Disease relevance of decane

• Atiprimod (2-(3-Diethylaminopropyl)-8,8-dipropyl-2-azaspiro[4,5] decane dimaleate) has exerted anti-inflammatory activities and inhibited oeteoclast-induced bone resorption in animal models and been well tolerated in patients with rheumatoid arthritis in phase I clinical trials [1].
• Chromatophores of photosynthetic bacteria Rhodospirillum rubrum, Rhodopseudomonas sphaeroides and Chromatium minutissimum were associated with a collodion film impregnated with a decane solution of asolectin [2].
• METHODS AND RESULTS: Resting cells of Streptomyces clavuligerus strain NP1 were incubated with penicillin G, required co-factors and decane in the presence of catalase or superoxide dismutase, and production of DAOG was measured [3].
• The derived amino acid sequence of the alkB-amplificate of Pseudomonas aureofaciens showed high homology (95%) with AlkB from Ps. oleovorans. alkB gene disruptants were not able to grow with decane [4].

High impact information on decane

• It was previously shown (Cohen, F. S., J. Zimmerberg, and A. Finkelstein, 1980, J. Gen. Physiol., 75:251-270) that multilamellar phospholipid vesicles can fuse with decane-containing phospholipid bilayer membranes [5].
• Furthermore, membranes formed using the solvent decane (instead of squalane) are completely insensitive to the presence of oligomers [6].
• The LTGC SPME macrofibers were used to extract five lung cancer-related VOCs (2-methylheptane, styrene, propylbenzene, decane, undecane) at conditions simulating human breath, and they were analyzed via gas chromatography/mass spectrometry [7].
• In GMO/decane (thick) bilayers, the largest flicker frequency occurred in the SS channel (39 s(-1)), followed by the RR (4 s(-1)) and native gA channels (3 s(-1)) [8].
• The specific capacitance of membranes formed from decane-containing monogalactosyldiacylglycerol (MGDG), which accounts for 57% of the total lipid content of thylakoids, showed that it adopted a bilayer structure [9].

Biological context of decane

• Blocking kinetics were evaluated from steady-state, single-channel recordings from rat skeletal muscle sodium channels incorporated into planar, neutral phospholipid/decane bilayers (200 mM NaCl, 10 mM HEPES-NaOH, pH 7.0) [10].
• Introduction of YlALK1 on a plasmid to the disruptant restored the decane assimilation [11].
• An aqueous formulation and a water in oil emulsion of a lipophilic salt, a decane sulfonic acid derivative of [D-Leu6-desGly10]LH-RH ethylamide gave ID bioavailabilities of approximately 0.2% and 1%, respectively [12].
• The hydrolysis of poly(ortho-ester)s and a monomeric model compound, 3,9-dibenzyloxy-3,9-diethyl-2,4,8,10-tetraoxaspiro[5,5]un decane, was carried out in dioxane-d8-dioxane and followed by 1H-NMR and HPLC, respectively [13].
• The partial inhibition of growth on decane is probably due to the denaturation of the microsomal electron carrier systems by the fatty acid formed by hydroxylation of the decane in the yeast [14].

Anatomical context of decane

• 6-Methylquinoline was also degraded in a nonaqueous solution by this strain of P. putida when a solution of 6-methylquinoline in decane was flowed through an immobilized-cell fixed-bed bioreactor [15].
• Time-course samples for 1200 ppm and end-of-exposure samples for 781 and 273 ppm decane exposures were collected from blood, brain, liver, fat, bone marrow, lung, skin, and spleen [16].
• The solventless bilayers are characterized by a large specific capacitance (586-957 nF/cm2) comparable to that of cell membranes but considerably greater than that of conventional lipid/decane bilayers [17].

Associations of decane with other chemical compounds

• We demonstrate that the particle mediated interaction between a pendant water drop, covered by a latex particle monolayer, and a planar decane/water interface leads to bridging, analogous to flocculation in solid-stabilised emulsions [18].
• These findings were confirmed by direct measurement of the partition of radiolabeled halothane into the membranes and by direct determination of the partition parameter of 5-doxyl decane by electron paramagnetic resonance spectroscopy [19].
• Membranes were formed from diphytanoyl phosphatidylcholine in decane plus chlorodecane (50% vol/vol) [20].
• For nonane and decane, the ratio of the partial pressure required for anesthesia to the saturated vapor pressure was less than 1, being 0.48 and 0.19, respectively [21].
• 1) Reflectivity of "black" regions of films made of TP in decane and hexadecane decreases by several percent with a time constant (tauR) of about 30 min, whereas that of membranes with hexane and heptane does not depend on time (with an accuracy up to 1--2%) [22].

Gene context of decane

• Increasing the concentration of decane sulfonate in an aqueous bFGF solution decreased the rate and extent of GnHCl-induced denaturation and demonstrated no inherent capacity to significantly alter the conformation of bFGF by itself [23].
• Correction of PHA for those temperature effects considered to be independent of lipid chain order (i.e., enthalpy of transfer from water to decane and activation energy for diffusion in bulk hydrocarbon) yielded an improved correlation (kappa = -11.7 +/- 0.5 (r = 0.96)) [24].
• Critical phenomenon of nonaqueous microemulsion (AOT/DMA/decane) [25].
• The partition of cytochrome c between an aqueous phase in equilibrium with a microemulsion composed of sodium dodecylbenzenesulfonate, butanol, and decane was studied [26].
• In contrast, the Y. lipolytica UGT51 gene is required for utilization of decane, but not for pexophagy [27].

Analytical, diagnostic and therapeutic context of decane

• Distribution of decane within the unit cell of the inverted hexagonal (HII) phase of lipid-water-decane systems determined by neutron diffraction [28].
• Fluorescence titrations show binding of the decane derivative to two sites on the protein whereas the lower homologs bind largely to one site [29].
• Enhanced digital video microscopy is applied to study the equilibrium structure of a two-dimensional charged sulfate-polystyrene particle (2 mum in diameter) monolayer at decane/water interfaces [30].
• N.m.r. studies clearly establish immobilization of both ends of the molecule on binding in the case of the decane derivative, whereas in the lower homologs the dimethylamino group on the naphthalene ring is significantly more affected in the presence of enzyme [29].

References