Disease relevance of nonane

• Petroleum hydrocarbon toxicity studies XVII. Animal response to n-nonane vapor [1].
• The TEWL and erythema data indicate that irritation was in the following order: tetradecane > dodecane > nonane [2].

High impact information on nonane

• The delta tolC mutant accumulated n-nonane or decane (log P(OW) = 6. 0) more abundantly than the parent or the delta acrAB mutant [3].
• The degenerate electron exchange (DEE) reaction involving radical cations (RCs) of n-nonane, n-dodecane, and n-hexadecane in n-hexane solution was studied over the temperature range 253-313 K using the method of time-resolved magnetic field effect in recombination fluorescence of spin-correlated radical ion pairs [4].
• The effects of aliphatic (n-nonane), naphtenic (1,2, 4-trimethylcyclohexane), and aromatic (1,2,4-trimethylbenzene) hydrocarbons on respiratory burst in human neutrophil granulocytes [5].
• Also, alkanes such as n-octane, 2,2, 4-trimethylpentane corresponding to tert-octane, and n-nonane exhibited no binding [6].
• The metabolism of nonane, a JP-8 jet fuel component, by human liver microsomes, P450 isoforms and alcohol dehydrogenase and inhibition of human P450 isoforms by JP-8 [7].

Chemical compound and disease context of nonane

• Biochemical studies on the toxicity of n-octane and n-nonane [8].

Biological context of nonane

• n-Octane and n-nonane induced alterations in xenobiotic metabolising enzyme activities and lipid peroxidation of rat liver [9].
• Synthetic mixtures of three C9 n-paraffinic, naphthenic and aromatic hydrocarbons (n-nonane, trimethylcyclohexane and trimethylbenzene, respectively) were studied in the rat after inhalation for 12h [10].
• JP-8 spiked with 5.0 microCi of radiolabeled (14C) tridecane, nonane, naphthalene or toluene (selected components of JP-8) was used for the in vitro percutaneous absorption studies with excised pig ear skin and human skin [11].
• On the high nonane activity side the theoretical nucleation rates are about three orders of magnitude lower than the experimental data when using the CNT with the approximate kinetics [12].
• Among 23 kinds of organic solvents added, hydrophobic alkanes promoted esterification, especially isooctane, n-nonane, and n-hexane [13].

Anatomical context of nonane

• For n-nonane, no significant decreases in the EC50 values were observed over time; marginal cytotoxicity of n-nonane in keratinocytes was observed at 1h [14].

Associations of nonane with other chemical compounds

• The retention of chemicals in stratum corneum (SC) was in the order of tetradecane > dodecane > nonane, and directly correlated to the log Kp (r2 = 0.9900) and molecular weight of the chemicals (r2 = 0.8782) [2].
• Skin of the Brazilian toad Melanophryniscus moreirae (family Bufonidae) contains a new alkaloid 8-hydroxy-8-methyl-6-(5'-hydroxy-2'-methyl-hexylidene)-1-azabicycl o-[4.3.0] nonane (C16H29NO2), which is designated pumiliotoxin 267C [15].
• High pressure liquid chromatography (HPLC) permitted the detection of the dicarboxylic acids malonic acid and glutaric acid in the n-nonane dosed rat urines [16].

Gene context of nonane

• Likewise, nonane significantly increased the expression of IL-1alpha, TNF-alpha and MCP-1 in skin and blood as compared to control at different time points [17].
• The release of cytokines by nonane exposure was further supported by activation of NFkappaB p65 and corresponding degradation of IkappaBalpha in the skin [17].
• The delta tolC mutant was more sensitive to nonane than the delta acrAB mutant [3].
• The response of evidential breath alcohol testing instruments with subjects exposed to organic solvents and gases. II. White spirit and nonane [18].

Analytical, diagnostic and therapeutic context of nonane

• 5. Analysis of the metabolites extracted from the microsomal incubations by gas chromatography/mass spectroscopy indicated that the parent isomers had been hydroxylated in the C-8 position on the nonane chain to give 2-(4-hydroxyphenyl)-8-hydroxynonane, 3-(4-hydroxyphenyl)-8-hydroxynonane and 4-(4-hydroxyphenyl)-8-hydroxynonane [19].

References