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Gene Review

Adrb2  -  adrenergic receptor, beta 2

Mus musculus

Synonyms: Adrb-2, Adrb2r, Badm, Beta-2 adrenergic receptor, Beta-2 adrenoceptor, ...
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Disease relevance of Adrb2


High impact information on Adrb2


Chemical compound and disease context of Adrb2


Biological context of Adrb2


Anatomical context of Adrb2


Associations of Adrb2 with chemical compounds


Physical interactions of Adrb2


Regulatory relationships of Adrb2


Other interactions of Adrb2

  • These findings occur despite persistent cardiac beta 2-AR expression, demonstrating the importance of beta 1-ARs for proper mouse development and cardiac function, while highlighting functional differences between beta-AR subtypes [30].
  • Reverse transcriptase-PCR analysis showed that, in contrast to its dramatic down-regulatory effect on beta 3-AR mRNA, insulin did not modify the levels of beta 1- and beta 2-AR transcripts [31].
  • That bone resorption cannot increase in gonadectomized Adrb2-deficient mice highlights the biological importance of this regulation, but also contrasts sharply with the increase in bone resorption characterizing another hypogonadic mouse with low sympathetic tone, the ob/ob mouse [1].
  • Using RT-PCR, we showed that beta 2-adrenoceptor is transcribed not only at blastocyst stage but also at earlier stages of preimplantation development as well as in oocytes [16].
  • We found that in Src-deficient cells the beta2-adrenergic receptor could activate the MAPK pathway [32].

Analytical, diagnostic and therapeutic context of Adrb2


  1. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Elefteriou, F., Ahn, J.D., Takeda, S., Starbuck, M., Yang, X., Liu, X., Kondo, H., Richards, W.G., Bannon, T.W., Noda, M., Clement, K., Vaisse, C., Karsenty, G. Nature (2005) [Pubmed]
  2. Adrenergic regulation of cardiac myocyte apoptosis. Singh, K., Xiao, L., Remondino, A., Sawyer, D.B., Colucci, W.S. J. Cell. Physiol. (2001) [Pubmed]
  3. Activation of a beta 2-adrenergic receptor/Gs alpha fusion protein elicits a desensitization-resistant cAMP signal capable of inhibiting proliferation of two cancer cell lines. Bertin, B., Jockers, R., Strosberg, A.D., Marullo, S. Recept. Channels (1997) [Pubmed]
  4. Adenovirus-mediated gene transfer of the beta2-adrenergic receptor to donor hearts enhances cardiac function. Kypson, A., Hendrickson, S., Akhter, S., Wilson, K., McDonald, P., Lilly, R., Dolber, P., Glower, D., Lefkowitz, R., Koch, W. Gene Ther. (1999) [Pubmed]
  5. Axon guidance of mouse olfactory sensory neurons by odorant receptors and the beta2 adrenergic receptor. Feinstein, P., Bozza, T., Rodriguez, I., Vassalli, A., Mombaerts, P. Cell (2004) [Pubmed]
  6. Cloning and expression of a rat D2 dopamine receptor cDNA. Bunzow, J.R., Van Tol, H.H., Grandy, D.K., Albert, P., Salon, J., Christie, M., Machida, C.A., Neve, K.A., Civelli, O. Nature (1988) [Pubmed]
  7. Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein. Rockman, H.A., Hamilton, R.A., Jones, L.R., Milano, C.A., Mao, L., Lefkowitz, R.J. J. Clin. Invest. (1996) [Pubmed]
  8. Isoproterenol response following transfection of the mouse beta 2-adrenergic receptor gene into Y1 cells. Allen, J.M., Baetge, E.E., Abrass, I.B., Palmiter, R.D. EMBO J. (1988) [Pubmed]
  9. Beta-adrenergic receptors and angiotensinogen gene expression in mouse hepatoma cells in vitro. Ming, M., Wu, J., Lachance, S., Delalandre, A., Carrière, S., Chan, J.S. Hypertension (1995) [Pubmed]
  10. Antiinflammatory effects of salmeterol after inhalation of lipopolysaccharide by healthy volunteers. Maris, N.A., de Vos, A.F., Dessing, M.C., Spek, C.A., Lutter, R., Jansen, H.M., van der Zee, J.S., Bresser, P., van der Poll, T. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  11. Myocardial beta-receptor and cardiac angiotensin alterations during the acute and chronic phases of viral myocarditis. Kanda, T., Adachi, H., Ohno, T., Suzuki, T., Murata, K. Eur. Heart J. (1994) [Pubmed]
  12. Evidence for activation by beta2-adrenergic receptors of adenosine 3',5'-monophosphate formation in Ehrlich ascites tumor cells. Onaya, T., Akasu, F., Takazawa, K., Hashizume, K. Endocrinology (1978) [Pubmed]
  13. Skeletal muscle hypertrophy and anti-atrophy effects of clenbuterol are mediated by the beta2-adrenergic receptor. Hinkle, R.T., Hodge, K.M., Cody, D.B., Sheldon, R.J., Kobilka, B.K., Isfort, R.J. Muscle Nerve (2002) [Pubmed]
  14. Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes. Hupfeld, C.J., Dalle, S., Olefsky, J.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  15. Targeted disruption of the beta2 adrenergic receptor gene. Chruscinski, A.J., Rohrer, D.K., Schauble, E., Desai, K.H., Bernstein, D., Kobilka, B.K. J. Biol. Chem. (1999) [Pubmed]
  16. Expression of beta adrenergic receptors in mouse oocytes and preimplantation embryos. Cikos, S., Veselá, J., Il'ková, G., Rehák, P., Czikková, S., Koppel, J. Mol. Reprod. Dev. (2005) [Pubmed]
  17. Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes. Boivin, B., Lavoie, C., Vaniotis, G., Baragli, A., Villeneuve, L.R., Ethier, N., Trieu, P., Allen, B.G., Hébert, T.E. Cardiovasc. Res. (2006) [Pubmed]
  18. Differential cardiotoxic/cardioprotective effects of beta-adrenergic receptor subtypes in myocytes and fibroblasts in doxorubicin cardiomyopathy. Fajardo, G., Zhao, M., Powers, J., Bernstein, D. J. Mol. Cell. Cardiol. (2006) [Pubmed]
  19. Distribution of adrenergic receptors in the enteric nervous system of the guinea pig, mouse, and rat. Nasser, Y., Ho, W., Sharkey, K.A. J. Comp. Neurol. (2006) [Pubmed]
  20. Differential regulation of beta 1- and beta 2-adrenergic receptor protein and mRNA levels by glucocorticoids during 3T3-F442A adipose differentiation. Fève, B., Emorine, L.J., Briend-Sutren, M.M., Lasnier, F., Strosberg, A.D., Pairault, J. J. Biol. Chem. (1990) [Pubmed]
  21. Impaired expression and functional activity of the beta 3- and beta 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. Collins, S., Daniel, K.W., Rohlfs, E.M., Ramkumar, V., Taylor, I.L., Gettys, T.W. Mol. Endocrinol. (1994) [Pubmed]
  22. Transcriptional modulation by n-butyric acid of beta 1-, beta 2-, and beta 3-adrenergic receptor balance in 3T3-F442A adipocytes. Krief, S., Fève, B., Baude, B., Zilberfarb, V., Strosberg, A.D., Pairault, J., Emorine, L.J. J. Biol. Chem. (1994) [Pubmed]
  23. The role of beta-adrenergic receptor signaling in cardioprotection. Tong, H., Bernstein, D., Murphy, E., Steenbergen, C. FASEB J. (2005) [Pubmed]
  24. Serum and insulin induce a Grb2-dependent shift in agonist affinity of beta-adrenergic receptors. Shih, M., Malbon, C.C. Cell. Signal. (1998) [Pubmed]
  25. Protein kinase C potentiates isoproterenol-mediated cyclic AMP production without modifying the homologous desensitization process in J774 cells. Chambaut-Guerin, A.M., Thomopoulos, P. Eur. J. Biochem. (1987) [Pubmed]
  26. Targeted disruption of the beta 3-adrenergic receptor gene. Susulic, V.S., Frederich, R.C., Lawitts, J., Tozzo, E., Kahn, B.B., Harper, M.E., Himms-Hagen, J., Flier, J.S., Lowell, B.B. J. Biol. Chem. (1995) [Pubmed]
  27. B cell receptor- and beta 2-adrenergic receptor-induced regulation of B7-2 (CD86) expression in B cells. Kohm, A.P., Mozaffarian, A., Sanders, V.M. J. Immunol. (2002) [Pubmed]
  28. Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels. An, R., Heath, B.M., Higgins, J.P., Koch, W.J., Lefkowitz, R.J., Kass, R.S. J. Physiol. (Lond.) (1999) [Pubmed]
  29. Noncanonical cAMP pathway and p38 MAPK mediate beta2-adrenergic receptor-induced IL-6 production in neonatal mouse cardiac fibroblasts. Yin, F., Wang, Y.Y., Du, J.H., Li, C., Lu, Z.Z., Han, C., Zhang, Y.Y. J. Mol. Cell. Cardiol. (2006) [Pubmed]
  30. Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects. Rohrer, D.K., Desai, K.H., Jasper, J.R., Stevens, M.E., Regula, D.P., Barsh, G.S., Bernstein, D., Kobilka, B.K. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  31. Transcriptional down-regulation by insulin of the beta 3-adrenergic receptor expression in 3T3-F442A adipocytes: a mechanism for repressing the cAMP signaling pathway. Fève, B., Elhadri, K., Quignard-Boulangé, A., Pairault, J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  32. Distinct roles for Src tyrosine kinase in beta2-adrenergic receptor signaling to MAPK and in receptor internalization. Huang, J., Sun, Y., Huang, X.Y. J. Biol. Chem. (2004) [Pubmed]
  33. Beta 1-adrenergic regulation of the GT1 gonadotropin-releasing hormone (GnRH) neuronal cell lines: stimulation of GnRH release via receptors positively coupled to adenylate cyclase. Martínez de la Escalera, G., Choi, A.L., Weiner, R.I. Endocrinology (1992) [Pubmed]
  34. beta-Adrenergic receptor agonists increase apoptosis of adipose tissue in mice. Page, K.A., Hartzell, D.L., Li, C., Westby, A.L., Della-Fera, M.A., Azain, M.J., Pringle, T.D., Baile, C.A. Domest. Anim. Endocrinol. (2004) [Pubmed]
  35. Chromosomal organization of adrenergic receptor genes. Yang-Feng, T.L., Xue, F.Y., Zhong, W.W., Cotecchia, S., Frielle, T., Caron, M.G., Lefkowitz, R.J., Francke, U. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  36. Hair cycle-dependent changes in adrenergic skin innervation, and hair growth modulation by adrenergic drugs. Botchkarev, V.A., Peters, E.M., Botchkareva, N.V., Maurer, M., Paus, R. J. Invest. Dermatol. (1999) [Pubmed]
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