The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Osthole     7-methoxy-8-(3-methylbut-2- enyl)chromen-2-one

Synonyms: Osthol, Ostole, Ostol, CHEMBL52229, S2337_Selleck, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Osthole


High impact information on Osthole


Chemical compound and disease context of Osthole


Biological context of Osthole


Anatomical context of Osthole

  • By means of alkaline phosphatase (ALP) activity, osteocalcin, osteopontin, and type I collagen, enzyme-linked immunosorbent assay, we have shown that osthole exhibits a significant induction of differentiation in two human osteoblast-like cell lines, MG-63 and hFOB [6].
  • CONCLUSION: The data suggested that osthole possesses a relaxant effect on rabbit corpus cavernosal tissues which is attributable to the release of NO from sinusoidal endothelium and to the potentiation of the cGMP and/or cAMP signal mediating relaxation of cavernosal smooth muscle by inhibiting phosphodiesterase [10].
  • These data suggest that BMP-2/p38 pathway links to the early phase, whereas ERK1/2 pathway is associated with the later phase in osthole-mediated differentiation of osteoblast cells [6].
  • However, the addition of osthole (up to 10(-4)M) to a liver cytosol fraction isolated from mice treated with anti-Fas antibody did not inhibit caspase-3 activity in vitro [7].
  • The antiproliferative effect of osthole on rat vascular smooth muscle cells was examined in this study [8].

Associations of Osthole with other chemical compounds

  • The coumarin osthol attenuates the binding of thyrotropin-releasing hormone in rat pituitary GH4C1 cells [11].
  • Bioassay-directed fractionation led to the identification of four known coumarins, osthole (1), imperatorin (2), xanthotoxin (3), and isopimpinellin (4), from the ethanolic extract of the fruit of Cnidium monnieri (L.) Cusson [12].
  • RESULTS: After treatment with osthole the levels of serum total cholesterol (TC), triglyceride (TG), lower density lipoprotein-cholesterol (LDL-C), coefficient of hepatic weight, and the hepatic tissue contents of TC and TG were significantly decreased [3].
  • From the leaves of Phellolophium madagascariense Baker (Apiaceae), an endemic herb to Madagascar, three known coumarins (osthol, murraol and meranzin hydrate) have been isolated and identified [13].
  • Single administration of osthol did not inhibit SP-induced scratching, and imperatorin very weakly subsided scratching [14].

Gene context of Osthole

  • Thus, treatment of mice with osthole inhibited caspase-3 activity by an effect upstream of caspase-3 activation [7].
  • In contrast, the production of osteocalcin induced by osthole was inhibited by the mitogen-activated protein kinase kinase inhibitor PD98059 (2'-amino-3'-methoxyflavone) or by expression of an ERK2 siRNA [6].
  • The present results show that osthole prevented anti-Fas antibody-induced hepatitis by inhibiting the Fas-mediated apoptotic pathway [7].
  • Pretreatment of mice with osthole (10, 50, and 100 mg/kg, i.p.) prevented the elevation of plasma alanine aminotransferase (ALT) caused by anti-Fas antibody (175 microg/kg, i.v.). Administration of osthole to mice even at a dose of 10 mg/kg significantly inhibited of anti-Fas antibody-induced elevation of plasma ALT [7].
  • The results show that osthol modulates TRH-evoked responses by interacting with the TRH receptor [11].

Analytical, diagnostic and therapeutic context of Osthole


  1. Osthole increases glycosylation of hepatitis B surface antigen and suppresses the secretion of hepatitis B virus in vitro. Huang, R.L., Chen, C.C., Huang, Y.L., Hsieh, D.J., Hu, C.P., Chen, C.F., Chang, C. Hepatology (1996) [Pubmed]
  2. Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells. Wu, S.N., Lo, Y.K., Chen, C.C., Li, H.F., Chiang, H.T. Biochem. Pharmacol. (2002) [Pubmed]
  3. Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals. Song, F., Xie, M.L., Zhu, L.J., Zhang, K.P., Xue, J., Gu, Z.L. World J. Gastroenterol. (2006) [Pubmed]
  4. Effects of osthole on postmenopausal osteoporosis using ovariectomized rats; comparison to the effects of estradiol. Li, X.X., Hara, I., Matsumiya, T. Biol. Pharm. Bull. (2002) [Pubmed]
  5. Inhibition of platelet thromboxane formation and phosphoinositides breakdown by osthole from Angelica pubescens. Ko, F.N., Wu, T.S., Liou, M.J., Huang, T.F., Teng, C.M. Thromb. Haemost. (1989) [Pubmed]
  6. Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells. Kuo, P.L., Hsu, Y.L., Chang, C.H., Chang, J.K. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  7. Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway. Okamoto, T., Kawasaki, T., Hino, O. Biochem. Pharmacol. (2003) [Pubmed]
  8. Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens. Guh, J.H., Yu, S.M., Ko, F.N., Wu, T.S., Teng, C.M. Eur. J. Pharmacol. (1996) [Pubmed]
  9. Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens. Ko, F.N., Wu, T.S., Liou, M.J., Huang, T.F., Teng, C.M. Eur. J. Pharmacol. (1992) [Pubmed]
  10. Effect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue in vitro. Chen, J., Chiou, W.F., Chen, C.C., Chen, C.F. J. Urol. (2000) [Pubmed]
  11. The coumarin osthol attenuates the binding of thyrotropin-releasing hormone in rat pituitary GH4C1 cells. Ojala, T., Vuorela, P., Vuorela, H., Törnquist, K. Planta Med. (2001) [Pubmed]
  12. Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum. Chiou, W.F., Huang, Y.L., Chen, C.F., Chen, C.C. Planta Med. (2001) [Pubmed]
  13. Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker. Riviere, C., Goossens, L., Pommery, N., Fourneau, C., Delelis, A., Henichart, J.P. Nat. Prod. Res. (2006) [Pubmed]
  14. Inhibition of itch-scratch response by fruits of Cnidium monnieri in mice. Basnet, P., Yasuda, I., Kumagai, N., Tohda, C., Nojima, H., Kuraishi, Y., Komatsu, K. Biol. Pharm. Bull. (2001) [Pubmed]
  15. Pharmacokinetics of osthole in rat plasma using high-performance liquid chromatography. Tsai, T.H., Tsai, T.R., Chen, C.C., Chen, C.F. Journal of pharmaceutical and biomedical analysis. (1996) [Pubmed]
  16. Chemical aspects of coumarin compounds for the prevention of hepatocellular carcinomas. Okamoto, T., Kobayashi, T., Yoshida, S. Current medicinal chemistry. Anti-cancer agents. (2005) [Pubmed]
WikiGenes - Universities