase inhibitors. Burdan, F., Szumilo, J., Dudka, J., Korobowicz, A., Klepacz, R. Pharmacol. Res. (2006) [Pubmed]
  16. Dissolution and assaying of multicomponent tablets by chemometric methods using computer-aided spectrophotometer. Dinç, E., Serin, C., Tuğcu-Demiröz, F., Doğanay, T. International journal of pharmaceutics. (2003) [Pubmed]
  17. 11C-labeled 4-isopropylantipyrine: preparation and biological evaluation as a blood flow tracer in positron emission tomography (PET). Stone-Elander, S., Ingvar, M., Johnström, P., Ehrin, E., Garmelius, B., Greitz, T., Nilsson, J.L., Resul, B., Smith, M.L., Widén, L. J. Med. Chem. (1985) [Pubmed]
  18. Rapid determination of propyphenazone in plasma by high-performance liquid chromatography. Rouan, M.C., Campestrini, J., Lecaillon, J.B., Godbillon, J. J. Chromatogr. (1992) [Pubmed]
  19. Analgesic activity of propyphenazone in patients with pain following oral surgery. Boerlin, V., Maeglin, B., Hägler, W., Kuhn, M., Nüesch, E. Eur. J. Clin. Pharmacol. (1986) [Pubmed]
  20. Evaluation of systemic provocation tests in patients with suspected allergic and pseudoallergic drug reactions. Hein, U.R., Chantraine-Hess, S., Worm, M., Zuberbier, T., Henz, B.M. Acta Derm. Venereol. (1999) [Pubmed]
  21. Paracetamol-propyphenazone interaction and formulation difficulties associated with eutectic formation in combination solid dosage forms. Zalac, S., Khan, M.Z., Gabelica, V., Tudja, M., Mestrović, E., Romih, M. Chem. Pharm. Bull. (1999) [Pubmed]
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