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Gene Review

Mbp  -  myelin basic protein

Rattus norvegicus

Synonyms: MBP, Myelin basic protein
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Disease relevance of Mbp


Psychiatry related information on Mbp

  • If similar inappropriate excitations are also triggered by those immunogens specifically associated with Alzheimer's disease (beta-amyloid), AIDS dementia (gp120 and gp41), or multiple sclerosis (myelin basic protein), they might explain some of the acute, transient neurological and psychiatric symptoms associated with these disorders [6].

High impact information on Mbp


Chemical compound and disease context of Mbp


Biological context of Mbp


Anatomical context of Mbp


Associations of Mbp with chemical compounds


Physical interactions of Mbp


Enzymatic interactions of Mbp

  • The activation of ERK2 was determined by immunoblotting and measurement of the activity in terms of the phosphorylating activity of immunoprecipitates with MAPK antibody on myelin basic protein [24].
  • In the present study, immunoprecipitates of Trk NGF receptors from PC12 cells (+/- NGF treatment) were assayed for protein kinase activity by using the substrates myelin basic protein and histone HF1 under phosphorylating conditions optimal for protein kinase N and in the presence or absence of purine analogs [25].

Regulatory relationships of Mbp


Other interactions of Mbp


Analytical, diagnostic and therapeutic context of Mbp


  1. Characterization of cloned cDNA representing rat myelin basic protein: absence of expression in brain of shiverer mutant mice. Roach, A., Boylan, K., Horvath, S., Prusiner, S.B., Hood, L.E. Cell (1983) [Pubmed]
  2. A comparative study of experimental autoimmune encephalomyelitis in Lewis and DA rats. Stepaniak, J.A., Gould, K.E., Sun, D., Swanborg, R.H. J. Immunol. (1995) [Pubmed]
  3. Myelination delay in the cerebral white matter of immature rats with kaolin-induced hydrocephalus is reversible. Del Bigio, M.R., Kanfer, J.N., Zhang, Y.W. J. Neuropathol. Exp. Neurol. (1997) [Pubmed]
  4. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. V. Hierarchy of suppression by myelin basic protein from different species. Miller, A., Lider, O., al-Sabbagh, A., Weiner, H.L. J. Neuroimmunol. (1992) [Pubmed]
  5. Selective effect of hypothyroidism on expression of myelin markers during development. Barradas, P.C., Vieira, R.S., De Freitas, M.S. J. Neurosci. Res. (2001) [Pubmed]
  6. The bacterial endotoxin lipopolysaccharide causes rapid inappropriate excitation in rat cortex. Wang, Y.S., White, T.D. J. Neurochem. (1999) [Pubmed]
  7. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Moalem, G., Leibowitz-Amit, R., Yoles, E., Mor, F., Cohen, I.R., Schwartz, M. Nat. Med. (1999) [Pubmed]
  8. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Waisman, A., Ruiz, P.J., Hirschberg, D.L., Gelman, A., Oksenberg, J.R., Brocke, S., Mor, F., Cohen, I.R., Steinman, L. Nat. Med. (1996) [Pubmed]
  9. Usefulness of a mouse myelin basic protein promoter for gene therapy of malignant glioma: myelin basic protein promoter is strongly active in human malignant glioma cells. Miyao, Y., Shimizu, K., Tamura, M., Akita, H., Ikeda, K., Mabuchi, E., Kishima, H., Hayakawa, T., Ikenaka, K. Jpn. J. Cancer Res. (1997) [Pubmed]
  10. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. Khoury, S.J., Hancock, W.W., Weiner, H.L. J. Exp. Med. (1992) [Pubmed]
  11. Accelerated response to reinoculation in experimental allergic encephalomyelitis: histopathologic study. Levine, S., Saltzman, A. J. Neuropathol. Exp. Neurol. (1991) [Pubmed]
  12. A novel cyclic AMP response element, CACTTGATC, mediates forskolin induction of the myelin basic protein promoter in the rat Schwannoma line, D6P2T. Li, X., Wrabetz, L., Cheng, Y., Kamholz, J. J. Neurochem. (1994) [Pubmed]
  13. Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide--mechanisms independent of pyrimidine depletion. Korn, T., Magnus, T., Toyka, K., Jung, S. J. Leukoc. Biol. (2004) [Pubmed]
  14. Cloned proteolipid protein and myelin basic protein cDNA. Transcription of the two genes during myelination. Schaich, M., Budzinski, R.M., Stoffel, W. Biol. Chem. Hoppe-Seyler (1986) [Pubmed]
  15. Evidence that the homeodomain protein Gtx is involved in the regulation of oligodendrocyte myelination. Awatramani, R., Scherer, S., Grinspan, J., Collarini, E., Skoff, R., O'Hagan, D., Garbern, J., Kamholz, J. J. Neurosci. (1997) [Pubmed]
  16. Enhanced degradation of messenger RNA encoding myelin proteins by terminal complement complexes in oligodendrocytes. Shirazi, Y., Rus, H.G., Macklin, W.B., Shin, M.L. J. Immunol. (1993) [Pubmed]
  17. Conduction abnormalities are restricted to the central nervous system in experimental autoimmune encephalomyelitis induced by inoculation with proteolipid protein but not with myelin basic protein. Chalk, J.B., McCombe, P.A., Pender, M.P. Brain (1994) [Pubmed]
  18. Endoplasmic reticulum stress in PLP-overexpressing transgenic rats: gray matter oligodendrocytes are more vulnerable than white matter oligodendrocytes. Bauer, J., Bradl, M., Klein, M., Leisser, M., Deckwerth, T.L., Wekerle, H., Lassmann, H. J. Neuropathol. Exp. Neurol. (2002) [Pubmed]
  19. Differential ultrastructural localization of myelin basic protein, myelin/oligodendroglial glycoprotein, and 2',3'-cyclic nucleotide 3'-phosphodiesterase in the CNS of adult rats. Brunner, C., Lassmann, H., Waehneldt, T.V., Matthieu, J.M., Linington, C. J. Neurochem. (1989) [Pubmed]
  20. Effect of cyclic AMP on the expression of myelin basic protein species and myelin proteolipid protein in committed oligodendrocytes: differential involvement of the transcription factor CREB. Afshari, F.S., Chu, A.K., Sato-Bigbee, C. J. Neurosci. Res. (2001) [Pubmed]
  21. Co-clustering of galactosylceramide and membrane proteins in oligodendrocyte membranes on interaction with polyvalent carbohydrate and prevention by an intact cytoskeleton. Boggs, J.M., Wang, H. J. Neurosci. Res. (2004) [Pubmed]
  22. Effects of dexamethasone on the expression of myelin basic protein, proteolipid protein, and glial fibrillary acidic protein genes in developing rat brain. Tsuneishi, S., Takada, S., Motoike, T., Ohashi, T., Sano, K., Nakamura, H. Brain Res. Dev. Brain Res. (1991) [Pubmed]
  23. Stage-specific expression of myelin basic protein in oligodendrocytes involves Nkx2.2-mediated repression that is relieved by the Sp1 transcription factor. Wei, Q., Miskimins, W.K., Miskimins, R. J. Biol. Chem. (2005) [Pubmed]
  24. Pituitary adenylate cyclase activating polypeptide (PACAP) stimulates mitogen-activated protein kinase (MAPK) in cultured rat astrocytes. Moroo, I., Tatsuno, I., Uchida, D., Tanaka, T., Saito, J., Saito, Y., Hirai, A. Brain Res. (1998) [Pubmed]
  25. A purine analog-sensitive protein kinase activity associates with Trk nerve growth factor receptors. Volonté, C., Loeb, D.M., Greene, L.A. J. Neurochem. (1993) [Pubmed]
  26. An alpha-chain TCR CDR3 peptide can enhance EAE induced by myelin basic protein or proteolipid protein. Yamamura, T., Geng, T.C., Kozovska, M.F., Yokoyama, K., Cohen, I.R., Tabira, T. J. Neurosci. Res. (1996) [Pubmed]
  27. Basic fibroblast growth factor down-regulates myelin basic protein gene expression and alters myelin compaction of mature oligodendrocytes in vitro. Fressinaud, C., Vallat, J.M., Labourdette, G. J. Neurosci. Res. (1995) [Pubmed]
  28. Autoimmune demyelination in the central nervous system. Tabira, T. Ann. N. Y. Acad. Sci. (1988) [Pubmed]
  29. A rat G protein-coupled receptor selectively expressed in myelin-forming cells. Allard, J., Barrón, S., Diaz, J., Lubetzki, C., Zalc, B., Schwartz, J.C., Sokoloff, P. Eur. J. Neurosci. (1998) [Pubmed]
  30. Calpain inhibitor prevented apoptosis and maintained transcription of proteolipid protein and myelin basic protein genes in rat spinal cord injury. Ray, S.K., Matzelle, D.D., Sribnick, E.A., Guyton, M.K., Wingrave, J.M., Banik, N.L. J. Chem. Neuroanat. (2003) [Pubmed]
  31. Molecular and developmental characterization of novel cDNAs of the myelin-associated/oligodendrocytic basic protein. Holz, A., Schaeren-Wiemers, N., Schaefer, C., Pott, U., Colello, R.J., Schwab, M.E. J. Neurosci. (1996) [Pubmed]
  32. Maturation-dependent apoptotic cell death of oligodendrocytes in myelin-deficient rats. Grinspan, J.B., Coulalaglou, M., Beesley, J.S., Carpio, D.F., Scherer, S.S. J. Neurosci. Res. (1998) [Pubmed]
  33. Transferrin is an essential factor for myelination. Espinosa de los Monteros, A., Kumar, S., Zhao, P., Huang, C.J., Nazarian, R., Pan, T., Scully, S., Chang, R., de Vellis, J. Neurochem. Res. (1999) [Pubmed]
  34. Intracellular distribution of myelin protein gene products is altered in oligodendrocytes of the taiep rat. O'Connor, L.T., Goetz, B.D., Couve, E., Song, J., Duncan, I.D. Mol. Cell. Neurosci. (2000) [Pubmed]
  35. Triiodothyronine has diverse and multiple stimulating effects on expression of the major myelin protein genes. Tosic, M., Torch, S., Comte, V., Dolivo, M., Honegger, P., Matthieu, J.M. J. Neurochem. (1992) [Pubmed]
  36. Active and passive experimental autoimmune encephalomyelitis in strain 129/J (H-2b) mice. Fritz, R.B., Zhao, M.L. J. Neurosci. Res. (1996) [Pubmed]
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