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Chemical Compound Review

AC1NWAOO     2,3-dihydroxybutanedioic acid; 1-[4-(2...

Synonyms: SureCN41105, CHEMBL1256957, BSPBio_002029, KBioGR_000557, KBioSS_001441, ...
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Disease relevance of Metoprolol tartrate


High impact information on Metoprolol tartrate

  • Influence of heart rate, blood pressure, and beta-blocker dose on outcome and the differences in outcome between carvedilol and metoprolol tartrate in patients with chronic heart failure: results from the COMET trial [5].
  • To evaluate the effect of beta blockade on energy metabolism in ischaemic myocardium metoprolol tartrate in doses of 0.2 or 0.5 or saline was injected into 24 anaesthetised dogs 20 min after coronary ligation [6].
  • The pharmacokinetics of metoprolol have been studied in a group of patients with varying degrees of renal impairment and in healthy subjects after administration of 20 mg of metoprolol tartrate intravenously and 50 mg orally in a single dose and during steady-state conditions [7].
  • Therefore we analyzed 24-h ECG Holter recordings from a study which compared the long-term clinical efficacy of metoprolol tartrate to carvedilol in chronic heart failure patients using the same dosing regimen as in COMET [8].
  • BACKGROUND: The Carvedilol or Metoprolol European Trial (COMET) reported a significant survival benefit for carvedilol, a beta1-, beta2- and alpha1-blocker, vs. metoprolol tartrate, a beta1-selective blocker, in patients with mild-to-severe chronic heart failure (CHF) [9].

Chemical compound and disease context of Metoprolol tartrate


Biological context of Metoprolol tartrate

  • 2. Concomitant treatment with metoprolol tartrate (2.5 mg/kg, intraperitoneally, twice daily) prevented the elevation in blood pressure induced by adrenaline from osmotic minipumps [13].
  • Chemsimul was used to solve the decay kinetics of transients and to simulate the radiolysis of metoprolol tartrate solutions [14].
  • This study was undertaken to find out if early postoperative high-dose infusion of the selective beta 1-blocking agent metoprolol tartrate has additional effects on metabolic variables related to myocardial energy supply/demand balance compared with those obtained with a late preoperative oral dose [15].
  • The delayed T(max) lower C(max) decreased K(a) unaltered bioavailability and prolonged t(1/2) indicated a slow and prolonged release of metoprolol tartrate from guar gum three-layer matrix tablets in comparison with the immediate release tablet dosage form [16].
  • The in vivo biotransformation of metoprolol tartrate in the thoroughbred racehorse was studied after administration of a single oral dose [17].

Anatomical context of Metoprolol tartrate

  • Twenty patients undergoing elective coronary artery bypass surgery were matched in two groups and given either metoprolol tartrate (0.03 mg/kg) or pindolol (0.003 mg/kg) intravenously during recovery from surgery [18].
  • The distribution of metoprolol tartrate (MPL) into the brain and cerebrospinal fluid (CSF) from plasma was determined at 2 different steady-state plasma concentrations (2 and 20 nmol/ml) and following intravenous bolus administration (100 nmol/kg) in rats [19].

Associations of Metoprolol tartrate with other chemical compounds


Gene context of Metoprolol tartrate


Analytical, diagnostic and therapeutic context of Metoprolol tartrate


  1. Metoprolol tartrate for essential tremor. Riley, T., Pleet, A.B. N. Engl. J. Med. (1979) [Pubmed]
  2. Hemodynamic comparison of twice daily metoprolol tartrate with once daily metoprolol succinate in congestive heart failure. Kukin, M.L., Mannino, M.M., Freudenberger, R.S., Kalman, J., Buchholz-Varley, C., Ocampo, O. J. Am. Coll. Cardiol. (2000) [Pubmed]
  3. Metoprolol responding uveitis. Kassif, Y., Rehany, U., Rumelt, S. Eye (London, England) (2004) [Pubmed]
  4. A fixed combination of metoprolol and chlorthalidone in hypertension. A clinical trial in general practice. Govind, U., Munro, B.F., Robertson, L.I. S. Afr. Med. J. (1981) [Pubmed]
  5. Influence of heart rate, blood pressure, and beta-blocker dose on outcome and the differences in outcome between carvedilol and metoprolol tartrate in patients with chronic heart failure: results from the COMET trial. Metra, M., Torp-Pedersen, C., Swedberg, K., Cleland, J.G., Di Lenarda, A., Komajda, M., Remme, W.J., Lutiger, B., Scherhag, A., Lukas, M.A., Charlesworth, A., Poole-Wilson, P.A. Eur. Heart J. (2005) [Pubmed]
  6. Evaluation of the effect of metoprolol on energy metabolism in the ischaemic myocardium in relation to regional myocardial blood flow. Nanki, M., Itoh, K., Matsubara, T., Nishimura, K., Kambe, T., Sugiyama, S., Ozawa, T., Sakamoto, N. Cardiovasc. Res. (1987) [Pubmed]
  7. Pharmacokinetic and pharmacodynamic properties of metoprolol in patients with impaired renal function. Jordö, L., Attman, P.O., Aurell, M., Johansson, L., Johnsson, G., Regårdh, C.G. Clinical pharmacokinetics. (1980) [Pubmed]
  8. Do metoprolol and carvedilol have equivalent effects on diurnal heart rate in patients with chronic heart failure? Sanderson, J.E., Leung, L.Y., Chan, S.K., Yip, G.W., Fung, J.W., Yu, C.M. Eur. J. Heart Fail. (2005) [Pubmed]
  9. Exchange of beta-blockers in heart failure patients. Experiences from the poststudy phase of COMET (the Carvedilol or Metoprolol European Trial). Di Lenarda, A., Remme, W.J., Charlesworth, A., Cleland, J.G., Lutiger, B., Metra, M., Komajda, M., Torp-Pedersen, C., Scherhag, A., Swedberg, K., Poole-Wilson, P.A. Eur. J. Heart Fail. (2005) [Pubmed]
  10. Metoprolol in essential tremor. Newman, R.P., Jacobs, L. Arch. Neurol. (1980) [Pubmed]
  11. Randomized, Double-Blind Comparison of Acute beta1-Blockade With 50 mg Metoprolol Tartrate vs 25 mg Carvedilol in Normal Subjects. Billeh, R., Hirsh, D., Barker, C., Jorgensen, B., Jeger, R., Ramanathan, K., Tseng, C.H., Hudaihed, A., Haas, F., Jorde, U.P. Congestive heart failure (Greenwich, Conn.) (2006) [Pubmed]
  12. Differential effects of beta-blockers on albuminuria in patients with type 2 diabetes. Bakris, G.L., Fonseca, V., Katholi, R.E., McGill, J.B., Messerli, F., Phillips, R.A., Raskin, P., Wright, J.T., Waterhouse, B., Lukas, M.A., Anderson, K.M., Bell, D.S. Hypertension (2005) [Pubmed]
  13. Adrenaline-induced hypertension in rats. Tung, L.H., Rand, M.J., Majewski, H. Clin. Sci. (1981) [Pubmed]
  14. Radical mechanisms in the radiosterilization of metoprolol tartrate solutions. Slegers, C., Baldacchino, G., Le Parc, D., Hickel, B., Tilquin, B. Pharm. Res. (2003) [Pubmed]
  15. Influence of beta 1-blockade on myocardial substrates early after a coronary operation. Wesslén, O., van der Linden, J., Ekroth, R., Joachimsson, P.O., Nordgren, L., Nyström, S.O., Ronquist, G., Tydén, H. Ann. Thorac. Surg. (1992) [Pubmed]
  16. Pharmacokinetic evaluation of guar gum-based three-layer matrix tablets for oral controlled delivery of highly soluble metoprolol tartrate as a model drug. Al-Saidan, S.M., Krishnaiah, Y.S., Satyanarayana, V., Bhaskar, P., Karthikeyan, R.S. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. (2004) [Pubmed]
  17. In vivo biotransformation of metoprolol in the horse and on-column esterification of the aminocarboxylic acid metabolite by alcohols during solid phase extraction using mixed mode columns. Dumasia, M.C. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
  18. Hemodynamic responses to beta-adrenergic blockade with metoprolol and pindolol after coronary artery bypass surgery. Salmenperä, M., Yrjölä, H., Heikkilä, J. Chest (1983) [Pubmed]
  19. Brain and cerebrospinal fluid distributions of metoprolol in rats. Nakazono, T., Murakami, T., Sakai, S., Higashi, Y., Yata, N. J. Pharmacobio-dyn. (1992) [Pubmed]
  20. Lipolysis in burned patients is stimulated by the beta 2-receptor for catecholamines. Herndon, D.N., Nguyen, T.T., Wolfe, R.R., Maggi, S.P., Biolo, G., Muller, M., Barrow, R.E. Archives of surgery (Chicago, Ill. : 1960) (1994) [Pubmed]
  21. Utility of a one-point (3-hour postdose) plasma metabolic ratio as a phenotyping test using metoprolol in two east Asian populations. Sohn, D.R., Kusaka, M., Shin, S.G., Jang, I.J., Chiba, K., Ishizaki, T. Therapeutic drug monitoring. (1992) [Pubmed]
  22. Chronotropic incompetence as a predictor of death among patients with normal electrograms taking beta blockers (metoprolol or atenolol). Khan, M.N., Pothier, C.E., Lauer, M.S. Am. J. Cardiol. (2005) [Pubmed]
  23. Detection of myocardial bridging with ECG-gated MDCT and multiplanar reconstruction. Kantarci, M., Duran, C., Durur, I., Alper, F., Onbas, O., Gulbaran, M., Okur, A. AJR. American journal of roentgenology. (2006) [Pubmed]
  24. Beta 2- but not beta 1-adrenoceptors are involved in desipramine enhancement of aggressive behavior in long-term isolated mice. Matsumoto, K., Ojima, K., Ohta, H., Watanabe, H. Pharmacol. Biochem. Behav. (1994) [Pubmed]
  25. Stability and activity of alteplase with injectable drugs commonly used in cardiac therapy. Lam, X.M., Ward, C.A., du Mée, C.P. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. (1995) [Pubmed]
  26. Reversible myocardial damage in gerbil brain ischaemia and its prevention by beta-adrenergic blockade. Kolin, A., Brezina, A., Kellen, J.A., Lewis, A.J., Norris, J.W. British journal of experimental pathology. (1988) [Pubmed]
  27. Indirect blood pressure and heart rate measured quickly without observer bias using a semi-automatic machine (auto-manometer)--response to isometric exercise in normal healthy males and its modification by beta-adrenoceptor blockade. Nyberg, G. British journal of clinical pharmacology. (1977) [Pubmed]
  28. A three-layer guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate. Krishnaiah, Y.S., Karthikeyan, R.S., Satyanarayana, V. International journal of pharmaceutics. (2002) [Pubmed]
  29. Influence of smoking and gender on the disposition kinetics of metoprolol. Schaaf, L.J., Campbell, S.C., Mayersohn, M.B., Vagedes, T., Perrier, D.G. Eur. J. Clin. Pharmacol. (1987) [Pubmed]
  30. Sodium alginate microspheres of metoprolol tartrate for intranasal systemic delivery: development and evaluation. Rajinikanth, P.S., Sankar, C., Mishra, B. Drug delivery. (2003) [Pubmed]
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