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Chemical Compound Review

MK-507     (2R,4R)-2-ethylamino-4- methyl-5,5-dioxo...

Synonyms: MK-0507, AC1Q3ETJ, LS-152562, MK 507, MK 0507, ...
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Disease relevance of dorzolamide


High impact information on dorzolamide


Biological context of dorzolamide


Anatomical context of dorzolamide


Associations of dorzolamide with other chemical compounds


Gene context of dorzolamide


Analytical, diagnostic and therapeutic context of dorzolamide


  1. Methazolamide 1% in cyclodextrin solution lowers IOP in human ocular hypertension. Gudmundsdóttir, E., Stefánsson, E., Bjarnadóttir, G., Sigurjónsdóttir, J.F., Gudmundsdóttir, G., Masson, M., Loftsson, T. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  2. Periorbital dermatitis as a side effect of topical dorzolamide. Delaney, Y.M., Salmon, J.F., Mossa, F., Gee, B., Beehne, K., Powell, S. The British journal of ophthalmology. (2002) [Pubmed]
  3. Dorzolamide hydrochloride and visual function in normal eyes. Sponsel, W.E., Harrison, J., Elliott, W.R., Trigo, Y., Kavanagh, J., Harris, A. Am. J. Ophthalmol. (1997) [Pubmed]
  4. Efficacy of dorzolamide hydrochloride in the management of chronic cystoid macular edema in patients with retinitis pigmentosa. Grover, S., Fishman, G.A., Fiscella, R.G., Adelman, A.E. Retina (Philadelphia, Pa.) (1997) [Pubmed]
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  11. Non-invasive assessment of ocular pharmacokinetics using Confocal Raman Spectroscopy. Bauer, N.J., Motamedi, M., Wicksted, J.P., March, W.F., Webers, C.A., Hendrikse, F. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (1999) [Pubmed]
  12. Effect of dorzolamide timolol combination versus timolol 0.5% on ocular bloodflow in patients with primary open-angle glaucoma. Harris, A., Jonescu-Cuypers, C.P., Kagemann, L., Nowacki, E.A., Garzozi, H., Cole, C., Martin, B. Am. J. Ophthalmol. (2001) [Pubmed]
  13. Assessment of retinal hemodynamics with the Canon laser blood flowmeter after a single dose of 2% dorzolamide hydrochloride eyedrops. Faingold, D., Hudson, C., Flanagan, J., Guan, K., Rawji, M., Buys, Y.M., Trope, G.E. Can. J. Ophthalmol. (2004) [Pubmed]
  14. Topical 2.0% dorzolamide vs oral acetazolamide for prevention of intraocular pressure rise after neodymium:YAG laser posterior capsulotomy. Ladas, I.D., Baltatzis, S., Panagiotidis, D., Zafirakis, P., Kokolakis, S.N., Theodossiadis, G.P. Arch. Ophthalmol. (1997) [Pubmed]
  15. Aqueous humor flow in normal human eyes treated with brimonidine and dorzolamide, alone and in combination. Tsukamoto, H., Larsson, L.I. Arch. Ophthalmol. (2004) [Pubmed]
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  17. The dorzolamide/timolol combination versus timolol plus pilocarpine: patient preference and impact on daily life. United States Patient Preference Study Group. International Patient Preference Study Group. Sverrisson, T., Gross, R., Pearson, J., Rusk, C., Adamsons, I. Journal of glaucoma. (1999) [Pubmed]
  18. Antiglaucoma eye drop pulses--increased interleukin-6 secretion by Tenon's capsule fibroblast cultures. Koh, S.W., Coll, T.J., Rose, L., Matsumoto, Y., Higginbotham, E.J. Journal of glaucoma. (2004) [Pubmed]
  19. Comparing the fixed combination dorzolamide-timolol (Cosopt) to concomitant administration of 2% dorzolamide (Trusopt) and 0.5% timolol -- a randomized controlled trial and a replacement study. Francis, B.A., Du, L.T., Berke, S., Ehrenhaus, M., Minckler, D.S. Journal of clinical pharmacy and therapeutics. (2004) [Pubmed]
  20. A randomized study of dorzolamide in the prevention of elevated intraocular pressure after anterior segment laser surgery. Dorzolamide Laser Study Group. Hartenbaum, D., Wilson, H., Maloney, S., Vacarelli, L., Orillac, R., Sharpe, E. Journal of glaucoma. (1999) [Pubmed]
  21. Voltammetric and HPLC determination of dorzolamide hydrochloride in eye drops. Erk, N. Die Pharmazie. (2003) [Pubmed]
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