Chemical Compound Review:
DOTG 1,2-bis(2- methylphenyl)guanidine
Synonyms:
Nocceler DT, Sanceler DT, Soxinol DT, Vulkacite DOTG, Tocris-0841, ...
- Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice. Matsumoto, R.R., McCracken, K.A., Friedman, M.J., Pouw, B., De Costa, B.R., Bowen, W.D. Eur. J. Pharmacol. (2001)
- Protein phosphorylation and calcium uptake into rat forebrain synaptosomes: modulation by the sigma ligand, 1,3-ditolylguanidine. Brent, P.J., Herd, L., Saunders, H., Sim, A.T., Dunkley, P.R. J. Neurochem. (1997)
- Synthesis and in vitro evaluation of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: high-affinity ligands for the N,N'-di-o-tolylguanidine-labeled sigma binding site. Mewshaw, R.E., Sherrill, R.G., Mathew, R.M., Kaiser, C., Bailey, M.A., Karbon, E.W. J. Med. Chem. (1993)
- Interaction of sigma-compounds with receptor-stimulated phosphoinositide metabolism in the rat brain. Candura, S.M., Coccini, T., Manzo, L., Costa, L.G. J. Neurochem. (1990)
- Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogues, high-affinity ligands for the haloperidol-sensitive sigma receptor. Scherz, M.W., Fialeix, M., Fischer, J.B., Reddy, N.L., Server, A.C., Sonders, M.S., Tester, B.C., Weber, E., Wong, S.T., Keana, J.F. J. Med. Chem. (1990)
- Effects of subcutaneous and intracerebroventricular administration of the sigma receptor ligand 1,3-Di-o-tolylguanidine on body temperature in the rat: interactions with BMY 14802 and rimcazole. Bejanian, M., Pechnick, R.N., Bova, M.P., George, R. J. Pharmacol. Exp. Ther. (1991)
- Sigma receptor ligands modulate contractility, Ca++ influx and beating rate in cultured cardiac myocytes. Ela, C., Barg, J., Vogel, Z., Hasin, Y., Eilam, Y. J. Pharmacol. Exp. Ther. (1994)
- p-chlorophenylalanine-reversible reduction of sigma binding sites by chronic imipramine treatment in rat brain. Shirayama, Y., Nishikawa, T., Umino, A., Takahashi, K. Eur. J. Pharmacol. (1993)
- RU 3117 a steroidal compound with high affinity for sigma sites in rat testis membranes. Bonfils, A., Humbert, J., Philibert, D. J. Steroid Biochem. Mol. Biol. (1996)
- The sigma ligand 1,3-di-o-tolylguanidine depresses amino acid-induced excitation non-selectively in rat brain. Connick, J.H., Addae, J.I., Nicholson, C.D., Stone, T.W. Eur. J. Pharmacol. (1992)
- Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism. Matsumoto, R.R., Bowen, W.D., Tom, M.A., Vo, V.N., Truong, D.D., De Costa, B.R. Eur. J. Pharmacol. (1995)
- Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3-(1-adamantyl)guanidine, a ligand for sigma binding sites. Kimes, A.S., Wilson, A.A., Scheffel, U., Campbell, B.G., London, E.D. J. Med. Chem. (1992)
- Differential effects of repeated dl-pentazocine treatment on sigma binding sites in discrete brain areas of the rat. Shirayama, Y., Nishikawa, T., Takahashi, K. Neurosci. Lett. (1994)
- Phosphorylation of synapsin I and dynamin in rat forebrain synaptosomes: modulation by sigma (sigma) ligands. Brent, P.J., Haynes, H., Jarvie, P.E., Mudge, L., Sim, A.T., Dunkley, P.R. Neurosci. Lett. (1995)
- Evidence that the NH2-terminus of substance P modulates N-methyl-D-aspartate-induced activity by an action involving sigma receptors. Hornfeldt, C.S., Kitto, K.F., Larson, A.A. Eur. J. Pharmacol. (1996)
- Stimulation of rat striatal tyrosine hydroxylase activity following intranigral administration of sigma receptor ligands. Weiser, S.D., Patrick, S.L., Mascarella, S.W., Downing-Park, J., Bai, X., Carroll, F.I., Walker, J.M., Patrick, R.L. Eur. J. Pharmacol. (1995)
- Presynaptic imidazoline receptors. New developments in characterization and classification. Göthert, M., Brüss, M., Bönisch, H., Molderings, G.J. Ann. N. Y. Acad. Sci. (1999)
- Microinjection of sigma ligands into cranial nerve nuclei produces vacuous chewing in rats. Tran, T.T., de Costa, B.R., Matsumoto, R.R. Psychopharmacology (Berl.) (1998)
- Prenatal developmental toxicity study of the basic rubber accelerator, 1,3-di-o-tolylguanidine, in rats. Ema, M., Fujii, S., Matsumoto, M., Hirose, A., Kamata, E. Reprod. Toxicol. (2006)