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Chemical Compound Review

Sulfanblau     sodium2-[(4- diethylaminophenyl)-(4...

Synonyms: LYMPHAZURIN, Patentblau V, Disulphin Blau, ISOSULFAN BLUE, Sulphan Blue, ...
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Disease relevance of MOLI001013


High impact information on MOLI001013

  • Injection of isosulfan blue intradermally into the skin of the medial thigh consistently led to coloration of the central lymph node, whereas intradermal abdominal wall injections and intradermal lateral thigh injections resulted in coloration of the lateral lymph node [5].
  • Because a 1% sterile solution of methylene blue used for occult breast tumor localization has been shown to interfere with the estrogen-receptor protein (ERP) binding-capacity assay, isosulfan blue in a 1% injection was studied as a potential alternate stain [6].
  • Noninterference of isosulfan blue on estrogen-receptor activity [6].
  • RESULTS: In patients who received isosulfan blue dye alone (n=783) or a combination of blue dye and radiocolloid (n=4192), anaphylaxis was reported in .1% of subjects (5 of 4975) [7].
  • CONCLUSIONS: Microsurgical repair of varicoceles using isosulfan blue helps in identifying and preserving the lymphatic drainage [8].

Chemical compound and disease context of MOLI001013


Anatomical context of MOLI001013

  • Cytosols derived from ERP-positive lyophilized powders and human breast tissue were evaluated with and without varying levels of treatment with isosulfan blue [6].
  • CONCLUSION: We have shown that IB identifies immunologically active DLNs, does not interfere with expansion of lymphocytes in vitro, and, more importantly, has no detrimental effect on the ability of lymphocytes to induce tumor regression in vivo [11].
  • METHODS: Isosulfan blue was injected into the dermis at the leading edge of the vulvar lesion in 21 patients [12].
  • After mobilization of the colon and mesentery, 1 to 2 ml of isosulfan blue dye was injected subserosally around the tumor [13].
  • Twenty-two rats underwent lymphatic mapping in each distal lower extremity with various combinations of carbon dye and isosulfan blue dye [14].

Associations of MOLI001013 with other chemical compounds


Gene context of MOLI001013


Analytical, diagnostic and therapeutic context of MOLI001013


  1. Anaphylactoid reactions to isosulfan blue dye during breast cancer lymphatic mapping in patients given preoperative prophylaxis. Raut, C.P., Daley, M.D., Hunt, K.K., Akins, J., Ross, M.I., Singletary, S.E., Marshall, G.D., Meric-Bernstam, F., Babiera, G., Feig, B.W., Ames, F.C., Kuerer, H.M. J. Clin. Oncol. (2004) [Pubmed]
  2. Is a lymph node detected by the dye-guided method a true sentinel node in gastric cancer? Osaka, H., Yashiro, M., Sawada, T., Katsuragi, K., Hirakawa, K. Clin. Cancer Res. (2004) [Pubmed]
  3. Detection of metastases in sentinel lymph nodes of breast cancer patients by multiple-marker RT-PCR. Bostick, P.J., Huynh, K.T., Sarantou, T., Turner, R.R., Qi, K., Giuliano, A.E., Hoon, D.S. Int. J. Cancer (1998) [Pubmed]
  4. Adverse reactions to isosulfan blue during selective sentinel lymph node dissection in melanoma. Leong, S.P., Donegan, E., Heffernon, W., Dean, S., Katz, J.A. Ann. Surg. Oncol. (2000) [Pubmed]
  5. Lymphatic drainage of skin to a sentinel lymph node in a feline model. Wong, J.H., Cagle, L.A., Morton, D.L. Ann. Surg. (1991) [Pubmed]
  6. Noninterference of isosulfan blue on estrogen-receptor activity. Hirsch, J.I., Banks, W.L., Sullivan, J.S., Horsley, J.S. Radiology. (1989) [Pubmed]
  7. Surgical complications associated with sentinel lymph node biopsy: results from a prospective international cooperative group trial. Wilke, L.G., McCall, L.M., Posther, K.E., Whitworth, P.W., Reintgen, D.S., Leitch, A.M., Gabram, S.G., Lucci, A., Cox, C.E., Hunt, K.K., Herndon, J.E., Giuliano, A.E. Ann. Surg. Oncol. (2006) [Pubmed]
  8. Optimizing the outcome of microsurgical subinguinal varicocelectomy using isosulfan blue: a prospective randomized trial. Schwentner, C., Oswald, J., Lunacek, A., Deibl, M., Bartsch, G., Radmayr, C. J. Urol. (2006) [Pubmed]
  9. Anaphylaxis to isosulfan blue and cross-reactivity to patent blue V: case report and review of the nomenclature of vital blue dyes. Scherer, K., Studer, W., Figueiredo, V., Bircher, A.J. Ann. Allergy Asthma Immunol. (2006) [Pubmed]
  10. Sentinel lymphadenectomy for staging patients with intermediate-level melanoma. Smart, K.R., Cahoon, B.W., Dale, P.S. The American surgeon. (2000) [Pubmed]
  11. Sentinel node mapping identifies vaccine-draining lymph nodes with tumor-specific immunological activity. Chin, C.S., Bear, H.D. Ann. Surg. Oncol. (2002) [Pubmed]
  12. Potential applications of intraoperative lymphatic mapping in vulvar cancer. Levenback, C., Burke, T.W., Morris, M., Malpica, A., Lucas, K.R., Gershenson, D.M. Gynecol. Oncol. (1995) [Pubmed]
  13. Sentinel lymph node mapping for adenocarcinoma of the colon does not improve staging accuracy. Read, T.E., Fleshman, J.W., Caushaj, P.F. Dis. Colon Rectum (2005) [Pubmed]
  14. Carbon dye as an adjunct to isosulfan blue dye for sentinel lymph node dissection. Lucci, A., Turner, R.R., Morton, D.L. Surgery (1999) [Pubmed]
  15. Methylene blue dye as an alternative to isosulfan blue dye for sentinel lymph node localization. Simmons, R., Thevarajah, S., Brennan, M.B., Christos, P., Osborne, M. Ann. Surg. Oncol. (2003) [Pubmed]
  16. Outcomes for patients with T1 squamous cell cancer of the vulva undergoing sentinel node biopsy. Terada, K.Y., Shimizu, D.M., Jiang, C.S., Wong, J.H. Gynecol. Oncol. (2006) [Pubmed]
  17. Sentinel node identification and the ability to detect metastatic tumor to inguinal lymph nodes in squamous cell cancer of the vulva. Moore, R.G., DePasquale, S.E., Steinhoff, M.M., Gajewski, W., Steller, M., Noto, R., Falkenberry, S. Gynecol. Oncol. (2003) [Pubmed]
  18. Use of isosulfan blue for identification of lymphatic vessels: experimental and clinical evaluation. Hirsch, J.I., Tisnado, J., Cho, S.R., Beachley, M.C. AJR. American journal of roentgenology. (1982) [Pubmed]
  19. Lymphazurin 1% versus 99mTc sulfur colloid for lymphatic mapping in colorectal tumors: a comparative analysis. Saha, S., Dan, A.G., Berman, B., Wiese, D., Schochet, E., Barber, K., Choudhri, S., Kaushal, S., Ganatra, B., Desai, D., Nagaraju, M., Mannam, S. Ann. Surg. Oncol. (2004) [Pubmed]
  20. Incidence of anaphylactoid reactions to isosulfan blue dye during breast carcinoma lymphatic mapping in patients treated with preoperative prophylaxis: results of a surgical prospective clinical practice protocol. Raut, C.P., Hunt, K.K., Akins, J.S., Daley, M.D., Ross, M.I., Singletary, S.E., Marshall, G.D., Meric-Bernstam, F., Babiera, G., Feig, B.W., Ames, F.C., Kuerer, H.M. Cancer (2005) [Pubmed]
  21. Experience with lymphatic mapping in breast cancer using isosulfan blue dye. Ratanawichitrasin, A., Levy, L., Myles, J., Crowe, J.P. Journal of women's health / the official publication of the Society for the Advancement of Women's Health Research. (1998) [Pubmed]
  22. Detection of gastric and colonic sentinel nodes through endoscopic administration of 99mTc-DTPA-mannosyl-dextran in pigs. Méndez, J., Wallace, A.M., Hoh, C.K., Vera, D.R. J. Nucl. Med. (2003) [Pubmed]
  23. Isosulfan blue affects pulse oximetry. Vokach-Brodsky, L., Jeffrey, S.S., Lemmens, H.J., Brock-Utne, J.G. Anesthesiology (2000) [Pubmed]
  24. Sentinel node biopsy using dye and isotope double tracers in early gastric cancer. Lee, J.H., Ryu, K.W., Kim, C.G., Kim, S.K., Lee, J.S., Kook, M.C., Choi, I.J., Kim, Y.W., Chang, H.J., Bae, J.M. Ann. Surg. Oncol. (2006) [Pubmed]
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