Disease relevance of MOLI001013

• Anaphylactoid reactions to isosulfan blue dye during breast cancer lymphatic mapping in patients given preoperative prophylaxis [1].
• EXPERIMENTAL DESIGN: Isosulfan blue was injected endoscopically as the dye-guided method at a submucosal lesion of early gastric cancer [2].
• The SN, which is the first node in the lymphatic basin to receive metastases from the primary tumor, was identified using isosulfan blue dye [3].
• CONCLUSIONS: In our series, the incidence of anaphylaxis to isosulfan blue was approximately 1% [4].
• This procedure identifies the SLN either visually by injecting isosulfan blue dye around the primary melanoma site or by handheld gamma probe after radiocolloid injection [4].

High impact information on MOLI001013

• Injection of isosulfan blue intradermally into the skin of the medial thigh consistently led to coloration of the central lymph node, whereas intradermal abdominal wall injections and intradermal lateral thigh injections resulted in coloration of the lateral lymph node [5].
• Because a 1% sterile solution of methylene blue used for occult breast tumor localization has been shown to interfere with the estrogen-receptor protein (ERP) binding-capacity assay, isosulfan blue in a 1% injection was studied as a potential alternate stain [6].
• Noninterference of isosulfan blue on estrogen-receptor activity [6].
• RESULTS: In patients who received isosulfan blue dye alone (n=783) or a combination of blue dye and radiocolloid (n=4192), anaphylaxis was reported in .1% of subjects (5 of 4975) [7].
• CONCLUSIONS: Microsurgical repair of varicoceles using isosulfan blue helps in identifying and preserving the lymphatic drainage [8].

Chemical compound and disease context of MOLI001013

• Anaphylaxis to isosulfan blue and cross-reactivity to patent blue V: case report and review of the nomenclature of vital blue dyes [9].
• This study is a retrospective review of patients with intermediate melanomas treated by the senior author (P.S.D.). Isosulfan blue dye and a radioactive technetium-labeled dye were used to identify the sentinel node [10].

Anatomical context of MOLI001013

• Cytosols derived from ERP-positive lyophilized powders and human breast tissue were evaluated with and without varying levels of treatment with isosulfan blue [6].
• CONCLUSION: We have shown that IB identifies immunologically active DLNs, does not interfere with expansion of lymphocytes in vitro, and, more importantly, has no detrimental effect on the ability of lymphocytes to induce tumor regression in vivo [11].
• METHODS: Isosulfan blue was injected into the dermis at the leading edge of the vulvar lesion in 21 patients [12].
• After mobilization of the colon and mesentery, 1 to 2 ml of isosulfan blue dye was injected subserosally around the tumor [13].
• Twenty-two rats underwent lymphatic mapping in each distal lower extremity with various combinations of carbon dye and isosulfan blue dye [14].

Associations of MOLI001013 with other chemical compounds

• Methylene blue dye as an alternative to isosulfan blue dye for sentinel lymph node localization [15].
• METHODS: Patients with T1 cancers underwent pre-operative lymphoscintigraphy and sentinel lymph node dissection using technetium sulfur colloid and isosulfan blue dye [16].
• Technetium-99m sulfur colloid was injected intradermally at the tumor margins 90-180 min preoperatively followed by a similar injection of isosulfan blue dye 5-10 min before the groin dissection [17].
• The suitability of isosulfan blue, the 2,5 disulfonic acid isomer of Patent Blue, for this purpose was evaluated experimentally in the rat and clinically in 11 volunteers and 543 patients under an investigational new drug application [18].

Gene context of MOLI001013

• The use of isosulfan blue for localization of occult breast tumor is suggested when an ERP binding capacity assay is anticipated [6].
• Isosulfan blue detected 152 SLNs, TSC detected 100, and both modalities detected 96 [19].
• METHODS: Ten days after vaccination with 4T07-IL-2, .1 ml of 1% IB was injected into the vaccination site (footpads or flanks) [11].
• BACKGROUND: Severe anaphylactoid reactions to isosulfan blue dye requiring resuscitation are reported to occur in 1.1% of patients with breast carcinoma undergoing sentinel lymphadenectomy [20].
• The diagnostic accuracy of the isosulfan blue dye technique for SLN biopsy, 94%, is high enough to warrant further research [21].

Analytical, diagnostic and therapeutic context of MOLI001013

• A standard endoscopic sclerotherapy needle and sheath filled with 0.9% saline was then loaded with 0.2 mL of a 7.4-MBq 1:1 (v/v) mixture of isosulfan blue and (99m)Tc-DTPA-mannosyl-dextran (7.4 MBq, 0.3 nmol) [22].
• Three cases of selective SLN dissection, in which adverse reactions to isosulfan blue occurred, were reviewed [4].
• Isosulfan blue affects pulse oximetry [23].
• After laparotomy, isosulfan blue was intraoperatively injected using an endoscope [24].
• RESULTS: We report three cases of anaphylaxis after intradermal injection with isosulfan blue of 406 patients who underwent intraoperative lymphatic mapping by using the procedure as described above [4].

References