Disease relevance of Potassium perchlorate anh

• Short term administration of potassium perchlorate restores euthyroidism in amiodarone iodine-induced hypothyroidism [1].
• Abnormal localization of 99mTc pertechnetate was detected in the choroid plexus of patients with renal insufficiency despite the administration of potassium perchlorate [2].
• Potassium perchlorate has been used at various times during the last 50 years to treat hyperthyroidism [3].
• The effect of 1000 ppm potassium perchlorate (KClO4), 1000 ppm potassium iodide (KI) or 1000 ppm propylthiouracil (PTU) in the diet on the development of thyroid tumors was studied histologically and biochemically in Wistar rats given a single ip injection of 280 mg of N-bis(2-hydroxypropyl)nitrosamine (DHPN) per 100 g body weight [4].
• However, combined therapy with methimazole and potassium perchlorate rapidly alleviated hyperthyroidism in almost all patients with goiter [5].

High impact information on Potassium perchlorate anh

• To evaluate the function of hNIS, the inhibition study was examined with 1 mmol/L potassium perchlorate [6].
• Type I patients, given methimazole (30 mg/day) and potassium perchlorate (1 g/day), achieved normal free T3 and IL-6 concentrations after an average of 4 weeks [7].
• Iodine kinetic analysis after the ingestion of potassium perchlorate and methimazole was compatible with a leak of nonhormonal iodide from the thyroid [8].
• Uptake of MIBI by choroid plexus occurred despite pretreatment with potassium perchlorate (6 mg/kg) and complicated interpretation of deep/paraventricular lesions [9].
• The increased localization of 99mTc pertechnetate could not be related to high blood levels of radioactivity, altered protein binding, increased erythrocyte labeling or to impaired gastrointestinal absorption of potassium perchlorate [2].

Chemical compound and disease context of Potassium perchlorate anh

• Two patients with amiodarone-induced thyrotoxicosis were treated successfully with potassium perchlorate and carbimazole while treatment with amiodarone was continued [10].

Biological context of Potassium perchlorate anh

• Pharmacokinetics of pertechnetate administered after pretreatment with 400 mg of potassium perchlorate: concise communication [11].

Anatomical context of Potassium perchlorate anh

• Suppression of thyroid function by potassium perchlorate (KClO4) drastically reduces Harderian gland weight in both males and females [12].
• Repeated Tc-99m pertechnetate scintigraphy performed after oral administration of potassium perchlorate (KCLO4) revealed complete disappearance of the radioactive accumulation in the mediastinum, suggesting that the retrotracheal mass was a retrosternal goiter [13].

Associations of Potassium perchlorate anh with other chemical compounds

• Treatment of AIH consists of levothyroxine replacement therapy while continuing amiodarone therapy; alternatively, amiodarone can be discontinued, if possible, and the natural course toward euthyroidism can be accelerated by a short trial of potassium perchlorate [14].
• The concentrations of 36Cl-labeled potassium perchlorate (K36CiO4) and previously reported iodide (131I) in the ova, thyroid gland, and blood of the laying hen were compared in this investigation [15].
• Biological damage in spleen by iodine-125 in potassium perchlorate blocked thyroid of rats [16].
• Fourier transform infrared spectra of MnO4- anions isomorphously isolated in potassium perchlorate matrices were recorded at room and low temperature (LT, approximately 100 K) [17].
• We set up a modified technetium-99m (Tc-99m) pertechnetate/Tc-99m MIBI (Tc-MIBI) subtraction scintigraphy for parathyroid imaging by introducing the use of potassium perchlorate (KCLO4) [18].

Gene context of Potassium perchlorate anh

• Management differs in the two forms of AIT, since Type 1 usually responds to combined thionamides and potassium perchlorate therapy, while Type 2 is generally responsive to glucocorticoids [19].

Analytical, diagnostic and therapeutic context of Potassium perchlorate anh

• In addition, premedication of three patients with 200 mg of potassium-perchlorate did not block this neck uptake [20].
• We used a modified 99mTcO4/MIBI scintigraphic procedure which included the oral administration of potassium perchlorate to cause rapid 99mTcO4 washout from the thyroid tissue, thereby permitting the acquisition of high-quality early MIBI images [21].
• Administration of potassium perchlorate to improve the quality of gated blood pool imaging [22].
• Tc-99m pertechnetate scintigraphy before and after potassium perchlorate administration for the diagnosis of retrosternal goiter [13].

References