Disease relevance of Crithmene

• OBJECTIVES: Thirty isolates of Pseudomonas aeruginosa, 15 isolates of Pseudomonas putida and 11 isolates of Pseudomonas fluorescens were tested for susceptibility to tea tree oil (TTO), the essential oil of Melaleuca alternifolia, and the components terpinen-4-ol, alpha-terpineol, cineole, gamma-terpinene and rho-cymene [1].
• It is necessary to prepare large amounts of gamma-terpinene synthase from Citrus unshiu (Satsuma mandarin) for the characterization, on this purpose we expressed the protein in Escherichia coli (E. coli) cells [2].

High impact information on Crithmene

• Results as well as the action of a newly discovered, very effective antioxidant (i.e., gamma-terpinene) are discussed [3].
• The kinetics of this reaction in cyclohexane and tert-butyl alcohol show that chain termination involves the formal HOO* + HOO* self-reaction over a wide range of gamma-terpinene, AIBN, and O(2) concentrations [4].
• In the present study the genotoxic potential of major compounds of thyme oil, i.e. thymol, carvacrol, and gamma-terpinene and of the methanolic extracts of thyme, were investigated in human lymphocytes by single-cell gel electrophoresis [5].
• No increase in DNA strand breakage was observed at thymol and gamma-terpinene concentrations below 0.1 mM, but at the higher concentration of 0.2 mM significant increases in DNA damage were seen [5].
• Purification and characterization of the monoterpene cyclase gamma-terpinene synthase from Thymus vulgaris [6].

Biological context of Crithmene

• Biotransformation of gamma-terpinene and (-)-alpha-phellandrene by the larvae of common cutworm (Spodoptera litura) [7].
• Plant gamma-terpinene synthase is a member of the monoterpene cyclase family, which produces a specific monoterpene through cyclization of geranyl diphosphate (GPP), but the monoterpene cyclases have not been fully characterized [2].
• Mechanism of inhibition of lipid peroxidation by gamma-terpinene, an unusual and potentially useful hydrocarbon antioxidant [8].
• We studied lipid metabolism to evaluate the effects of gamma-terpinene on suppression of increases in serum lipid concentrations using Triton WR1339-treated rats [9].

Associations of Crithmene with other chemical compounds

• Biosynthesis of aromatic monoterpenes: conversion of gamma-terpinene to p-cymene and thymol in Thymus vulgaris L [10].
• The pediculicidal activities of (-)-alpha-pinene, 2-beta-pinene, and (E)-pinocarveol were comparable to those of delta-phenothrin and pyrethrum. l-Phellandrene, gamma-terpinene, and 1-alpha-terpineol were relatively less active than delta-phenothrin and pyrethrum. beta-Eudesmol and geranyl acetate were ineffective [11].
• The main components of C. cyminum oil were p-mentha-1,4-dien-7-al, cumin aldehyde, gamma-terpinene, and beta-pinene, while those of the C. carvi oil were carvone, limonene, germacrene D, and trans-dihydrocarvone [12].
• Their antioxidant activities decreased in the following order in both assays: alpha-terpinene > alpha-terpinolene > gamma-terpinene [13].

Analytical, diagnostic and therapeutic context of Crithmene

• Gas chromatography and GC/mass spectrometry studies of its essential oil showed its major components to be carvacrol and its biosynthetic precursors (gamma-terpinene and P-cymene) [14].
• The monoterpene cyclase, gamma-terpinene synthase, from Thymus vulgaris (thyme) leaves was purified to apparent homogeneity by isoelectric focusing and dye-ligand, anion-exchange, hydrophobic interaction, and gel permeation chromatography [6].

References