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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

IL2  -  interleukin 2

Sus scrofa

Synonyms: IL-2, POIL2, TCGF
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Disease relevance of IL2


Psychiatry related information on IL2

  • Also, large individual differences in the magnitudes of Con A-induced proliferation and IL-2 production were seen for PBMC collected from individual pigs within each litter [6].

High impact information on IL2

  • We also report here that low concentrations of Pro-boroPro inhibit antigen-induced proliferation and interleukin 2 production in murine T-cell lines but do not inhibit the response of these T cells to the mitogen concanavalin A [7].
  • Following mitogen stimulation (phytohemagglutinin or concanavalin A), feline lymphocytes were maintained in medium containing feline interleukin 2 [2].
  • In contrast, the primary T cell proliferative responses to self-Ia antigens in the syngeneic mixed leukocyte reaction (SMLR) and to trinitrophenyl-modified syngeneic macrophages were blocked by CY A and this suppressive effect could not be corrected by addition of exogenous IL 2 [8].
  • However, the cellular infiltrate in the acceptance reaction was distinguished by less T-cell activation (interleukin-2 receptor+), less proliferation (proliferating cell nuclear antigen+) of infiltrating cells, and less graft cell apoptosis in arteries, tubules, glomeruli, and peritubular capillaries [9].
  • Previous studies have suggested that this phenomenon is related to limited class I-specific helper T cell activity as evidenced by the failure of antibody class switching in vivo and the ability of exogenous interleukin 2 to elicit antidonor responses in vitro [10].

Chemical compound and disease context of IL2


Biological context of IL2

  • The resulting porcine DNA sequence encodes a 154 residue IL-2 primary translation product [14].
  • Comparison of the mature, secreted form of porcine IL-2 with those of other species was carried out in an attempt to identify differences that might contribute to the observed differing species specificities [14].
  • Depleted PBMC produced IL-2 which accumulated in cultures instead of being rapidly consumed by IL-2 dependent cell growth [15].
  • Dietary protein deficiency and BCG vaccination appear to modulate antigen-driven cellular immunity in animals with tuberculosis by altering the production of, and the response to, IL-2 by PPD-stimulated lymphocytes [4].
  • This clone could mount an IL-2-dependent, tissue-specific, non-major histocompatibility complex (MHC)-restricted proliferative response to OD from rat, guinea pig and various strains of mice (including syngeneic OD), but not to SC, whether resting or activated, nor to astrocytes, kidney cells or Langerhans islets [16].

Anatomical context of IL2

  • Collectively, the data indicate that ascorbic acid selectively influences the proliferation of B lymphocytes and negatively acts on IL2 production by T lymphocytes when a threshold of saturation is exceeded [17].
  • Maturation of the mitogen responsiveness, and IL2 and IL6 production by neonatal swine leukocytes [18].
  • Among the immunized groups, inoculation with VPIL-6 induced the highest content of IgG (p < 0.05), the greatest bioactivity of IL-2 and the greatest proliferation of lymphocytes from the spleen of the mice [19].
  • This suppressive activity is not abrogated by addition of interleukin 2, suggesting that these suppressor cells do not inhibit the proliferation by absorption of the released lymphokine or by inhibition of its production [20].
  • Interleukin-2 receptor/p55(Tac)-inducing activity in porcine follicular fluids [21].

Associations of IL2 with chemical compounds


Other interactions of IL2


Analytical, diagnostic and therapeutic context of IL2


  1. Effects of boar seminal immunosuppressive fraction on production of cytokines by Concanavalin A-stimulated spleen cells and on proliferation of B lymphoma cell lines. Veselský, L., Holán, V., Zajícová, A., Dostál, J., Zelezná, B. Am. J. Reprod. Immunol. (2003) [Pubmed]
  2. Comparison of feline leukemia virus-infected and normal cat T-cell lines in interleukin 2-conditioned medium. Grant, C.K., Ernisse, B.J., Pontefract, R. Cancer Res. (1984) [Pubmed]
  3. Recombinant interleukin 2 as an adjuvant for vaccine-induced protection. Immunization of guinea pigs with herpes simplex virus subunit vaccines. Weinberg, A., Merigan, T.C. J. Immunol. (1988) [Pubmed]
  4. Dietary protein deficiency and Mycobacterium bovis BCG affect interleukin-2 activity in experimental pulmonary tuberculosis. McMurray, D.N., Mintzer, C.L., Bartow, R.A., Parr, R.L. Infect. Immun. (1989) [Pubmed]
  5. Daily or weekly therapy with resiquimod (R-848) reduces genital recurrences in herpes simplex virus-infected guinea pigs during and after treatment. Bernstein, D.I., Harrison, C.J., Tomai, M.A., Miller, R.L. J. Infect. Dis. (2001) [Pubmed]
  6. Genetic variation in Con A-induced production of interleukin 2 by porcine peripheral blood mononuclear cells. Edfors-Lilja, I., Bergström, M., Gustafsson, U., Magnusson, U., Fossum, C. Vet. Immunol. Immunopathol. (1991) [Pubmed]
  7. Inhibition of dipeptidyl aminopeptidase IV (DP-IV) by Xaa-boroPro dipeptides and use of these inhibitors to examine the role of DP-IV in T-cell function. Flentke, G.R., Munoz, E., Huber, B.T., Plaut, A.G., Kettner, C.A., Bachovchin, W.W. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  8. Effect of cyclosporin A on T cell function in vitro: the mechanism of suppression of T cell proliferation depends on the nature of the T cell stimulus as well as the differentiation state of the responding T cell. Dos Reis, G.A., Shevach, E.M. J. Immunol. (1982) [Pubmed]
  9. Acceptance reaction: intragraft events associated with tolerance to renal allografts in miniature swine. Shimizu, A., Yamada, K., Meehan, S.M., Sachs, D.H., Colvin, R.B. J. Am. Soc. Nephrol. (2000) [Pubmed]
  10. The failure of skin grafting to break tolerance to class I-disparate renal allografts in miniature swine despite inducing marked antidonor cellular immunity. Rosengard, B.R., Kortz, E.O., Ojikutu, C.A., Guzzetta, P.C., Sundt, T.M., Smith, C.V., Nakajima, K., Boorstein, S.M., Hill, G.S., Sachs, D.H. Transplantation (1991) [Pubmed]
  11. Locoregional therapy with polyethylene-glycol-modified interleukin-2 of an intradermally growing hepatocellular carcinoma in the guinea pig induces T-cell-mediated antitumor activity. Balemans, L.T., Mattijssen, V., Steerenberg, P.A., Van Driel, B.E., De Mulder, P.H., Den Otter, W. Cancer Immunol. Immunother. (1993) [Pubmed]
  12. Influence of isoprinosine on lymphocyte function in virus-infected feeder pigs. Flaming, K.P., Blecha, F., Fedorka-Cray, P.J., Anderson, G.A. Am. J. Vet. Res. (1989) [Pubmed]
  13. Influence of sodium diethyldithiocarbamate (Imuthiol) on lymphocyte function and growth in weanling pigs. Flaming, K.P., Thaler, R.C., Blecha, F., Nelssen, J.L. Comp. Immunol. Microbiol. Infect. Dis. (1988) [Pubmed]
  14. cDNA cloning of porcine interleukin 2 by polymerase chain reaction. Goodall, J.C., Emery, D.C., Bailey, M., English, L.S., Hall, L. Biochim. Biophys. Acta (1991) [Pubmed]
  15. Modulation of interleukin production by ascorbic acid. Schwager, J., Schulze, J. Vet. Immunol. Immunopathol. (1998) [Pubmed]
  16. Non-MHC-restricted, tissue-specific T cells recognizing autologous oligodendrocytes in the normal SJL/J mouse. Jewtoukoff, V., Bach, M.A. J. Autoimmun. (1988) [Pubmed]
  17. Influence of ascorbic acid on the response to mitogens and interleukin production of porcine lymphocytes. Schwager, J., Schulze, J. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1997) [Pubmed]
  18. Maturation of the mitogen responsiveness, and IL2 and IL6 production by neonatal swine leukocytes. Schwager, J., Schulze, J. Vet. Immunol. Immunopathol. (1997) [Pubmed]
  19. The immunoregulation of mice by somatic transgenic expression of porcine interleukin-6 gene and CpG sequence. Li, J., Gao, R., Wu, M., Meng, M., Tang, M., Shen, Y., Wang, L., Wu, X., Yin, X., Xie, H., Liu, S. Vet. Res. Commun. (2004) [Pubmed]
  20. Suppressor cells of popliteal lymph node origin are involved in the in vivo and in vitro control of experimental allergic encephalomyelitis effector cells in the Lewis rat. Chabannes, D., Borel, J.F. Eur. J. Immunol. (1991) [Pubmed]
  21. Interleukin-2 receptor/p55(Tac)-inducing activity in porcine follicular fluids. Takakura, K., Taii, S., Fukuoka, M., Yasuda, K., Tagaya, Y., Yodoi, J., Mori, T. Endocrinology (1989) [Pubmed]
  22. Immunomodulatory effects in vivo of recombinant porcine interferon gamma on leukocyte functions of immunosuppressed pigs. Saulnier, D., Martinod, S., Charley, B. Ann. Rech. Vet. (1991) [Pubmed]
  23. Drug-induced lymphocyte proliferation in the experimental sulbenicillin (SBPC) rash of guinea pigs and the enhancement effects of interleukin 2 (IL2). Ikezawa, Z., Aihara, M., Nagai, R. J. Dermatol. (1985) [Pubmed]
  24. Lysis of porcine trophoblast cells by endometrial natural killer-like effector cells in vitro does not require interleukin-2. Yu, Z., Croy, B.A., King, G.J. Biol. Reprod. (1994) [Pubmed]
  25. Specific tumor memory induced by polyethylene-glycol-modified interleukin-2 requires both helper and cytotoxic T cells. Balemans, L.T., Steerenberg, P.A., Kremer, B.H., Koppenhagen, F.J., De Mulder, P.H., Den Otter, W. Cancer Immunol. Immunother. (1995) [Pubmed]
  26. Potentiation of T-lymphocyte function by bleomycin. Parker, D., Turk, J.L. Immunopharmacology (1984) [Pubmed]
  27. Differential cytokine mRNA expression in swine whole blood and peripheral blood mononuclear cell cultures. Yancy, H., Ayers, S.L., Farrell, D.E., Day, A., Myers, M.J. Vet. Immunol. Immunopathol. (2001) [Pubmed]
  28. Immune responses of pigs after experimental infection with a European strain of Porcine reproductive and respiratory syndrome virus. Díaz, I., Darwich, L., Pappaterra, G., Pujols, J., Mateu, E. J. Gen. Virol. (2005) [Pubmed]
  29. Effects of fish oil on lymphocyte proliferation, cytokine production and intracellular signalling in weanling pigs. Liu, Y., Gong, L., Li, D., Feng, Z., Zhao, L., Dong, T. Archiv für Tierernährung. (2003) [Pubmed]
  30. Kinetics and localization of interleukin-2, interleukin-6, heat shock protein 70, and interferon gamma during intestinal-rerfusion injury. Braun, F., Hosseini, M., Wieland, E., Sattler, B., Müller, A.R., Fändrich, F., Kremer, B., Ringe, B. Transplant. Proc. (2004) [Pubmed]
  31. Posttherapy suppression of genital herpes simplex virus (HSV) recurrences and enhancement of HSV-specific T-cell memory by imiquimod in guinea pigs. Harrison, C.J., Miller, R.L., Bernstein, D.I. Antimicrob. Agents Chemother. (1994) [Pubmed]
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