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Chemical Compound Review

4-hydroxyproline     (2S)-4-hydroxypyrrolidine-2- carboxylic acid

Synonyms: SureCN21184, AG-K-68445, CHEBI:18240, HMDB06055, CTK5C9109, ...
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Disease relevance of cis-4-hydroxyproline


High impact information on cis-4-hydroxyproline


Chemical compound and disease context of cis-4-hydroxyproline


Biological context of cis-4-hydroxyproline

  • Stimulated OPCs exposed to the PH inhibitor cis-hydroxyproline (cis-HP), compared to the noninhibiting isomer trans-HP, for 11 days showed a dose-dependent decrease in cell proliferation, the surviving cells showed increased alkaline phosphatase activity [10].

Anatomical context of cis-4-hydroxyproline


Associations of cis-4-hydroxyproline with other chemical compounds


Gene context of cis-4-hydroxyproline


Analytical, diagnostic and therapeutic context of cis-4-hydroxyproline


  1. Sustained release of cis-hydroxyproline in the treatment of experimental proliferative vitreoretinopathy in rabbits. Yasukawa, T., Kimura, H., Tabata, Y., Miyamoto, H., Honda, Y., Ogura, Y. Graefes Arch. Clin. Exp. Ophthalmol. (2002) [Pubmed]
  2. Pharmacological therapy for proliferative vitreoretinopathy. Radtke, N.D., Weinsieder, A.D., Ballou, R.J. Graefes Arch. Clin. Exp. Ophthalmol. (1986) [Pubmed]
  3. Cis-hydroxyproline-induced inhibition of pancreatic cancer cell growth is mediated by endoplasmic reticulum stress. Mueller, C., Emmrich, J., Jaster, R., Braun, D., Liebe, S., Sparmann, G. World J. Gastroenterol. (2006) [Pubmed]
  4. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Riley, D.J., Kerr, J.S., Berg, R.A., Ianni, B.D., Pietra, G.G., Edelman, N.H., Prockop, D.J. Am. Rev. Respir. Dis. (1981) [Pubmed]
  5. Retention of nonhelical procollagen containing cis-hydroxyproline in rough endoplasmic reticulum. Uitto, J., Hoffman, H., Prockop, D.J. Science (1975) [Pubmed]
  6. Inhibition of collagen deposition in the extracellular matrix prevents the establishment of a stroma supportive of hematopoiesis in long-term murine bone marrow cultures. Zuckerman, K.S., Rhodes, R.K., Goodrum, D.D., Patel, V.R., Sparks, B., Wells, J., Wicha, M.S., Mayo, L.A. J. Clin. Invest. (1985) [Pubmed]
  7. Proline-mediated enhancement of hepatocyte function in a collagen gel sandwich culture configuration. Lee, J., Morgan, J.R., Tompkins, R.G., Yarmush, M.L. FASEB J. (1993) [Pubmed]
  8. Aortic endothelial cell migration. I. Matrix requirements and composition. Madri, J.A., Stenn, K.S. Am. J. Pathol. (1982) [Pubmed]
  9. Localization of procollagen I in the lysosome/endosome system of human fibroblasts. Ripley, C.R., Bienkowski, R.S. Exp. Cell Res. (1997) [Pubmed]
  10. Marrow stromal cell commitment to mineralization under the effect of a prolyl hydroxylase inhibitor. Klein, B.Y., Gal, I., Segal, D. J. Cell. Biochem. (1994) [Pubmed]
  11. cis-Hydroxyproline inhibits proliferation, collagen synthesis, attachment, and migration of cultured bovine retinal pigment epithelial cells. Yoo, J.S., Sakamoto, T., Spee, C., Kimura, H., Harris, M.S., Hinton, D.R., Kay, E.P., Ryan, S.J. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
  12. Acetylcholinesterase in cocultures of rat myotubes and spinal cord neurons: effects of collagenase and cis-hydroxyproline on molecular forms, intra- and extracellular distribution, and formation of patches at neuromuscular contacts. Vallette, F.M., De la Porte, S., Koenig, J., Massoulié, J., Vigny, M. J. Neurochem. (1990) [Pubmed]
  13. The effect of CIS hydroxyproline on ventral prostatic growth in rats. Uke, E., Lee, C., Grayhack, J.T. J. Urol. (1983) [Pubmed]
  14. Collagen synthesis inhibition reduces clustering of heparan sulfate proteoglycan and acetylcholine receptors but not agrin or p65, at neuromuscular contacts in vitro. Bixby, J.L. J. Neurobiol. (1995) [Pubmed]
  15. Isolation and characterization of vitamin-A-storing lung cells. Okabe, T., Yorifuji, H., Yamada, E., Takaku, F. Exp. Cell Res. (1984) [Pubmed]
  16. Collagen and the proliferation and differentiation of rat ventral prostate epithelial cells. Thornton, M., Frederickson, R., Mata, L., Mawhinney, M. Biol. Reprod. (1985) [Pubmed]
  17. Prolyl hydroxylase inhibitor and lysyl hydroxylase inhibitor inhibit spreading of corneal epithelium. Saika, S., Hashizume, N., Okada, Y., Kobata, S., Yamanaka, O., Uenoyama, K., Ooshima, A. Graefes Arch. Clin. Exp. Ophthalmol. (1994) [Pubmed]
  18. Nerve regeneration and pharmacological suppression of the scar reaction at the suture site. An experimental study on the effect of estrogen-progesterone, methylprednisolone-acetate and cis-hydroxyproline in rat sciatic nerve. Nachemson, A.K., Lundborg, G., Myrhage, R., Rank, F. Scandinavian journal of plastic and reconstructive surgery. (1985) [Pubmed]
  19. A method for obtaining and culturing large numbers of purified organ-derived murine endothelial cells. MacPhee, M.J., Wiltrout, R.H., McCormick, K.L., Sayers, T.J., Pilaro, A.M. J. Leukoc. Biol. (1994) [Pubmed]
  20. Analysis of cell-mediated mineralization in culture of bone-derived embryonic cells with neurofibromatosis. Klein, B.Y., Rojansky, N., Gal, I., Shlomai, Z., Liebergall, M., Ben-Bassat, H. J. Cell. Biochem. (1995) [Pubmed]
  21. Effect of proline analogs on oxygen toxicity-induced pulmonary fibrosis in the rat. Riley, D.J., Kerr, J.S., Yu, S.Y. Toxicol. Appl. Pharmacol. (1984) [Pubmed]
  22. Synthesis and characterization of magnetically responsive albumin microspheres containing cis-hydroxyproline for scar inhibition. Iannotti, J.P., Baradet, T.C., Tobin, M., Alavi, A., Staum, M. J. Orthop. Res. (1991) [Pubmed]
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