Chemical Compound Review:
Rimcazol 9-[3-[(3S,5R)-3,5- dimethylpiperazin-1...
Synonyms:
Rimcazole, Rimcazolum, Tocris-1497, SureCN99084, CHEMBL275707, ...
- Effects of subcutaneous and intracerebroventricular administration of the sigma receptor ligand 1,3-Di-o-tolylguanidine on body temperature in the rat: interactions with BMY 14802 and rimcazole. Bejanian, M., Pechnick, R.N., Bova, M.P., George, R. J. Pharmacol. Exp. Ther. (1991)
- Sigma binding site ligands inhibit cell proliferation in mammary and colon carcinoma cell lines and melanoma cells in culture. Brent, P.J., Pang, G.T. Eur. J. Pharmacol. (1995)
- A role of sigma receptors on hypoxia/hypoglycemia-induced decrease in CA1 presynaptic fiber spikes in rat hippocampal slices. Shibata, S., Yamamoto, Y., Watanabe, S. Brain Res. (1995)
- Influence of 1,3-di-o-tolylguanidine and rimcazole, selective sigma ligands, on apomorphine and neuroleptic effects. Maj, J., Rogóz, Z., Skuza, G. Polish journal of pharmacology. (1993)
- Behavioral effects of rimcazole analogues alone and in combination with cocaine. Katz, J.L., Libby, T.A., Kopajtic, T., Husbands, S.M., Newman, A.H. Eur. J. Pharmacol. (2003)
- Rimcazole, a sigma receptor ligand, and the anticonvulsive action of conventional antiepileptic drugs. Borowicz, K.K., Wilczyński, P.M., Kleinrok, Z., Czuczwar, S.J. Journal of neural transmission (Vienna, Austria : 1996) (1998)
- A review of evidence for GABergic predominance/glutamatergic deficit as a common etiological factor in both schizophrenia and affective psychoses: more support for a continuum hypothesis of "functional" psychosis. Squires, R.F., Saederup, E. Neurochem. Res. (1991)
- Sigma receptor antagonists inhibit human lens cell growth and induce pigmentation. Wang, L., Prescott, A.R., Spruce, B.A., Sanderson, J., Duncan, G. Invest. Ophthalmol. Vis. Sci. (2005)
- Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents. Cao, J., Kulkarni, S.S., Husbands, S.M., Bowen, W.D., Williams, W., Kopajtic, T., Katz, J.L., George, C., Newman, A.H. J. Med. Chem. (2003)
- Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues. Husbands, S.M., Izenwasser, S., Kopajtic, T., Bowen, W.D., Vilner, B.J., Katz, J.L., Newman, A.H. J. Med. Chem. (1999)
- Regulation of sigma-receptors: high- and low-affinity agonist states, GTP shifts, and up-regulation by rimcazole and 1,3-Di(2-tolyl)guanidine. Beart, P.M., O'Shea, R.D., Manallack, D.T. J. Neurochem. (1989)
- Effects of sigma ligands on the nociceptin/orphanin FQ receptor co-expressed with the G-protein-activated K+ channel in Xenopus oocytes. Kobayashi, T., Ikeda, K., Togashi, S., Itoh, N., Kumanishi, T. Br. J. Pharmacol. (1997)
- Up-regulation of rat cortical sigma receptors after subchronic administration of rimcazole and 1,3-di(2-tolyl)guanidine. Manallack, D.T., Beart, P.M. Neuropharmacology (1988)
- The sigma [corrected] ligand rimcazole antagonises (+)SKF 10,047, but not (+)3-PPP, in the mouse isolated vas deferens. Kennedy, C., Jarvis, G.E., Henderson, G. Eur. J. Pharmacol. (1990)
- The sigma ligand rimcazole activates noradrenergic neurons projecting to the paraventricular nucleus and increases corticosterone secretion in rats. Eaton, M.J., Lookingland, K.J., Moore, K.E. Brain Res. (1996)
- The sigma receptor ligand rimcazole alters secretion of prolactin and alpha-melanocyte stimulating hormone by dopaminergic and non-dopaminergic mechanisms. Eaton, M.J., Lookingland, K.J., Moore, K.E. Eur. J. Pharmacol. (1996)
- Effect of D1- and D2-dopamine agonists on neocortical and hippocampal EEG activity of rat brain: modulation of rimcazole effect. Verma, A., Kulkarni, S.K., Nayar, U. Methods and findings in experimental and clinical pharmacology. (1993)
- Alterations in regional brain neurotensin concentrations produced by atypical antipsychotic drugs. Levant, B., Bissette, G., Widerlöv, E., Nemeroff, C.B. Regul. Pept. (1991)
- GBR-12909 and fluspirilene potently inhibited binding of [3H] (+)3-PPP to sigma receptors in rat brain. Contreras, P.C., Bremer, M.E., Rao, T.S. Life Sci. (1990)
- [3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter. Cao, J., Husbands, S.M., Kopajtic, T., Katz, J.L., Newman, A.H. Bioorg. Med. Chem. Lett. (2001)
- Phencyclidine (PCP) acts at sigma sites to induce c-fos gene expression. Sharp, J.W. Brain Res. (1997)
- Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain. Ferris, R.M., Tang, F.L., Chang, K.J., Russell, A. Life Sci. (1986)
- Effects of rimcazole, a specific antagonist of sigma sites, on the antitussive effects of non-narcotic antitussive drugs. Kamei, J., Iwamoto, Y., Misawa, M., Kasuya, Y. Eur. J. Pharmacol. (1993)
- Acute and subchronic effects of Rimcazole (BW 234U), a potential antipsychotic drug, on A9 and A10 dopamine neurons in the rat. Piontek, J.A., Wang, R.Y. Life Sci. (1986)
- Review of the pharmacological and clinical profile of rimcazole. Gilmore, D.L., Liu, Y., Matsumoto, R.R. CNS drug reviews. (2004)