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Chemical Compound Review

Sulbenicillin     (2R,5R,6S)-3,3-dimethyl-7- oxo-6-[(2-phenyl...

Synonyms: Kedacillina, Sulfocillin, SBPC, Sulbenicilina, Sulbenicilline, ...
 
 
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Disease relevance of Sulbenicillin

 

High impact information on Sulbenicillin

 

Chemical compound and disease context of Sulbenicillin

 

Biological context of Sulbenicillin

  • Carbenicillin and sulbenicillin, when added to an incubation medium at a concentration as low as 1/16 MIC, increased phagocytosis and killing of P. aeruginosa by PMN [10].
  • The results of the multiple dose study indicated that there was no apparent change in the distribution or elimination kinetics of sulbenicillin after 2 g i.m. administration [11].
 

Anatomical context of Sulbenicillin

  • The results of the examination indicated that the transfer of sulbenicillin into the exudate tended to increase when 30 mg/day of serratiopeptidase was concomitantly given for 6 days, though further examination was thought necessary by increasing number of subjects and elaborating on the methodology [12].
  • Genetic control of sulbenicillin (SBPC)-induced T cell proliferation in mice [13].
  • Drug-induced lymphocyte proliferation in the experimental sulbenicillin (SBPC) rash of guinea pigs and the enhancement effects of interleukin 2 (IL2) [14].
  • LMOX, FMOX, CTX, CBPC and SBPC also showed dose-dependent inhibition of colony formation from erythroid progenitors (CFU-E and BFU-E) [15].
 

Analytical, diagnostic and therapeutic context of Sulbenicillin

References

  1. Comparative in vitro activities of SCE-129, sulbenicillin, gentamicin, and dibekacin against Pseudomonas. Tsuchiya, K., Kondo, M. Antimicrob. Agents Chemother. (1978) [Pubmed]
  2. Effect of ursodeoxycholate on the biliary excretion of cefotiam and sulbenicillin in patients with percutaneous transhepatic biliary drainage. Higashi, K., Hayakawa, T., Katagiri, K., Tsukada, K., Ito, K., Hoshino, M., Miyaji, M., Takeuchi, T., Yamamoto, T. Antimicrob. Agents Chemother. (1988) [Pubmed]
  3. Anomalous pH dependence of the reactions of carbenicillin and sulbenicillin with Bacillus cereus beta-lactamase I. Influence of the alpha-substituent charge on the kinetic parameters. Hardy, L.W., Nishida, C.H., Kirsch, J.F. Biochemistry (1984) [Pubmed]
  4. Clinical assessment of sulbenicillin in acute respiratory tract infection. Macchioni, P.L., Del Din, G., Filippi, G., Baricchi, R., Bertani, A., Portioli, I. Drugs under experimental and clinical research. (1985) [Pubmed]
  5. Pharmacokinetics of sulbenicillin, a new broad-spectrum semisynthetic penicillin. Hansen, I.B., Jacobsen, E., Weis, J. Clin. Pharmacol. Ther. (1975) [Pubmed]
  6. Placental transfer of disodium sulbenicillin. Miyakawa, I., Taniyama, K., Inoue, H., Lee, H.C., Mori, N. Antimicrob. Agents Chemother. (1982) [Pubmed]
  7. Factors affecting the quality of boar semen stored by means of dialysis. Bamba, K., Sone, M. J. Reprod. Fertil. (1981) [Pubmed]
  8. Using MTT viability assay to test the cytotoxicity of antibiotics and steroid to cultured porcine corneal endothelial cells. Wang, H.Z., Chang, C.H., Lin, C.P., Tsai, M.C. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (1996) [Pubmed]
  9. Antibiotic concentration in bile from patients with obstructive jaundice. II: in vivo and in vitro studies of prednisolone effect on sulbenicillin excretion in bile. Ker, C.G., Peng, C.F., Huang, T.J., Sheen, P.C. Taiwan Yi Xue Hui Za Zhi (1981) [Pubmed]
  10. Effect of antibiotics on the phagocytosis and killing of Pseudomonas aeruginosa by rabbit polymorphonuclear leukocytes. Nishida, M., Mine, Y., Nonoyama, S., Yokota, Y. Chemotherapy. (1976) [Pubmed]
  11. Sulbenicillin: pharmacokinetics and penetration into bronchial secretion in elderly patients. Ripa, S., Mignini, F., Patrizi, I., Ferrante, L., Prenna, M., Falcioni, E. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. (1987) [Pubmed]
  12. [Effects of a proteolytic-enzyme preparation used concomitantly with an antibiotic in osteoarticular infections (author's transl)]. Okumura, H., Watanabe, R., Kotoura, Y., Nakane, Y., Tangiku, O. The Japanese journal of antibiotics. (1977) [Pubmed]
  13. Genetic control of sulbenicillin (SBPC)-induced T cell proliferation in mice. Ikezawa, Z., Kawaguchi, H., Sato, M. J. Dermatol. (1986) [Pubmed]
  14. Drug-induced lymphocyte proliferation in the experimental sulbenicillin (SBPC) rash of guinea pigs and the enhancement effects of interleukin 2 (IL2). Ikezawa, Z., Aihara, M., Nagai, R. J. Dermatol. (1985) [Pubmed]
  15. Effect of antibiotics on colony formation from mouse granulocyte-macrophage progenitors (CFU-GM), megakaryocyte progenitors (CFU-M) and erythrocyte progenitors (CFU-E, BFU-E) in vitro. Maruyama, T., Kobayashi, F., Uchida, K., Hara, H. Pharmacol. Toxicol. (1989) [Pubmed]
  16. Stereoselective disposition of sulbenicillin in humans. Itoh, T., Watanabe, N., Ishida, M., Tsuda, Y., Koyano, S., Tsunoi, T., Shimada, H., Yamada, H. Antimicrob. Agents Chemother. (1998) [Pubmed]
 
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