Disease relevance of ZOMEPIRAC SODIUM

• A double-blind study comparing the analgesic efficacy of orally administered zomepirac sodium with intramuscularly (IM) administered morphine sulfate was conducted in 109 patients with acute postoperative pain [1].
• Two patients, after several weeks of zomepirac sodium use, experienced acute toxic eruption, fever, lymphadenopathy, arthralgias, angioedema of the hands, and eosinophilia [2].
• The effect of indication on hypersensitivity reactions associated with zomepirac sodium and other nonsteroidal antiinflammatory drugs [3].
• Anaphylactoid shock, disseminated intravascular coagulation, and anuric renal failure requiring dialysis occurred in a patient receiving zomepirac sodium for toothache [4].
• Effect of preischemia cyclooxygenase inhibition by zomepirac sodium on reflow, cerebral autoregulation, and EEG recovery in the cat after global ischemia [5].

High impact information on ZOMEPIRAC SODIUM

• Zomepirac sodium (ZS) (5 mg/kg i.v.) was used to evaluate the effects of preischemia cyclooxygenase inhibition on CBF (as assessed by 133Xe clearance), CBF-PaCO2 responsiveness, and electrophysiologic (EEG) parameters before and after a 15-min period of complete global ischemia produced by four-vessel occlusion and mild hypotension [5].
• Acetylsalicylic acid (200 mg/kg p.o.) but not zomepirac sodium (200 mg/kg p.o.) in combination with D-phenylalanine (500 mg/kg) produced a small statistically significant increase in aversive threshold [6].
• Inhibitors of prostaglandin synthesis-quinacrine hydrochloride and zomepirac sodium-caused a significant (P less than 0.05 and P less than 0.02, respectively) reduction in the fluid response when administered with or 30 min before ST [7].
• This report describes two patients with the clinical syndrome of reversible renal failure and nephrotic syndrome caused by the nonsteroidal anti-inflammatory agent, zomepirac sodium [8].
• Long-term therapy for the pain of osteoarthritis: a comparison of zomepirac sodium and aspirin [9].

Chemical compound and disease context of ZOMEPIRAC SODIUM

• In this long-term, double-blind, multicenter study, efficacy and safety of zomepirac sodium were compared with those of aspirin for treatment of the chronic pain associated with osteoarthritis in 607 patients, 405 of whom received zomepirac and 202 of whom received aspirin [9].

Biological context of ZOMEPIRAC SODIUM

• Plasma protein binding of zomepirac sodium [10].
• A double-blind study of zomepirac sodium and placebo in the treatment of muscle contraction headache [11].
• Three asthmatic patients with a history of bronchoconstriction after aspirin ingestion were challenged with a new analgesic, zomepirac sodium (Zomax), for determination of sensitivity to this drug [12].
• The chemistry, pharmacokinetics, pharmacology, clinical efficacy, adverse effects, physical dependence and tolerance, drug interactions, dosing, and cost of zomepirac sodium (Zomax, McNeil) are reviewed [13].

Anatomical context of ZOMEPIRAC SODIUM

• A sensitive, specific and rapid determination of 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic acid sodium salt dihydrate (zomepirac sodium, Zomax) in human plasma and urine by a continuous body fluid monitoring system based on high-performance liquid chromatography is described [14].

Associations of ZOMEPIRAC SODIUM with other chemical compounds

• A 12-hour evaluation of the analgesic efficacy of diflunisal, zomepirac sodium, aspirin, and placebo in postoperative oral surgery pain [15].

Gene context of ZOMEPIRAC SODIUM

• Zomepirac sodium, 100 mg, provided analgesia equal to oxycodone with APC in all assessments of pain intensity and pain relief [16].

Analytical, diagnostic and therapeutic context of ZOMEPIRAC SODIUM

• Zomepirac sodium was compared with placebo for relief of primary dysmenorrhea syndrome in a double-blind, crossover study of 47 patients [17].
• Voltammetric studies of zomepirac sodium and its determination in tablets by differential-pulse polarography [18].
• The intra-uterine contraceptive device -- an attempt to prevent pain and expulsion with zomepirac sodium [19].

References