Chemical Compound Review:
CHEMBL320474 N-phenylhydroxylamine
Synonyms:
ACMC-1C7E0, CCRIS 5062, LS-310, NCI-C60093, AG-D-06124, ...
- Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions. Hein, D.W., Doll, M.A., Rustan, T.D., Ferguson, R.J. Cancer Res. (1995)
- Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus. Hein, D.W., Doll, M.A., Gray, K., Rustan, T.D., Ferguson, R.J. Cancer Res. (1993)
- Involvement of Cys69 residue in the catalytic mechanism of N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium. Sequence similarity at the amino acid level suggests a common catalytic mechanism of acetyltransferase for S. typhimurium and higher organisms. Watanabe, M., Sofuni, T., Nohmi, T. J. Biol. Chem. (1992)
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- Polymorphic expression of acetyl coenzyme A-dependent arylamine N-acetyltransferase and acetyl coenzyme A-dependent O-acetyltransferase-mediated activation of N-hydroxyarylamines by human bladder cytosol. Kirlin, W.G., Trinidad, A., Yerokun, T., Ogolla, F., Ferguson, R.J., Andrews, A.F., Brady, P.K., Hein, D.W. Cancer Res. (1989)
- Identification of free radicals produced in rat erythrocytes exposed to hemolytic concentrations of phenylhydroxylamine. Bradshaw, T.P., McMillan, D.C., Crouch, R.K., Jollow, D.J. Free Radic. Biol. Med. (1995)
- Aniline-, phenylhydroxylamine-, nitrosobenzene-, and nitrobenzene-induced hemoglobin thiyl free radical formation in vivo and in vitro. Maples, K.R., Eyer, P., Mason, R.P. Mol. Pharmacol. (1990)
- Purification and biochemical characterization of hepatic arylamine N-acetyltransferase from rapid and slow acetylator mice: identity with arylhydroxamic acid N,O-acyltransferase and N-hydroxyarylamine O-acetyltransferase. Mattano, S.S., Land, S., King, C.M., Weber, W.W. Mol. Pharmacol. (1989)
- Role of aniline metabolites in aniline-induced hemolytic anemia. Harrison, J.H., Jollow, D.J. J. Pharmacol. Exp. Ther. (1986)
- Bacterial conversion of hydroxylamino aromatic compounds by both lyase and mutase enzymes involves intramolecular transfer of hydroxyl groups. Nadeau, L.J., He, Z., Spain, J.C. Appl. Environ. Microbiol. (2003)
- Characterization of genes involved in the initial reactions of 4-chloronitrobenzene degradation in Pseudomonas putida ZWL73. Xiao, Y., Wu, J.F., Liu, H., Wang, S.J., Liu, S.J., Zhou, N.Y. Appl. Microbiol. Biotechnol. (2006)
- N-Hydroxyamide metabolites of lidocaine. Synthesis, characterization, quantitation, and mutagenic potential. Nelson, S.D., Nelson, W.L., Trager, W.F. J. Med. Chem. (1978)
- Phenylhydroxylamine: role in aniline-associated splenic oxidative stress and induction of subendocardial necrosis. Khan, M.F., Green, S.M., Ansari, G.A., Boor, P.J. Toxicol. Sci. (1998)
- A pharmacokinetic model to predict exposure of the bladder epithelium to urinary N-hydroxyarylamine carcinogens as a function of urine pH, voiding interval, and resorption. Young, J.F., Kadlubar, F.F. Drug Metab. Dispos. (1982)
- Acetylator genotype-dependent expression of arylamine N-acetyltransferase and N-hydroxyarylamine O-acetyltransferase in Syrian inbred hamster intestine and colon. Identity with the hepatic acetylation polymorphism. Ogolla, F., Ferguson, R.J., Kirlin, W.G., Trinidad, A., Andrews, A.F., Mpezo, M., Hein, D.W. Drug Metab. Dispos. (1990)
- Nitrobenzene carcinogenicity in animals and human hazard evaluation. Holder, J.W. Toxicology and industrial health. (1999)
- Formation and disposition of N-hydroxylated metabolites of aniline and nitrobenzene by isolated rat hepatocytes. Blaauboer, B.J., Van Holsteijn, C.W. Xenobiotica (1983)
- Participation of cytochrome P-450 in the reduction of nitro compounds by rat liver microsomes. Harada, N., Omura, T. J. Biochem. (1980)
- Oxidation-dependent inactivation of aryl sulfotransferase IV by primary N-hydroxy arylamines during in vitro assays. King, R.S., Duffel, M.W. Carcinogenesis (1997)
- Sensitive method for the detection of mutagenic nitroarenes and aromatic amines: new derivatives of Salmonella typhimurium tester strains possessing elevated O-acetyltransferase levels. Watanabe, M., Ishidate, M., Nohmi, T. Mutat. Res. (1990)
- Toxicokinetics and metabolism of aniline and 4-chloroaniline in medaka (Oryzias latipes). Bradbury, S.P., Dady, J.M., Fitzsimmons, P.N., Voit, M.M., Hammermeister, D.E., Erickson, R.J. Toxicol. Appl. Pharmacol. (1993)
- Cloning, sequencing, and recombinant expression of NAT1, NAT2, and NAT3 derived from the C3H/HeJ (rapid) and A/HeJ (slow) acetylator inbred mouse: functional characterization of the activation and deactivation of aromatic amine carcinogens. Fretland, A.J., Doll, M.A., Gray, K., Feng, Y., Hein, D.W. Toxicol. Appl. Pharmacol. (1997)
- Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases. Hein, D.W., Rustan, T.D., Ferguson, R.J., Doll, M.A., Gray, K. Arch. Toxicol. (1994)
- Biochemistry of cytosolic sulfotransferases involved in bioactivation. Falany, C.N., Wilborn, T.W. Adv. Pharmacol. (1994)
- Lack of evidence for metabolism of p-phenylenediamine by human hepatic cytochrome P450 enzymes. Stanley, L.A., Skare, J.A., Doyle, E., Powrie, R., D'Angelo, D., Elcombe, C.R. Toxicology (2005)
- Biotransformation of nitrosobenzene, phenylhydroxylamine, and aniline in the isolated perfused rat liver. Eyer, P., Kampffmeyer, H., Maister, H., Rösch-Oehme, E. Xenobiotica (1980)
- N-hydroxyarylamine O-acetyltransferase in hamster liver: identity with arylhydroxamic acid N,O-acetyltransferase and arylamine N-acetyltransferase. Saito, K., Shinohara, A., Kamataki, T., Kato, R. J. Biochem. (1986)