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Chemical Compound Review

Peretinoin     (2E,4E,6E,10E)-3,7,11,15...

Synonyms: NIK-333, CCRIS 9040, NK-333, AC1O5OHU, LS-74863, ...
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Disease relevance of E 5166


High impact information on E 5166


Biological context of E 5166


Anatomical context of E 5166


Associations of E 5166 with other chemical compounds


Gene context of E 5166


Analytical, diagnostic and therapeutic context of E 5166


  1. Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group. Muto, Y., Moriwaki, H., Ninomiya, M., Adachi, S., Saito, A., Takasaki, K.T., Tanaka, T., Tsurumi, K., Okuno, M., Tomita, E., Nakamura, T., Kojima, T. N. Engl. J. Med. (1996) [Pubmed]
  2. Antitumor activity of vitamin A and its derivatives. Muto, Y., Moriwaki, H. J. Natl. Cancer Inst. (1984) [Pubmed]
  3. Morphological differentiation of human neuroblastoma cell lines by a new synthetic polyprenoic acid (E5166). Sugimoto, T., Sawada, T., Matsumura, T., Horii, Y., Kemshead, J.T., Suzuki, Y., Okada, M., Tagaya, O., Hino, T. Cancer Res. (1987) [Pubmed]
  4. A novel synthetic vitamin-A-like compound (a polyprenoic acid derivative: E-5166) inhibits UVB-stimulated epidermal ornithine decarboxylase activity. Nemoto, O., Koizumi, H., Aoyagi, T. Arch. Dermatol. Res. (1986) [Pubmed]
  5. Polyprenoic acid in hepatocellular carcinoma. Yang, C.H., Cheng, A.L. N. Engl. J. Med. (1996) [Pubmed]
  6. A novel synthetic vitamin A-like compound (a polyprenoic acid derivative, E-5166) inhibits the release of arachidonic acid stimulated by epidermal growth factor. Suya, H., Aoyagi, T., Koizumi, H., Fukaya, T., Nemoto, O. J. Invest. Dermatol. (1987) [Pubmed]
  7. Inhibitory effects of polyprenoic acid (E5166) on production and secretion of alpha-fetoprotein and on cell kinetics in human hepatoma cells. Sasaki, K., Kawasaki, S., Okita, K., Murakami, T., Takemoto, T., Takahashi, M. Jpn. J. Cancer Res. (1986) [Pubmed]
  8. Polyprenoic acid, E-5166, is effective in inhibiting the proliferation of keratinocytes in vitro. Koji, M., Kanzaki, T., Takashima, A. Arch. Dermatol. Res. (1990) [Pubmed]
  9. Effects of polyprenoic acid on thermal injury. Aida, T., Murata, J., Asano, G., Kanda, Y., Yoshino, Y. British journal of experimental pathology. (1987) [Pubmed]
  10. Inhibition of radiogenic and chemically induced transformation in C3H/10T-1/2 cells by a polyprenoic acid (E-5166). Borek, C., Ong, A., Muto, Y. Jpn. J. Cancer Res. (1986) [Pubmed]
  11. Effects of a synthetic polyprenoic acid (E-5166) on the gap junction of rat hepatocytes treated with liver tumor promoters, phenobarbital, and p,p'-dichlorodiphenyltrichloroethane. Sugie, S., Tanaka, T., Shima, H., Shinoda, T., Mori, H., Muto, Y. Toxicologic pathology. (1994) [Pubmed]
  12. In vitro binding affinity of novel synthetic polyprenoids (polyprenoic acids) to cellular retinoid-binding proteins. Muto, Y., Moriwaki, H., Omori, M. Gann = Gan. (1981) [Pubmed]
  13. Hepatocellular carcinoma: the high-risk patient. Nissen, N.N., Martin, P. J. Clin. Gastroenterol. (2002) [Pubmed]
  14. Inhibitory effects of chlorogenic acid, reserpine, polyprenoic acid (E-5166), or coffee on hepatocarcinogenesis in rats and hamsters. Tanaka, T., Nishikawa, A., Shima, H., Sugie, S., Shinoda, T., Yoshimi, N., Iwata, H., Mori, H. Basic Life Sci. (1990) [Pubmed]
  15. Chemoprevention of cancer--focusing on clinical trials. Kakizoe, T. Jpn. J. Clin. Oncol. (2003) [Pubmed]
  16. Novel systemic therapy options for hepatocellular carcinoma. Cusnir, M., Patt, Y.Z. Cancer journal (Sudbury, Mass.) (2004) [Pubmed]
  17. Inhibitory effects of synthetic acidic retinoid and polyprenoic acid on the development of hepatoma in rats induced by 3'-methyl-N, N-dimethyl-4-aminoazobenzene. Moriwaki, H., Muto, Y., Ninomiya, M., Kawai, K., Suzuki, Y., Seto, T. Gastroenterol. Jpn. (1988) [Pubmed]
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