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MeSH Review

Atrial Appendage

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Disease relevance of Atrial Appendage


Psychiatry related information on Atrial Appendage

  • During lateral and atrial appendage pacing, with a progressive decrease of AV interval to 160, 100, 80, 40, 0 msec, the ERP, the dispersion of ERP, functional refractory period (FRP), A2 and latency period (LP) did not change significantly, in both groups [6].

High impact information on Atrial Appendage

  • Acute ANP antagonism was produced by administration of the particulate guanylate cyclase coupled natriuretic peptide receptor antagonist, HS-142-1, to seven conscious dogs with ELVD and intact atrial appendages (ELVD-INTACT) [7].
  • Tissues from explanted recipient hearts and atrial appendage samples obtained during coronary bypass graft operations were also examined and displayed varying amounts of N-CAM immunoreactivity [8].
  • Cephalothin recipients who developed wound or blood stream infections had lower antibiotic levels in their atrial appendages than recipients not developing such infections (p = 0.02) [9].
  • METHODS AND RESULTS: Twenty-two halothane-anesthetized mongrel dogs underwent insertion of a transvenous lead at the right atrial appendage that was continuously paced at 400 beats per minute for 6 weeks [10].
  • METHODS AND RESULTS: Sections of atrial appendages (AUTHR, n = 14; controls (CO), n = 13) were analyzed for MC by Giemsa, toluidine blue, and berberine sulfate stains and by immunohistochemistry [11].

Chemical compound and disease context of Atrial Appendage


Biological context of Atrial Appendage

  • METHODS: Right atrial appendages were obtained from seven different groups of patients: nondiabetics, diet-controlled diabetics, noninsulin-dependent diabetics (NIDD) receiving KATP channel blockers, insulin-dependent diabetics (IDD), and patients with left ventricular ejection fraction (LVEF) >50%, LVEF between 30% and 50% and LVEF <30% [15].
  • Concentrations of fusidic acid, cloxacillin, and cefamandole in sera and atrial appendages of patients undergoing cardiac surgery [16].
  • The present studies were undertaken to gain insight into the intrarenal mechanisms participating in the post-UNX natriuresis in circumstances in which the release or the action of endogenous ANP were suppressed by prior removal of the right atrial appendage and by administration of monoclonal anti-ANP antibodies, respectively [17].
  • Distension of small balloons at the pulmonary vein-atrial junctions and in the left atrial appendage discretely to stimulate the atrial receptors in eleven dogs anaesthetized with chloralose resulted in a significant diuresis [18].

Anatomical context of Atrial Appendage


Associations of Atrial Appendage with chemical compounds

  • Right atrial appendage magnesium concentration correlated positively with serum creatinine concentration (r = 0.31, p = 0.002) and negatively with serum calcium concentration (r = -0.29, p = 0.013) [24].
  • OBJECTIVES: We compared the effects of intrapericardial and intracoronary nitroglycerin on coronary cross-sectional area as assessed by intravascular ultrasound and demonstrated the feasibility of local cardiac drug delivery by a newly developed method to access the normal pericardial space through the right atrial appendage [25].
  • Comparative penetration of cefonicid and cefazolin into the atrial appendage and pericardial fluid of patients undergoing open-heart surgery [26].
  • At 3 h the concentrations of ceforanide and cefamandole in atrial appendages were 28.0 and 5.0 micrograms/g, respectively [23].
  • Penetration of cephapirin and cephalothin into the right atrial appendage and pericardial fluid of patients undergoing open-heart surgery [27].

Gene context of Atrial Appendage


Analytical, diagnostic and therapeutic context of Atrial Appendage


  1. Comparative value of transthoracic and transesophageal echocardiography in the assessment of congenital abnormalities of the atrioventricular junction. Sreeram, N., Stümper, O.F., Kaulitz, R., Hess, J., Roelandt, J.R., Sutherland, G.R. J. Am. Coll. Cardiol. (1990) [Pubmed]
  2. Diazoxide provides protection to human myocardium in vitro that is concentration dependent. Deja, M.A., Golba, K.S., Kolowca, M., Widenka, K., Biernat, J., Wos, S. Ann. Thorac. Surg. (2004) [Pubmed]
  3. Anatomically corrected malposition of the great arteries. Lee, J.R., Kim, Y.J., Yun, Y.S., Rho, J.A., Suh, K.P. Ann. Thorac. Surg. (1991) [Pubmed]
  4. Incessant focal atrial tachycardia: a surgically remediable cause of cardiomyopathy. Giorgi, L.V., Hartzler, G.O., Hamaker, W.R. J. Thorac. Cardiovasc. Surg. (1984) [Pubmed]
  5. X-ray appearance and clinical significance of left atrial wall calcification. Shaw, D.R., Chen, J.T., Lester, R.G. Investigative radiology. (1976) [Pubmed]
  6. Effect of atrial pressure increase on effective refractory period and vulnerability to atrial fibrillation in patients with lone atrial fibrillation. Efremidis, M., Sideris, A., Prappa, E., Filippatos, G., Fillipatos, G., Athanasias, D., Kardara, D., Sioras, I., Kardaras, F. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. (1999) [Pubmed]
  7. A functional role for endogenous atrial natriuretic peptide in a canine model of early left ventricular dysfunction. Stevens, T.L., Burnett, J.C., Kinoshita, M., Matsuda, Y., Redfield, M.M. J. Clin. Invest. (1995) [Pubmed]
  8. Myocardial localization and isoforms of neural cell adhesion molecule (N-CAM) in the developing and transplanted human heart. Gordon, L., Wharton, J., Moore, S.E., Walsh, F.S., Moscoso, J.G., Penketh, R., Wallwork, J., Taylor, K.M., Yacoub, M.H., Polak, J.M. J. Clin. Invest. (1990) [Pubmed]
  9. Antibiotic prophylaxis for cardiovascular surgery. Efficacy with coronary artery bypass. Platt, R., Muñoz, A., Stella, J., VanDevanter, S., Koster, J.K. Ann. Intern. Med. (1984) [Pubmed]
  10. Chronic rapid atrial pacing. Structural, functional, and electrophysiological characteristics of a new model of sustained atrial fibrillation. Morillo, C.A., Klein, G.J., Jones, D.L., Guiraudon, C.M. Circulation (1995) [Pubmed]
  11. Increase and redistribution of cardiac mast cells in auricular thrombosis. Possible role of kit ligand. Bankl, H.C., Radaszkiewicz, T., Klappacher, G.W., Glogar, D., Sperr, W.R., Grossschmidt, K., Bankl, H., Lechner, K., Valent, P. Circulation (1995) [Pubmed]
  12. Effect of experimentally induced atrial fibrillation on coronary circulation in dogs. Wichmann, J., Ertl, G., Rudolph, G., Kochsiek, K. Basic Res. Cardiol. (1983) [Pubmed]
  13. Transcatheter occlusion of the left atrial appendage for stroke prevention. Bayard, Y.L., Ostermayer, S.H., Sievert, H. Expert review of cardiovascular therapy. (2005) [Pubmed]
  14. Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases. Dudley, S.C., Hoch, N.E., McCann, L.A., Honeycutt, C., Diamandopoulos, L., Fukai, T., Harrison, D.G., Dikalov, S.I., Langberg, J. Circulation (2005) [Pubmed]
  15. Failure to precondition pathological human myocardium. Ghosh, S., Standen, N.B., Galiñianes, M. J. Am. Coll. Cardiol. (2001) [Pubmed]
  16. Concentrations of fusidic acid, cloxacillin, and cefamandole in sera and atrial appendages of patients undergoing cardiac surgery. Bergeron, M.G., Desaulniers, D., Lessard, C., Lemieux, M., Després, J.P., Métras, J., Raymond, G., Brochu, G. Antimicrob. Agents Chemother. (1985) [Pubmed]
  17. Tubular site of the natriuresis after unilateral nephrectomy in the rat. Valentin, J.P., Ribstein, J., Mimran, A. Am. J. Med. Sci. (1993) [Pubmed]
  18. Diuresis from atrial receptors after hypophysectomy and local ablation with no changes in plasma vasopressin. Bennett, K.L., Linden, R.J. Quarterly journal of experimental physiology (Cambridge, England) (1988) [Pubmed]
  19. Intracardiac phased-array imaging: methods and initial clinical experience with high resolution, under blood visualization: initial experience with intracardiac phased-array ultrasound. Packer, D.L., Stevens, C.L., Curley, M.G., Bruce, C.J., Miller, F.A., Khandheria, B.K., Oh, J.K., Sinak, L.J., Seward, J.B. J. Am. Coll. Cardiol. (2002) [Pubmed]
  20. Receptor mediated presynaptic modulation of the release of noradrenaline in human papillary muscle. Matkó, I., Fehér, E., Vizi, E.S. Cardiovasc. Res. (1994) [Pubmed]
  21. Normal signal-void patterns in cardiac cine MR images. Mirowitz, S.A., Lee, J.K., Gutierrez, F.R., Brown, J.J., Eilenberg, S.S. Radiology. (1990) [Pubmed]
  22. Adenosine-induced release of cyclic adenosine 3',5'-monophosphate from the left ventricle in the anaesthetized intact dog. Huynh-Thu, T., Lammerant, J. J. Physiol. (Lond.) (1978) [Pubmed]
  23. Penetration of ceforanide and cefamandole into the right atrial appendage, pericardial fluid, sternum, and intercostal muscle of patients undergoing open heart surgery. Mullany, L.D., French, M.A., Nightingale, C.H., Low, H.B., Ellison, L.H., Quintiliani, R. Antimicrob. Agents Chemother. (1982) [Pubmed]
  24. Myocardial magnesium: relation to laboratory and clinical variables in patients undergoing cardiac surgery. Reinhart, R.A., Marx, J.J., Broste, S.K., Haas, R.G. J. Am. Coll. Cardiol. (1991) [Pubmed]
  25. Persistent primary coronary dilation induced by transatrial delivery of nitroglycerin into the pericardial space: a novel approach for local cardiac drug delivery. Waxman, S., Moreno, R., Rowe, K.A., Verrier, R.L. J. Am. Coll. Cardiol. (1999) [Pubmed]
  26. Comparative penetration of cefonicid and cefazolin into the atrial appendage and pericardial fluid of patients undergoing open-heart surgery. Dudley, M.N., Nightingale, C.H., Drezner, A.D., Low, H.B., Quintiliani, R. Antimicrob. Agents Chemother. (1984) [Pubmed]
  27. Penetration of cephapirin and cephalothin into the right atrial appendage and pericardial fluid of patients undergoing open-heart surgery. Quintiliani, R., Klimek, J., Nightingale, C.H. J. Infect. Dis. (1979) [Pubmed]
  28. Diabetes decreases mRNA levels of calcium-release channels in human atrial appendage. Guner, S., Arioglu, E., Tay, A., Tasdelen, A., Aslamaci, S., Bidasee, K.R., Dincer, U.D. Mol. Cell. Biochem. (2004) [Pubmed]
  29. Purification and sequence determination of bovine atrial natriuretic factor. Ong, H., McNicoll, N., Lazure, C., Seidah, N., Chrétien, M., Cantin, M., De Léan, A. Life Sci. (1986) [Pubmed]
  30. Short-term effects of rapid pacing on mRNA level of voltage-dependent K(+) channels in rat atrium: electrical remodeling in paroxysmal atrial tachycardia. Yamashita, T., Murakawa, Y., Hayami, N., Fukui, E., Kasaoka, Y., Inoue, M., Omata, M. Circulation (2000) [Pubmed]
  31. Gene expression of the natriuretic peptide system in atrial tissue of patients with paroxysmal and persistent atrial fibrillation. Tuinenburg, A.E., Brundel, B.J., Van Gelder, I.C., Henning, R.H., Van Den Berg, M.P., Driessen, C., Grandjean, J.G., Van Gilst, W.H., Crijns, H.J. J. Cardiovasc. Electrophysiol. (1999) [Pubmed]
  32. Is receptor cross-regulation in human heart caused by alterations in cardiac guanine nucleotide-binding proteins? Ferro, A., Plumpton, C., Brown, M.J. Clin. Sci. (1993) [Pubmed]
  33. Neural control of the endocrine rat heart. Jiao, J.H., Baertschi, A.J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  34. Isolated left superior vena cava to the left atrium with situs solitus and dextrocardia: extracardiac repair facilitated by juxtaposition of the atrial appendages. McElhinney, D.B., Mishaly, D.A., Moore, P., Brook, M.M., Reddy, V.M., Hanley, F.L. Am. J. Cardiol. (1997) [Pubmed]
  35. Attenuation of atrial natriuretic peptide response to sodium loading after cardiac operation. Amano, J., Suzuki, A., Sunamori, M., Shichiri, M., Marumo, F. J. Thorac. Cardiovasc. Surg. (1995) [Pubmed]
  36. Involvement of atrial natriuretic peptide in blood pressure reduction induced by estradiol in spontaneously hypertensive rats. Belo, N.O., Silva-Barra, J., Carnio, E.C., Antunes-Rodrigues, J., Gutkowska, J., Dos Reis, A.M. Regul. Pept. (2004) [Pubmed]
  37. Global and regional atrial function after rapid atrial pacing: an echo Doppler study. Hoit, B.D., Shao, Y., Gabel, M. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. (1997) [Pubmed]
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